Sentences with phrase «functioning hematopoietic»
«Proper blood cell production is dependent on functioning hematopoietic stem and progenitor cells that are destroyed during conditioning procedures for transplantation or following bone marrow injury,» said the study's first author Kevin A. Goncalves, who performed this research as part of his PhD studies in cellular and molecular physiology at the Sackler School.
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Hematopoietic stem cells, that form mature blood cells, require a very precise amount of protein to function — and defective regulation of protein production is common in certain types of aggressive human blood cancers.
«Transplanted hematopoietic stem cells reverse damage caused by neuro - muscular disorder: In mouse model of Friedreich's ataxia, a single infusion measurably restored normal cellular functions.»
Stowers researchers discovered that megakaryocytes directly regulate the function of murine hematopoietic stem cells — adult stem cells that form blood and immune cells and that constantly renew the body's blood supply.
In the context of the current study, TRAF6's regulation of RNA isoform expression is important to the function of hematopoietic cells and reveals another dimension to how cells respond to infection, Starczynkowski said.
Since then he has continued to investigate new strategies to overcome the major hurdles to safe and effective gene transfer, translate then into new therapeutic strategies for genetic disease and cancer, and allowed new insights into hematopoietic stem cell function, induction of immunological tolerance and tumor angiogenesis.
Hepatocyte growth factor ameliorates acute graft - versus - host disease and promotes hematopoietic function.
Coordinated and unique functions of the E-selectin ligand ESL - 1 during inflammatory and hematopoietic recruitment in mice.
Furthermore, these potentials are expanded by the notion that MSCs can exert functions other than those classically attributed to stem or progenitor cells, including establishment and support of the hematopoietic microenvironment in vivo, as observed for bone marrow derived MSCs.
c - myc in the hematopoietic lineage is crucial for its angiogenic function in the mouse embryo.
Under normal physiological conditions, CXCR4 is mainly expressed in the hematopoietic and immune systems (Figure 1), where it carries out multiple functions.
Tie2 expression and function has been established in hematopoietic stem cells13, macrophages14, muscle satellite cells15, neural cells16 and tumour cells17, 18.
Title: Hematopoietic Stem Cell Function and Survival Depend on c - Myc and N - Myc Activity Authors: Laurenti E, Varnum - Finney B, Wilson A, Ferrero I, Blanco - Bose WE, Ehninger A, Knoepfler PS, Cheng PF, MacDonald HR, Eisenman RN, Bernstein ID, Trumpp A Date: 2008 Publication Details: Cell Stem Cell, Volume 3, Issue 6, 611 - 624, 4 December 2008
Modulating ECM assembly to alter tumor vascular barrier function Weilan Ye, Genentech Lymphangiogenesis and lymphatic endothelial barrier as targets in regenerative medicine Giorgia Jurisic, Novartis Wnt / beta - catenin signaling as a therapeutic target for blood - brain barrier repair in neurological disorders Dritan Agalliu, Columbia University Somatic mutations in hematopoietic cells contribute to cardiovascular disease: New mechanisms, new targets Kenneth Walsh, Boston University
In response, St. Jude researchers have re-engineered a lentivirus to function as a vector to ferry a normal copy of IL2RG into the patients» hematopoietic stem cells.
Telomere dysfunction induces environmental alterations limiting hematopoietic stem cell function and engraftment.
Telomere dysfunction induces environmental defects limiting hematopoietic stem cell function and engraftment.
Aging of the hematopoietic stem cell (HSC) compartment is characterized by lineage bias and reduced stem cell function, the molecular basis of which is largely unknown.
It is a cofactor in several oxidative enzymes vital to the function of hematopoietic, vascular and skeletal tissues, as well as the structure and function of the nervous system, including superoxide dismutase (oxygen radical scavenger), cytochrome - c oxidase (mitochondrial respiration), lysyl oxidase (collagen and elastin synthesis) and ceruloplasmin ferroxidase / haephestin (iron metabolism).
Furthermore, there is evidence suggesting an association of replication stress on rDNA loci with the aging of hematopoietic stem cells, adding more evidence to the general function of the nucleolus in genome integrity and aging.