Sentences with phrase «functioning of other genes»

This can disrupt the functioning of other genes and create novel proteins that have never been in the food supply and could create toxins and allergens in foods.

Ongoing studies comparing the function of other genes during branchial ray and fin / limb development will help to resolve this.

«Instead of looking solely at the genes directly implicated in autism through their genetic code changes, we really should be also studying the functions of the other genes implicated by these changes in genetic code through epigenetic connections.»

Not exact matches

Essentially the model reproduces the inner workings of all of the proteins within the organism and allows scientists to see everything from how cells interact with each other to the functions of genes in a larger context that had not been previously understood.

Furthermore, despite the claim that evolution has no application, phylogenetic comparisons of humans and other organisms allows us to identify the precise location and putative function of genes responsible for developmental disorders.

In other words, they now have total control over that genome and can examine the function of every gene, seeing if each part of the genome serves a biological function or is redundant.

Lots of Taste Buds + Bitter Gene = Supertaster People who maintain more taste buds and have a high - functioning TAS2R38 gene can be much more sensitive to tastes than othGene = Supertaster People who maintain more taste buds and have a high - functioning TAS2R38 gene can be much more sensitive to tastes than othgene can be much more sensitive to tastes than others.

It has been estimated that 5 % to 10 % of infants who die from SIDS have novel mutations in the cardiac sodium or potassium channel genes that result in long QT syndrome as well as in other genes that regulate channel function.44 A recent report described important new molecular and functional evidence that implicates specific SCN5A (sodium channel gene) β subunits in SIDS pathogenesis.47 The identification of polymorphisms in genes pertinent to the embryologic origin of the autonomic nervous system in SIDS cases also lends support to the hypothesis that a genetic predisposition contributes to the etiology of SIDS.

What are the biological functions of the other expressed genes?

In the new research, the UB scientists found they could reverse those social deficits with a very low dose of romidepsin, which, they found, restores gene expression and function using an epigenetic mechanism, where gene changes are caused by influences other than DNA sequences.

In these and other inherited diseases, 10 to 15 percent of the single - base pair mutations that cause the disease create a misplaced, premature «stop» codon in the middle of the gene — causing the machinery of the cell to prematurely halt synthesis of the protein, which destroys its ability to function.

Studies have shown that more than 50 % of all human cancers carry defects in the p53 gene, and almost all other cancers with a normal p53 function carry other defects which indirectly impair the cancer - fighting function of p53.

Astoundingly, Venter says that his team could not identify the function of 149 of the genes in syn3.0's genome, many of which are found in other life forms, including humans.

But Voigt and others note that this complete definition remains a ways off, because the function of 149 of Syn 3.0's genes — roughly one - third — remains unknown.

Another doubled - up region contains enhancers that turn on some genes in the cerebellum, a part of the brain that coordinates movement, speech and performs other important functions.

Others want to deliver working copies of broken genes into retinal cells, restoring their function.

They also found other sets of genes that were not originally important for diversification of form and function, that later became important in reducing the viability of hybrids.

These genes are believed to be essential for the normal function of nerve cells, and previous studies have linked these mutations to problems with synaptic function — how neurons communicate with each other.

Specifically, Toni Gabaldón's group at the Centre for Genomic Regulation in Barcelona has compared the Iberian lynx genome with those of other species, attempting to identify genes that have lost their function because they have remained isolated and the existence of a small population of specimens of this species.

Over the longer term, the identification of the coffee tree genome sequence opens up new possibilities for varietal improvement, knowledge of the specific functions of the genes (in particular those specific to coffee trees), the possibility of transferring results to other species, and refining diagnostic tools for the function of the plant.

The three Ras genes found in humans — H - Ras, K - Ras and N - Ras — were among the first to be linked to cancer development, and a new study led by VCU Massey Cancer Center researcher Paul Dent, Ph.D., has shown the recently approved breast cancer drug neratinib can block the function of Ras as well as several other oncogenes through an unexpected process.

If we knew what those functions were, then maybe we'd have a better way of manipulating these cells, so I'd be keen on performing some experiments to explore what these other genes do.

We know that Hox genes encode transcription factors that control the activity of other genes, but we found that digit - innervating motor neurons also express other genes, such as FIGN and CNEP4], and we still don't know the function of any of these other genes.

What we were surprised to find out was that the real differences we could detect in terms of when we did the swap experiments to say which yeast could outperform the other — what we learned was that the GAL1 gene, that the part [of] that, the DNA sequence is outside of the GAL1 gene, it acts as a switch to turn up or turn down GAL1 expression, that had evolved considerably from the ancestral situation; and same for the GAL3.And then what had happened was that each function had been optimized, that GAL3 had sort have been tuned to be sort of a loosely regulated kind of available anytime sensor of galactose and GAL1 had evolved to be an incredibly tightly regulated, in fact, it's the most tightly regulated gene you know of in yeast.

Some duplicated genes were lost over time but others took on new functions, including contributions to the development of floral organs.

Importantly, the small remnants of the messenger RNA can then function like additional microRNAs, binding to other copies of the messenger RNA, causing further gene silencing.

«We thought that what we were seeing was the rapid specialization of genes as venoms, and loss of their other function.»

The protein, called XBP - 1s, turns on genes that direct the assembly of other proteins that keep insulin function working correctly in the cells.

The site's core pages give an overview of fly development, and others list detailed information about the locations of genes in chromosomes, the structure and function of the proteins they encode, and references to the scientific literature.

They did, however, find copies of genes related to CDR1, CDR2, and few others that encode other transporters associated with drug resistance — although the way they function in C. krusei is unknown.

(Because of the strong sequence similarities between the two genes, the scientists have not yet been able to turn off one without the other, so differences between their functions are still unclear.)

According to the report on the effort, which was published in the December 11 issue of Science, analysis of the worm's genome revealed 19,099 protein - coding genes — about one every 5,000 DNA bases — and 800 or so genes that have other functions.

The alteration is predicted to result in the production of a shortened ETV6 protein that can not fulfill its normal function of binding to DNA and regulating the expression of other genes.

Some of the pinpointed genes are known to be involved in the function of synapses, tiny connectors that allow brain cells to communicate with each other through electrical and chemical signals.

Bioinformatic approaches to the analysis of genetic variability and complex genotype - phenotype relationships will moreover include gene sequence and database analyses, measures of association of haplotypes / genotypes with phenotype, clustering procedures, neuronal networks, fuzzy and other techniques in pattern recognition, similarity measures for discrete patterns (e.g., gene sequences, structures, functions), logistic regression methods, and a spectrum of other techniques.

«We are hopeful that a systemic dose and delivery of gene therapy would broadly affect whole - body strength and function, and we are working on a host of projects for such systemic delivery in Pompe and other neuromuscular conditions,» said Barry Byrne, M.D., Ph.D., director of the Powell Gene Therapy Center, a professor of pediatrics in the UF College of Medicine, and a member of the UF Genetics Institgene therapy would broadly affect whole - body strength and function, and we are working on a host of projects for such systemic delivery in Pompe and other neuromuscular conditions,» said Barry Byrne, M.D., Ph.D., director of the Powell Gene Therapy Center, a professor of pediatrics in the UF College of Medicine, and a member of the UF Genetics InstitGene Therapy Center, a professor of pediatrics in the UF College of Medicine, and a member of the UF Genetics Institute.

Loss of the PBRM1 gene function caused the cancer cells to have increased expression of other genes, including gene pathway known as IL6 / JAK - STAT 3, which are involved in immune system stimulation.

Cebrià highlights that «as there are genes which are similar to egr - 4 in other lineages — for instance the human species — , this function may be particularly interesting to understand the process of regeneration in metazoans.»

The genes had broad functions including controlling the expression of genes in many other areas of the genome.

Other labs will pitch in for the final assembly and annotation of the genome, as well as analyzing the functions of the new genes discovered.

The regulation of the CAMP gene by vitamin D was discovered by Gombart, and researchers are still learning more about how it and other compounds affect immune function.

But what our studies suggest is that there is a whole new universe where you can now screen for other functions, like the ability to block conjugation or to induce the loss of resistance genes.

Based on studies of other genes related to FOXP2, the authors suggest that the loss of functioning protein from one copy of this gene might disrupt the proper growth of key speech and language structures in the brain.

A strong link has been established between adequate vitamin D levels and the function of the CAMP gene, and the new research suggests that certain other compounds may play a role as well.

The team also found that these genes had different functions in promoting metastasis: One group encouraged growth of tumor cells in both breast and lungs, whereas the other only helped the new tumor thrive in the lungs.

«Regarding the other histones, which are major proteins in the regulation of gene expression, we know which enzymes modify them, their functions, and how they are regulated... But for some reason, the functions of histone 1 have not been addressed,» he adds.

Gene analyses of the hippocampus and other brain areas revealed dysregulation in the genes linked to manifestation of damaging reactive oxygen species and neuronal function.

«The collaboration of scientists with computational skills, others with population genetics and large - scale genomics knowledge, and those with in - depth understanding of gene function and interaction from the molecular to the whole - tree level is a major step forward,» she said.

The group hopes to examine the effect in clinical trials in the future, and plans to look at the function of the other six genes their study identified.

Furthermore, if transcriptional regulation of adipose tissue function contributes to adiposity - dependent modulation of insulin sensitivity, blood pressure, and other medically important traits, then the genes that correlate with body mass will be candidates for mediating these responses and warrant further evaluation.