Sentences with phrase «functional genomic approaches»

Using the oral microbial community as a model system, we are applying functional genomic approaches including Stable Isotope Probing (SIP), metatrascriptomics and directed single cell genomic approaches to enable us to overcome this limitation.

PHENOMIN - CIPHE develops functional genomic approaches to create preclinical models of the immune system.

The work is the first time that a large - scale functional genomic approach has been used to systematically examine how bacteria can gain capabilities that improve their ability to colonize living organisms, in this case mice.

To accomplish this, I take a functional genomics approach to identify novel genes important for testes development and function.

Identification of new pathological biomarkers for monogenic diseases using a functional genomic approach.

The Parasite Genomics group uses comparative and functional genomics approaches to investigate the biology of helminths and protozoan parasites.

Since ants are not afforded the molecular and genetic tools of traditional model organisms, we will begin addressing the question of colony queen number with a functional genomics approach.

Not exact matches

The advances in genotyping and functional genomics open new approaches to environmental science, including public health issues

With the advent of the genomic era, however, biological investigators are confronted daily with ever ‐ growing data sets that contain potentially useful functional information which can not readily be analyzed optimally with the conventional approach.

-- In silico basic and systems biology: We develop innovative approaches to reverse engineer biological networks from omics data, model tumor progression at the genomic, transcriptomic and epigenetic level, automatically annotate new proteins and functional elements through integration of complex and heterogeneous data, including data obtained from high - throughput sequencing or time - lapse video - microscopy.

Large - scale functional genomics data often fail to connect to standard experimental approaches of gene characterization in individual laboratories.

Ageing research and more generally the study of the functional basis of human diseases profit enormously from the large - scale approaches and resources in mouse functional genomics: systematic targeted mutation of the mouse genome, systemic phenotyping in mouse clinics, and the archiving and distribution of the mouse resources in public repositories.

Cellecta Inc., a functional genomics solutions provider, focuses primarily on developing and implementing flexible and scalable broad - based screening and analysis approaches for drug target and biomarker discovery.

The Functional Genomic and Computational Assessment of Threats (Fun GCAT) program challenges research teams to develop new approaches for screening genetic information for evidence of a potential biological threat.

The goal of our conference is to disseminate recent findings emerging from cell biology, biochemistry, biophysics, functional - genomics, systems and computational approaches; and integrate them into a mechanistic understanding of the global principles of cell division.

His research focuses on the use of genomic approaches to uncover the functional impact of human genetic variation, and especially its role in causing severe Mendelian diseases.

This section invites manuscripts describing (a) Linkage, association, substitution or positional mapping and epigenetic studies in any species; (b) Validation studies of candidate genes using genetically - engineered mutant model organisms; (c) Studies focused on epistatis and gene - environment interactions; (d) Analysis of the functional implications of genomic sequence variation and aim to attach physiological or pharmacogenomic relevance to alterations in genes or proteins; (e) Studies of DNA copy number variants, non-coding RNA, genome deletions, insertions, duplications and other single nucleotide polymorphisms and their relevance to physiology or pharmacology in humans or model organisms, in vitro or in vivo; and (f) Theoretical approaches to analysis of sequence variation.

By combining the fission yeast, mouse, and human systems with the latest genomic, genetic, cell biological, and biochemical approaches, we seek to determine how condensin and cohesin organize the functional 3D genome structures and participate in various biological processes, including transcriptional regulation and chromosomal dynamics, and how they contribute to oncogenic processes.

As part of an ongoing functional genomic screening approach, we have been using microarray analysis and next generation sequencing to identify mouse genes that are specifically expressed in meiosis, and are likely involved in aspects of chromosome biology that are required for meiotic ploidy reduction.

We apply personalised functional genomics to study diseases in patient - derived cells using systematic and targeted approaches to unravel mechanisms and discover novel treatments (see video).