Sentences with phrase «further characterization of»

Further characterization of Wac in vivo showed obligate haploinsufficiency for this gene (which encodes an autophagy - regulating factor) in a Pten - deficient context.

Further characterization of the subcellular expression and molecular function of Boule will help to discern the relationship between Boule and these other highly conserved germ cell proteins.

Though further characterization of the developmental and cellular defects in mouse Boule mutant testes is needed to determine the full extent of similarity in developmental and cellular defects between mouse and Drosophila Boule mutants [61], our data demonstrate a key physiological requirement of Boule in sperm development and conservation of its male reproduction function between two distant lineages of a protostome (Drosophila) and a deuterostome (mouse).

Further characterization of the object was undertaken by ALMA which traced carbon monoxide, allowing for detailed studies of star formation mechanisms in galaxies and for the motion of the material in the galaxy to be measured.

We are now expanding this facility to not only include state - of - the - art protein domain microarrays, but also to allow the further characterization of these protein - protein interactions in cells.

We expect that further characterization of this response will ultimately lead to identification of novel effective clinical interventions.»

«We need to investigate that possibility along with determining whether further characterization of both single CTCs and CTC clusters will provide further insight into differences in their biology, drug responsiveness and their contribution to the process of metastasis.»

Not exact matches

«There is enough grey in grey marketing law and the lack of federal government enforcement of labelling and packaging laws to prevent the characterization of the defendants» conduct as sufficiently egregious to attract further condemnation from the court,» Myers wrote.

And as a believer in the essential sanity and continuity of Western Civilization, Lewis would surely have concurred with Jaki's characterization of the Middle Ages: «In Western philosophy that was the first and thus far the last major epoch in which broadly shared respect was paid to the fundamental difference between ends and means....

This characterization is further enhanced by the activity of the magician, illegitimate priest as he was, who is commonly recognized to have been in some way ancestor of the modern scientist.

In this light Paul's characterization of love becomes far more significant than any list of special virtues.

I wouldn't normally call myself a progressive, since I tend to think of a progressive as being far left, but I am wondering what progressive means to you, and how you think of being a progressive as compared to other characterizations (moderate, left, far left, etc).

I'm a person who goes a little further than agnostic atheist, and state that certain gods or characterizations of god do not exist, but this is for reasons of that characterization is self - contradictory, and really impossible as stated in doctrine.

You said, «I'm a person who goes a little further than agnostic atheist, and state that certain gods or characterizations of god do not exist, but this is for reasons of that characterization is self - contradictory, and really impossible as stated in doctrine.»

No, his despair over sin, and all the more, the more it storms in the passion of expression, whereby without being aware of it in the least he informs against himself when he «never can forgive himself» that he could sin thus (for this sort of talk is pretty nearly the opposite of penitent contrition which prays God for forgiveness)-- this despair is far from being a characteristic of the good, rather it is a more intensive characterization of sin, the intensity of which is a deeper sinking into sin.

Astorino also took issue with Governor Cuomo's characterization of the budget deal as a roaring success, insisting it does not go far enough to boost the economy and help New Yorkers desperate for jobs and tax relief.

Pataki, who endorsed Rick Lazio for governor back in March, wouldn't go so far as to agree with the gubernatorial hopeful's characterization of Cuomo as «incompetent» — «I don't use words like that,» he told me.

Maloney, in a conference call later Wednesday, stood by his characterization of the anchorage proposal being dead despite the Coast Guard not going that far in its statements.

The team believes that the success of this optical detection can push the spectroscopy method even further, with the hope that this increased accuracy in detection and characterization of materials can be utilized in multiple scientific disciplines.

«This approach provides additional rapid characterization capability for emergency responders to radiological events, enabling further optimization of limited resources,» Hayes says.

Sbarra and colleagues sought to analyze two variables — how an observer's «situation» and «location» influenced their perception in order to improve the characterization of low macroseismic intensities felt near small earthquakes or far from larger ones.

Besides his smokescreen about «evenly distributed errors» (a phrase in which he has inadvertently provided us with an apt characterization of his whole book), Lomborgs further defense of his having presented an impossibly precise 43 percent value for a completely imprecise quantity is that he found it in somebody elses book: «Moreover, the 43 percent is actually described right off one of the best - selling college environment books by professor Miller is Holdren also claiming that he is wrong?»

Further insight into the basic details of CRISPR - Cas structure, functions, and biology — and characterization of new Cas effector proteins in particular — is crucial for optimizing and further expanding the diverse applications of CRISPR - Cas sFurther insight into the basic details of CRISPR - Cas structure, functions, and biology — and characterization of new Cas effector proteins in particular — is crucial for optimizing and further expanding the diverse applications of CRISPR - Cas sfurther expanding the diverse applications of CRISPR - Cas systems.

Confirmation of the biomarkers in other cancer types will facilitate further characterization and validation to provide mechanistic understanding of how and why these specific gene - targets become modulated to accentuate or inhibit tumor metastasis.

The exploration of the therapeutic potential of stem cells requires the characterization of their biological properties, the deciphering of the mechanisms that underlie their pluripotency and their capacity at differentiation, by the understanding of the signals that direct their fate towards discrete cell phenotypes... Their therapeutic use requests further, in particular in the case of substitutive therapies, the analysis of their capacities of integration in injured adult tissues and of their potential tumorigenicity, as well as the development of original ways of delivery.

Further phenotypic characterization revealed that LKB1 is required for the differentiation and maintenance of two NCC - derivatives, Schwann cells and the ENS. Using a model of neural crest stem cell line, we demonstrated that Lkb1 is key for neural crest - derived glial commitment.

While further characterization and extension is clearly needed, this approach appears offer great promise for the correction of age - related mitochondrial DNA mutations.

Additionally, characterization of Boule homolog (s) in the sea anemone, an outgroup to the bilaterian lineage, could provide further insights into the ancestral roles of Boule.

We discuss further work that correlates «flicker» with stellar density, allowing the application of astrodensity profiling techniques used in exoplanet characterization to many more stars.

In the first half of 2008, the EPOXI probe also carried out observations for its Extrasolar Planet Observations and Characterization (EPOCh) mission, which used its cameras to look for transiting exoplanets, observe the «wobbling» motions of stars with planets, and analyze the light reflected off the surfaces of far away planets (NASA press release; and Astronomy Picture of the Day).

The investigators identified 2,219 O - GlcNAcylated peptides from 1,045 glycoproteins, the most comprehensive characterization of O - GlcNAc modification sites so far.

Further, molecular devices can characterize a frozen cell in essentially arbitrary detail by removal and characterization of successive layers of material (atomically thin layers, if desired).

However, due to poor assembly of this locus in the Gallus Gallus v4 genome, accurate characterization has so far proven problematic.

This process typically includes assay development, high throughput screening, identification of «hits» that have activity in a test tube (or assay), characterization of hits and selection of leads for further optimization.

The study of antigenic targets of naturally - acquired immunity is essential to identify and prioritize antigens for further functional characterization.

Based on their initial levels of enhanced resistance to killing, yfgA and sapA mutants were selected for further characterization.

Sexy Beast manages to be the more visually arresting, as Glazer's talent for composition and impressionistic lighting furthers the intricacies of the film's characterizations rather than resting on sheer showboating.

The documentary aspect and the limited cast size thus far has also offered convincing, grounded characterization of the leads — and more importantly, characterization of their relationships.

It's just that a group of fifty - year - old dudes behaving like children can come across as past its prime comedy without further characterization.

He didn't start with an easy one either, as making such a far - fetched thriller fly requires a subtle touch and excellent characterizations, both qualities that he brings to bear without any appearance of awkwardness.

The film often goes too far in its ridiculous characterizations of the older mothers, to the point that its final act is essentially crippled by the sudden, emotional jumps that all the characters have to make.

His Joseph has been carried over (down to the animal abuse) from Considine's 2007 short Dog Altogether, and these origins in a far briefer work show in the vagueness of his characterization.

Beyond the characterization of its complex anti-heroine, though, I Kill Giants doesn't stray too far from an established collection of story beats, stretched thin over a slightly too - long 106 - minute run time.

Mann is by far the best part of The Other Woman with one of the better total - ditz characterizations, channeling Lucile Ball quite well, to grace the screen in recent years, taking what might have been stale and tired and making it feel very fresh and funny.

The Hollywood Reporter went so far as to report that Kennedy fundamentally disagreed with Lord and Miller's more comedic characterization of the young, scruffy - looking nerfherder played by star Alden Ehrenreich.

If you're an avowed Apatow fan, you will probably find Role Models, while falling short in terms of quality characterizations, doesn't fall far off the mark in its delivery of humor.

Keough takes this familiar characterization one step further — and pointedly distinguishes the performance from prestige television's appealing cadre of antiheroines — by bravely blocking us out from any deeper emotional connection.

Her demeanor and delivery are spot on and I found her characterization of Natalie far more intriguing than anyone else in the film.

Manhunter is a much more challenging film, deeper artistically, with far better characterizations, and is a breath of fresh air when contrasting it to the masterful, but darkly gothic Silence of the Lambs.

More distasteful are the screenplay's occasional detours into ersatz idol worship, like a monologue about bald eagles that slides a little too far into Tarantino territory and the Coen brothers - lite characterizations of secondary criminal characters, particularly that of Mood.