Sentences with phrase «further changes to both teams»

The second half started with no further changes to both teams and it looked like Arsenal was the team to score with Chamberlain making move after move going forward but it was the finishing touch that was lacking for our team.

Not exact matches

«The opportunity to have our team work alongside top design talent and entrepreneurs in a collaborative environment will further our leadership in developing the innovations that will change the way Canadians bank.»

Rahn... Do i really need to back up what i think online... and you being the expert... why do nt you fully explain to me the state that the country is in... enlighten me... but you already know how far that will go... just as my attempt to change others mind's fell short... so will any others opinion... i have my mind made up for my own well founded reasons... all im saying is that spending all day protesting and postulating is of no benefit to anyone... going about your life and making things best for yourself is in the best interest of this country as a whole... I believe Adam Smith said it best... the best results come from one person doing whats best for himself and the team... not throwing a hissy fit

Actually David I am convinced the deal WILL go through and was always optimistic we would get Auba as soon as it was reported we would be trying to sign him.Why?Because I believe Ivan G is implementing the changes at the club that is the beginning of removing the absolute power Wenger has enjoyed at the club for far too long.From what I understand the negotiating team have been in Dortmund all week (and they haven't been kicking a ball around or putting fairy liquid in the fountains I've seen all 4 times I've visited the City).

If low variance Alex Smith has played below expectations (possibly far below) twice against this PIT team and still came so damn close to winning the game both times, then you know your best chance at winning comes with Alex Smith and minor changes that put him in a better position to meet expectations and / or convert just one of those missed chances.

The big team news as far as United are concerned is that Wayne Rooney returns to the starting line - up and reclaims the captain's armband in the absence of Ibrahimovic with Anthony Martial alongside him, while Daley Blind comes in at the back to replace Rojo as Mourinho makes eight changes in total from midweek.

You guys should stop call Wenger Mr.. He ain't deserved to be call mister because a mister will always stick to his word and never allowed to be disrespected by his followers but not Wenger so his far from being a master not from the past 10 to 11 years when we the fans always being a laughing stock from other club fans We tired of being mistreated all the time from Wenger we need changes we need a coach or a manager that can make arsenal fc a better team a team that every fans will love to support, a team that will be best among the rest.

I'm so sick of people telling those of us who are disgruntled fans to relax and give this club time to correct itself... for anyone who believes that taking a wait - and - see approach is appropriate at this juncture they should take a good long look at themselves in the mirror because they are a big part of the problem... no other «big» club's fans would stand for this shit for nearly as long as we have... think about it, we've witnessed a changing of the guard at every major club in England, Spain, France and Germany in the last several years because those «big» clubs failed to live up to expectations (Barcelona, Real Madrid, Bayern, PSG, Chelsea, ManU, ManCity etc...)... for some reason, many fans have become as fragile as our current manager, believing that there couldn't possibly be a suitable replacement, even though everyone of these clubs have found multiple replacements and still achieved far more than our club... this mindset has been created by an organization that has been milking it's fans, telling countless lies (no world class players available) and lowering expectations every since they rolled out the biggest lie of all: that we couldn't spend because of the new stadium but once it was paid off we could compete with any team in the world... this organization is rotting from the inside out and if we don't demand that those in charge put soccer first this despicable behaviour won't end with Wenger's ridiculous 2 year contract... I think the real fear isn't that a suitable replacement doesn't exist, but that this organization is so money hungry and poorly mismanaged that we will sink even lower by choosing our next coach the same way they choose our players, on the cheap... even so, we need to see what mustache will do if left to his own devices so he will have to show his true colours... only then can we purge this club and start anew

And please don't say ex AFC players because as far as I can tell none of them are barely started out as of yet (would be a long punt) Simone, would have to change not only the entire team, but also the coaching / coaches set up, also tear down the youth system and bring in a huge amount of new kids because they are AFC type hopefuls not AM types.

This is an incredibly difficult question to answer for a variety of reasons, most importantly because over the years our once vaunted «beautiful» style of play has become a shadow of it's former self, only to be replaced by a less than stellar «plug and play» mentality where players play out of position and adjustments / substitutions are rarely forthcoming before the 75th minute... if you look at our current players, very few would make sense in the traditional Wengerian system... at present, we don't have the personnel to move the ball quickly from deep - lying position, efficient one touch midfielders that can make the necessary through balls or the disciplined and pacey forwards to stretch defences into wide positions, without the aid of the backs coming up into the final 3rd, so that we can attack the defensive lanes in the same clinical fashion we did years ago... on this current squad, we have only 1 central defender on staf, Mustafi, who seems to have any prowess in the offensive zone or who can even pass two zones through so that we can advance play quickly out of our own end (I have seen some inklings that suggest Holding might have some offensive qualities but too early to tell)... unfortunately Mustafi has a tendency to get himself in trouble when he gets overly aggressive on the ball... from our backs out wide, we've seen pace from the likes of Bellerin and Gibbs and the spirited albeit offensively stunted play of Monreal, but none of these players possess the skill - set required in the offensive zone for the new Wenger scheme which requires deft touches, timely runs to the baseline and consistent crossing, especially when Giroud was playing and his ratio of scored goals per clear chances was relatively low (better last year though)... obviously I like Bellerin's future prospects, as you can't teach pace, but I do worry that he regressed last season, which was obvious to Wenger because there was no way he would have used Ox as the right side wing - back so often knowing that Barcelona could come calling in the off - season, if he thought otherwise... as for our midfielders, not a single one, minus the more confident Xhaka I watched played for the Swiss national team a couple years ago, who truly makes sense under the traditional Wenger model... Ramsey holds onto the ball too long, gives the ball away cheaply far too often and abandons his defensive responsibilities on a regular basis (doesn't score enough recently to justify): that being said, I've always thought he does possess a little something special, unfortunately he thinks so too... Xhaka is a little too slow to ever boss the midfield and he tends to telegraph his one true strength, his long ball play: although I must admit he did get a bit better during some points in the latter part of last season... it always made me wonder why whenever he played with Coq Wenger always seemed to play Francis in a more advanced role on the pitch... as for Coq, he is way too reckless at the wrong times and has exhibited little offensive prowess yet finds himself in and around the box far too often... let's face it Wenger was ready to throw him in the trash heap when injuries forced him to use Francis and then he had the nerve to act like this was all part of a bigger Wenger constructed plan... he like Ramsey, Xhaka and Elneny don't offer the skills necessary to satisfy the quick transitory nature of our old offensive scheme or the stout defensive mindset needed to protect the defensive zone so that our offensive players can remain aggressive in the final third... on the front end, we have Ozil, a player of immense skill but stunted by his physical demeanor that tends to offend, the fact that he's been played out of position far too many times since arriving and that the players in front of him, minus Sanchez, make little to no sense considering what he has to offer (especially Giroud); just think about the quick counter-attack offence in Real or the space and protection he receives in the German National team's midfield, where teams couldn't afford to focus too heavily on one individual... this player was a passing «specialist» long before he arrived in North London, so only an arrogant or ignorant individual would try to reinvent the wheel and / or not surround such a talent with the necessary components... in regards to Ox, Walcott and Welbeck, although they all possess serious talents I see them in large part as headless chickens who are on the injury table too much, lack the necessary first - touch and / or lack the finishing flair to warrant their inclusion in a regular starting eleven; I would say that, of the 3, Ox showed the most upside once we went to a back 3, but even he became a bit too consumed by his pending contract talks before the season ended and that concerned me a bit... if I had to choose one of those 3 players to stay on it would be Ox due to his potential as a plausible alternative to Bellerin in that wing - back position should we continue to use that formation... in Sanchez, we get one of the most committed skill players we've seen on this squad for some years but that could all change soon, if it hasn't already of course... strangely enough, even he doesn't make sense given the constructs of the original Wenger offensive model because he holds onto the ball too long and he will give the ball up a little too often in the offensive zone... a fact that is largely forgotten due to his infectious energy and the fact that the numbers he has achieved seem to justify the means... finally, and in many ways most crucially, Giroud, there is nothing about this team or the offensive system that Wenger has traditionally employed that would even suggest such a player would make sense as a starter... too slow, too inefficient and way too easily dispossessed... once again, I think he has some special skills and, at times, has showed some world - class qualities but he's lack of mobility is an albatross around the necks of our offence... so when you ask who would be our best starting 11, I don't have a clue because of the 5 or 6 players that truly deserve a place in this side, 1 just arrived, 3 aren't under contract beyond 2018 and the other was just sold to Juve... man, this is theraputic because following this team is like an addiction to heroin without the benefits

also don't expect much changes in d team other den those 2 holding midfielders, i hope arteta is fit and starts, and wilshere gets a chance to impress further.

you have to give it to WENGER when he is one step away from being sacked (wishful thinking), the team responds by winning few games and other teams inexplicably lose, perfect formula to keep our beloved 4th place and give WENGER something to brag about... btw WENGER so far so good see some changes... Sanogo on loan darn he is finally listening,

It is a puzzling one, podolski is by - far not the most popular but by an arm length the most lethal given the opportunities, it sound's like wenger feels he's defensive attitude Is not right but arsenal are only good when they work as a team (defensively), I just think wenger Doesn't know how to play him with out changing the way arsenal play

It's been nice to read a page that so far people are able to have different views and has yet to have a load of hysterical AKB's trying to deny that changes are badly needed and telling everybody to support another team if they want to see changes.

Louis van Gaal has inherited a difficult enough job as it is after making the move to the club in the summer, and so far the team may be suffering from so many changes happening so quickly, with a great change in playing staff since the difficult blow of Sir Alex Ferguson's retirement.

Secondly, Wenger needs to become far more flexible when it comes to his formation selections... remember this is the same individual that hadn't used a 3 - back system for 20 years and only conceded to the experiment when the proverbial shit hit the fan... you know it killed him to adopt «Conte's» system, which is probably why he resisted so long; in fact his stubbornness to adjust even earlier might have cost us the 4 hole... much like most sports that have tactical formations, every team should have a «base» offensive and defensive scheme, but they likewise need to have some inherent flexibility depending on the opposing teams tactics and / or when specific substitutions are made... how many times have you watched a Wenger - run team make a late substitution but not change their shape on the pitch... furthermore, how many times have you seen our team fail to make the necessary adjustments at halftime due to Wenger's tactical stubbronness, which often led to giving up goals in the early minutes of the second - half... the best teams in the world know how to make halftime adjustments whereas we always seem to be surprised when the opposing team throws a wrinkle into the mix following halftime... this my friend is soccer 101

It has been made perfectly clear that he wants to playing Champions League football this season, and with a team worthy of winning it, but our club have so far rejected any offers for his signature, but may be set to change their minds.

Time for some brutal honesty... this team, as it stands, is in no better position to compete next season than they were 12 months ago, minus the fact that some fans have been easily snowed by the acquisition of Lacazette, the free transfer LB and the release of Sanogo... if you look at the facts carefully you will see a team that still has far more questions than answers... to better show what I mean by this statement I will briefly discuss the current state of affairs on a position - by - position basis... in goal we have 4 potential candidates, but in reality we have only 1 option with any real future and somehow he's the only one we have actively tried to get rid of for years because he and his father were a little too involved on social media and he got caught smoking (funny how people still defend Wiltshire under the same and far worse circumstances)... you would think we would want to keep any goaltender that Juventus had interest in, as they seem to have a pretty good history when it comes to that position... as far as the defenders on our current roster there are only a few individuals whom have the skill and / or youth worthy of our time and / or investment, as such we should get rid of anyone who doesn't meet those simple requirements, which means we should get rid of DeBouchy, Gibbs, Gabriel, Mertz and loan out Chambers to see if last seasons foray with Middlesborough was an anomaly or a prediction of things to come... some fans have lamented wildly about the return of Mertz to the starting lineup due to his FA Cup performance but these sort of pie in the sky meanderings are indicative of what's wrong with this club and it's wishy - washy fan - base... in addition to these moves the club should aggressively pursue the acquisition of dominant and mobile CB to stabilize an all too fragile defensive group that has self - destructed on numerous occasions over the past 5 seasons... moving forward and building on our need to re-establish our once dominant presence throughout the middle of the park we need to target a CDM then do whatever it takes to get that player into the fold without any of the usual nickel and diming we have become famous for (this kind of ruthless haggling has cost us numerous special players and certainly can't help make the player in question feel good about the way their future potential employer feels about them)... in order for us to become dominant again we need to be strong up the middle again from Goalkeeper to CB to DM to ACM to striker, like we did in our most glorious years before and during Wenger's reign... with this in mind, if we want Ozil to be that dominant attacking midfielder we can't keep leaving him exposed to constant ridicule about his lack of defensive prowess and provide him with the proper players in the final third... he was never a good defensive player in Real or with the German National squad and they certainly didn't suffer as a result of his presence on the pitch... as for the rest of the midfield the blame falls squarely in the hands of Wenger and Gazidis, the fact that Ramsey, Ox, Sanchez and even Ozil were allowed to regularly start when none of the aforementioned had more than a year left under contract is criminal for a club of this size and financial might... the fact that we could find money for Walcott and Xhaka, who weren't even guaranteed starters, means that our whole business model needs a complete overhaul... for me it's time to get rid of some serious deadweight, even if it means selling them below what you believe their market value is just to simply right this ship and change the stagnant culture that currently exists... this means saying goodbye to Wiltshire, Elneny, Carzola, Walcott and Ramsey... everyone, minus Elneny, have spent just as much time on the training table as on the field of play, which would be manageable if they weren't so inconsistent from a performance standpoint (excluding Carzola, who is like the recent version of Rosicky — too bad, both will be deeply missed)... in their places we need to bring in some proven performers with no history of injuries... up front, although I do like the possibilities that a player like Lacazette presents, the fact that we had to wait so many years to acquire some true quality at the striker position falls once again squarely at the feet of Wenger... this issue highlights the ultimate scam being perpetrated by this club since the arrival of Kroenke: pretend your a small market club when it comes to making purchases but milk your fans like a big market club when it comes to ticket prices and merchandising... I believe the reason why Wenger hasn't pursued someone of Henry's quality, minus a fairly inexpensive RVP, was that he knew that they would demand players of a similar ilk to be brought on board and that wasn't possible when the business model was that of a «selling» club... does it really make sense that we could only make a cheeky bid for Suarez, or that we couldn't get Higuain over the line when he was being offered up for half the price he eventually went to Juve for, or that we've only paid any interest to strikers who were clearly not going to press their current teams to let them go to Arsenal like Benzema or Cavani... just part of the facade that finally came crashing down when Sanchez finally called their bluff... the fact remains that no one wants to win more than Sanchez, including Wenger, and although I don't agree with everything that he has done off the field, I would much rather have Alexis front and center than a manager who has clearly bought into the Kroenke model in large part due to the fact that his enormous ego suggests that only he could accomplish great things without breaking the bank... unfortunately that isn't possible anymore as the game has changed quite dramatically in the last 15 years, which has left a largely complacent and complicit Wenger on the outside looking in... so don't blame those players who demanded more and were left wanting... don't blame those fans who have tried desperately to raise awareness for several years when cracks began to appear... place the blame at the feet of those who were well aware all along of the potential pitfalls of just such a plan but continued to follow it even when it was no longer a financial necessity, like it ever really was...

With players like Sam Darnold, Josh Rosen, Josh Allen, and Baker Mayfield all prepped to be high first - round picks, it means a game - changing defender like Chubb could slide all the way to the No. 6 pick — where a Colts team with a potentially healthy Andrew Luck awaits — or farther.

I agree with those odds simply because i believe the some team that were stronger than Arsenal last season have done some really good business to further strengthen there squads, Bernardo Silva & Kyle Walker for Man City with what they already have plus what pep will add plus its gonna be his second season so he will be a bit more familiar with the EPL and this may make them really tough to beat, Tiemoue Bakayoko & Antonio Rudiger Chealsea plus a top striker and Chelsea will sill be one of the teams to beat, Tottenham are gonna be solid, they've kept the team together and Victor Lindelof & Romelu Lukaku for Man - u and Mourinho is not done yet if the rumors are true and there also the Mourinho second season thing, as much as i'd like to be hopeful for next season, i really do nt think Lacazette and Kolasinac are enough to make us challenge for the league plus having Europa league will give the team less time to recover for the weekend games, the formation change is the only thing i see can make the difference.

This House of Cards created by the thin - skinned narcissist and our absentee landlord is going to come crashing down over the next 12 months and anyone who doesn't put the success of the club ahead of blind allegiances will need to check themselves so that we can move forward once the dust has settled... this club has been on auto - pilot for far too long and the same old, same old just won't cut it in the new EPL where many of the best managers, players and deepest pockets in the world now reside... just think to yourself what has transpired in the last 7 years alone: Leicester City won the EPL, Chelsea and ManCity have changed several managers and still won the League on multiple occasions, ManU lost Fergie yet we still didn't take advantage, Liverpool has emerged from their slumber and the Spurs are presently the better team in North London... if you find this acceptable, I feel for you and this future of this club... hope you all enjoy fighting with Everton and West Ham for the final Europa spot every year (aka the new Wenger Cup)

Wenger made a few changes today and you would think by his words that Arsenal were far the better team, but they were simply too tired to take advantage of the possession they had today.

I am not even going to go that far with the likes of Guardiola, Simeone, Heynkess, Fergusson, (SAD WENGER USED TO BE ON THIS LIST) watching the Chelskis game noticed Allardyce was making changes and bringing SUBS at the 58th minute (not 85) at least trying to change things against a team that was vastly superior, what WENGER does in these cases brings POLDI at the 85 minute and Campbell at injury time... well except against LIVERFOOL when he did all the wrong changes... The man has no ideas anymore, completely lost touch with reality and bringing still the World Cup (people already forgot who won it) as an excuse proves ito go that far with the likes of Guardiola, Simeone, Heynkess, Fergusson, (SAD WENGER USED TO BE ON THIS LIST) watching the Chelskis game noticed Allardyce was making changes and bringing SUBS at the 58th minute (not 85) at least trying to change things against a team that was vastly superior, what WENGER does in these cases brings POLDI at the 85 minute and Campbell at injury time... well except against LIVERFOOL when he did all the wrong changes... The man has no ideas anymore, completely lost touch with reality and bringing still the World Cup (people already forgot who won it) as an excuse proves iTO BE ON THIS LIST) watching the Chelskis game noticed Allardyce was making changes and bringing SUBS at the 58th minute (not 85) at least trying to change things against a team that was vastly superior, what WENGER does in these cases brings POLDI at the 85 minute and Campbell at injury time... well except against LIVERFOOL when he did all the wrong changes... The man has no ideas anymore, completely lost touch with reality and bringing still the World Cup (people already forgot who won it) as an excuse proves ito change things against a team that was vastly superior, what WENGER does in these cases brings POLDI at the 85 minute and Campbell at injury time... well except against LIVERFOOL when he did all the wrong changes... The man has no ideas anymore, completely lost touch with reality and bringing still the World Cup (people already forgot who won it) as an excuse proves it.

you could have a point there My dear old dad was having radio therapy last summer and the guy who drove him to his appointments has a 15 year old son in the youth team who quiet freely stated that in the dressing room the rumour is that Theo has lost his bottle and does nt want to injured again.Thing is he was in my opinion NEVER really that good he is great if he has no time to think about his last touch but give him that extra second and he fluffs his lines continuously He is also really really lazy and he really looks like he just cant be bothered and AW giving him a contract extension AND wage increase just shows how far from reality the changing room has become.

So I recognise the need for Wenger to go... it's gone too far, the club needs to continue to build on the recent changes, some of the players still need to be moved on and we need some real talent, ambition and character in the team.

Ronaldo was one of four changes to the team which beat Malaga at the weekend, but Gareth Bale's future at the Bernabeu was thrown into further doubt after he was again left out of the starting XI.

Meanwhile in the other changing room, Crooks was assembling by far his most conservative team selection to date, by lining up in a 4 -5-1 formation... is the pressure starting to tell?

As far as the team news is concerned, the former Chelsea boss may make a few changes to the starting XI that played in the last contest.

As far as team news is concerned, United are likely to make two changes in the starting XI that played against Hull City on boxing day.

We all knew we wouldn't get anything from this game.The venue tight ground, in London, more importantly the effect of the Norwich result.It seems to me now that our season could be determined by one player.Benik Afobe.He showed enough to warrant a start, Reading would be a great platform.We desperately need him to show the quality we know he has.With the predicted further 3 loses to come, this is going down to the wire.NES attitude has always been about his team, the system, style with little regard to the opposition, so it's too late for change, we have to carry on and hope that it will be enough.I saw a great tactic used in Spain, that would suit Costa or Cavellerio, who get frequently caught offside.That is for one of them to stay offside, as long as they are not involved in the first phase of play, then they are brought into the 2nd phase, with defenders tracking back, they have the advantage.Mind you it was Barcelona and Messi!!

Mauricio Pochettino says respect is key to his near perfect record against lower - league teams so far at Spurs - and that won't change as we face League One side AFC Wimbledon in the third round of the FA Cup on Sunday.

As far as the team news is concerned Argentina are set to go with the same lineup which took the field against Paraguay three days ago although we can expect couple of changes in Uruguay lineup as they will be looking to pack the midfield to counter Argentina's superior ball possession abilities.

Antonio Conte has made quite a few changes to his team in the FA Cup so far, but the line - ups he's named have become gradually stronger as the rounds went on.

Arsenal have looked very good in the competition so far this year, and although I don't think that simply changing the name on the competition really changes much about the team or what they need to do, perhaps there is something there for the players in terms of refreshing their minds and bodies a bit, altering their approach.

As far as Arsenal's team news is concerned, expect Wenger to make more than a few changes in the starting XI that played against Crystal Palace yesterday.

Although Klopp is wary of sweeping changes in team selection, preferring to keep the momentum of good results going, a further loss of points for Chelsea may change his perception.

«In New York City, we have made significant progress in many of our highest volume courts and our leadership team has made operational changes to set the stage for further improvement in those courts where we need to do better.»

The research team aims to develop and further understanding of the changing patterns, causes and consequences of fuel poverty through its broad and varied work programme, uncovering the circumstances and processes which lead households to be exposed to either cold and damp homes, or the achievement of a warm and dry home at the expense of other resources necessary for health and well - being.

Comparing the image of the Conservative party now with how it was seen back in 2003, it hasn't changed to a great extent — people think it has a better team of leaders (39 % think so, compared to 22 % back in 2003), is more competent (43 % now compared to 32 % in 2003) and is more united (46 % compared to 32 %), but in things like whether the Conservative party cares about the problems of ordinary people, shares peoples values, is honest and trustworthy or understands normal peoples lives, the improvement is far more meagre.

To further show that bacterial changes were playing a role, the team took stools from two responders and two non-responders and transplanted them into sterile mice.

All three teams found sections of DNA — haplotypes — that differed and ultimately pinpointed a single - letter difference that changed the amino - acid content of complement factor H. HapMap researchers say that refining the map further will speed up such discoveries, and they plan to release a new version this month that will include 4 million single - nucleotide variants.

To this end, the team considers their experimental and methodological framework useful for further inquiry into the complex nature of genomic changes.

To further explore the therapeutic potential of these receptors, Kalbe says his team are planning to obtain tissue from people with chronic airway diseases to compare them to healthy tissue, to observe if the receptors change in abundance or function in disease stateTo further explore the therapeutic potential of these receptors, Kalbe says his team are planning to obtain tissue from people with chronic airway diseases to compare them to healthy tissue, to observe if the receptors change in abundance or function in disease stateto obtain tissue from people with chronic airway diseases to compare them to healthy tissue, to observe if the receptors change in abundance or function in disease stateto compare them to healthy tissue, to observe if the receptors change in abundance or function in disease stateto healthy tissue, to observe if the receptors change in abundance or function in disease stateto observe if the receptors change in abundance or function in disease states.

The team found that two factors were much better at predicting range: A factor measuring the amount of length change possible in the vocal cord, or how far it could stretch, and a factor measuring the stiffness of the cord due to the fiber structures within.

«This long - term view shows that the next few decades offer a brief window of opportunity to minimize large - scale and potentially catastrophic climate change that will extend longer than the entire history of human civilization thus far,» the team concluded.

It's possible that climate change has strengthened the correlation between storm surge and heavy rainfall, but further analyses will be needed to make that case, the team notes.

«With the UCSF team, thanks to funding by public and private organizations, we're able to harness the team science model for collaborations like this that yield findings with the potential to change things for patients who've had very few options for far too long.»

They performed this identification at two points of time to study any changes that may have occurred, using «CLIP - seq,» an experimentally challenging procedure that, to Karginov and his team's knowledge, has not been used on mosquito tissues before, and that provides a large trove of potential microRNA - mRNA interactions for further investigation.

Although this line of research is far from contributing to changes in the clinic, the team now has a much better understanding of how RNA splicing is controlled in the ear.

The team is currently pursuing further studies of the impact of Part D cost - sharing policies in different disease areas, and hopes ultimately to get a better understanding not only of changes in drug access but also of the long range clinical outcomes and costs associated with any delays or interruptions in treatment.