Sentences with phrase «functions as a transcription factor»

They later showed that RORA, a nuclear hormone receptor that functions as a transcription factor, can potentially regulate the transcription of more than 2,500 genes, including over 400 genes already associated with autism.

Here, we have shown for the first time that the unphosphorylated STAT2 could play an important role in RIG - G gene expression by interacting with IRF - 9, further reinforcing the idea that STAT proteins could function as transcription factors in the absence of tyrosine phosphorylation.

Not exact matches

In all the pathways so far investigated, the final result is a gradient of morphogen that functions principally as a transcription factor, initiating or suppressing the transcription of one or more target genes in a concentration - dependent manner.

We know that Hox genes encode transcription factors that control the activity of other genes, but we found that digit - innervating motor neurons also express other genes, such as FIGN and CNEP4], and we still don't know the function of any of these other genes.

The new consortium proposes to characterize and tag the 1486 known transcription factors — proteins that switch genes on and off — in the mouse genome, as well as an estimated 600 coregulators that chip in to control cellular and biological functions through networks called regulons.

In addition, when these transcription factors lose their function, terminal differentiation into the vascular endothelium (completion of differentiation) is completely suppressed, and genes that are key to differentiation into vascular endothelial cells as well as transcription factors that maintain the undifferentiated state are adversely induced.

Previously, in the region that controls the function of the transcription factor that promotes differentiation from ES cells to a specific cell type, bivalent modifications of histones such as the accelerator and brake histone marks for transcription were thought to have coexisted.

Over the past decade, we have also demonstrated that the zinc finger transcription factor KLF15 functions as a nodal regulator of cardiovascular plasticity and multi-organ metabolic homeostasis.

Defined the transcription factor KLF15 as a nodal regulator of cardiovascular function and multi-organ metabolic homeostasis

Nucleocytoplasmic Shuttling of a GATA Transcription Factor Functions as a Development Timer.

Activated ERK1 / 2 modulates the functions of several transcription factors, protein kinases, protein phosphatases, cytoskeletal proteins, signaling molecules, apoptosis - related proteins, as well as other types of proteins [32], while activated AKT modulates the function of numerous substrates involved in the regulation of cell survival, cell cycle progression and cellular growth [33, 34], whereas JNK acts as pro-apoptotic as well as anti-apoptotic depending on the conditions [35].

They may exert a transcriptional function or act as comodulators for other transcription factors.

The transcription factors usually function as homodimers or heterodimers to regulate the gene expression in eukaryotic cells and their activities are dependent on distinct protein - protein interaction.

In the case of STAT6, we speculate that p300 may function as a result of its HAT activity and / or by bridging active interaction between STAT6 and general transcription factors.

These four proteins are well known EMT transcription factors that function as decisive early drivers of EMT.

As mentioned in the beginning of this section, the «longevity gene» FoxO3a functions as a suppressor of PCSK9 gene expression when the FoxO3a transcription factor can enter the cell nucleuAs mentioned in the beginning of this section, the «longevity gene» FoxO3a functions as a suppressor of PCSK9 gene expression when the FoxO3a transcription factor can enter the cell nucleuas a suppressor of PCSK9 gene expression when the FoxO3a transcription factor can enter the cell nucleus.