Researchers funded by the National Institute of Biomedical Imaging and Bioengineering at Tufts University and their collaborators have successfully developed a 3 - dimensional (3D) tissue - engineered model of bone marrow that can produce
functional human platelets outside the body (ex vivo).
David Kaplan, Ph.D., professor and Director of the NIH P41 Resource Center on Tissue Engineering, Alessandra Balduini, M.D., and their collaborators have focused on forming bone marrow models with these components and other growth factors to imitate and support the formation of
functional human platelets.
A team led by researchers at the Tufts University School of Engineering and the University of Pavia has reported development of the first three - dimensional tissue system that reproduces the complex structure and physiology of human bone marrow and successfully generates
functional human platelets.
Top, the bioreactor that can make fully
functional human platelets.
Not exact matches
To address these limitations, investigators from Japan developed a strategy to derive
functional platelets from
human induced pluripotent stem cells.
Platelets generated from
human embryonic stem cells are
functional in vitro and in the microcirculation of living mice.