Sentences with phrase «functional homologs»

The researchers conclude that Upd2 is the «functional homolog» of leptin, meaning the protein in flies acts very much like leptin does in people.

Using microelectrodes, the researchers recorded the electrical activity of pheromone - sensitive interneurons in male American cockroaches that relay signals of female - producing sex pheromones in the antennal lobe (functional homolog to the mammalian olfactory bulb) to higher - order centers.

Not exact matches

We identified human X-linked genes whose gametologs have been pseudogenized or completely lost from the Y chromosome and inferred which evolutionary forces may be acting to retain genes on the Y. Although gene loss appears to be largely correlated with the suppression of recombination, we observe that X-linked genes with functional Y homologs evolve under stronger purifying selection and are expressed at higher levels than X-linked genes with nonfunctional Y homologs.

Additionally, we support and expand upon the hypothesis that X inactivation is primarily driven by gene loss on the Y. Using linear discriminant analysis, we show that X-inactivation status can successfully classify 90 % of X-linked genes into those with functional or nonfunctional Y homologs.

Functional annotations from Ensembl BioMart, TAIR10, Phytozome, and MaizeGDB were based on homologs determined through Ensembl Compara gene trees (gramene.org).

The presence of a Boule homolog (+), testis expression or functional requirement (T) or ovary expression or functional requirement (O) is marked.

To understand the functional evolution of bilaterian Boule, we surveyed the expression of Boule homologs in representative bilaterian species and determined the functional conservation of deuterostomian Boule through expression and genetic analyses of the mouse Boule homolog.

We identified homologs of Boule in the major phyla of metazoans, reconstructed the evolutionary history of Boule, and began to determine its functional divergence.

Furthermore, a human BOULE transgene rescued partial testicular defects of fly boule mutants, suggesting functional similarity between these two distant homologs [44].

While meiosis is fundamental to sexual reproduction and key components of meiotic machinery for chromosomal synapses and recombination are conserved from yeast to mammals [2], [76], the absence of Boule homologs in fungi together with the requirement of Boule homologs in only one sex of animals suggest that conservation of Boule is unlikely due to the same functional constraint that keeps components of meiotic machinery conserved.

We've shown the widespread presence of Boule homologs throughout bilaterian animals and the functional conservation of a reproductive - exclusive requirement among Drosophila, worm and mouse.

Phylogenetic and genomewide analyses suggest a functional relationship between kayak, the Drosophila fos homolog, and fig, a predicted protein phosphatase 2c nested within a kayak intron.