Sentences with phrase «functional role of this protein»

In the future, studies are aimed at using novel molecular approaches to selectively delete AMPK in specific brain regions associated with nicotine dependence to better understand the functional role of this protein in addiction.

My research attempts to integrate these methods in order to investigate important questions in evolution: reconstructing ancestral protein sequences and determining the functional roles of proteins existing in organisms early in the history of life.

Not exact matches

Second, Südhof pioneered the use of genetically modified mice to examine the functional role of these skey proteins and the machinery that regulates the calcium mechanism of neurotransmitter release.

Quantitative analyses of multiple cardiac phenotypes demonstrated essential structural, functional and developmental roles for these genes, including a subgroup encoding histone H3K4 modifying proteins.

Südhof then made use of the emerging power of mouse genetics to delineate the functional role of a number of these vesicle proteins including the role of synaptotagmin, which he demonstrated to be the critical calcium sensor for rapid neurotransmitter release.

Symposia X: The Impact of Heat Shock Protein Expression on Muscle Metabolism, Exercise Capacity and Disease Prevention Speakers will present evidence for the functional effects and mechanisms of heat shock proteins and their role in aging, mitochondrial function, apoptotic pathways, insulin sensitivity, myocardial protection and more.

In this study, the presence of tau protein in cardiac tissue is confirmed and the functional role in the cardiovascular system and the consequences of its loss were explored.

This study supports a functional role of tau in the heart and loss of this protein leads to a deterioration in cardiovascular performance which worsens with age.

To examine the functional role of Smad1 and Smad5 in GDF5 - induced neurite length, primary cultures were transfected by microporation with siRNAs targeting the co-Smad4 (required for nuclear translocation of Smad1 / 5 transcriptional complex [33]-RRB- or the Smad1 and Smad5 effectors proteins, which are known targets of miR - 181a (Table 2).

The proteins displayed on the merozoite cell surface have long been considered attractive vaccine targets because of their direct exposure to host antibodies; however, progress in understanding the functional role of these targets has been hindered by technical challenges associated with expressing these proteins in a functionally active recombinant form.

These studies demonstrate that the two important protein complexes, condensin and cohesin, are both essential for the assembly of the functional genome architecture, but their roles in the 3D genome organization (gene contacts and topological domain organization) are significantly different.

«The functional role of leucine in regulating [TOR] activity» may help explain the extraordinary results reported in the Cornell - Oxford - China Study, since «[q] uasi - vegan diets of modest protein content tend to be relatively low in leucine.»