Sentences with phrase «further gene silencing»

Importantly, the small remnants of the messenger RNA can then function like additional microRNAs, binding to other copies of the messenger RNA, causing further gene silencing.

Not exact matches

And many companies began to crumble: While gene silencing was simple in worms, mammals proved to be far more complex — and safe drug delivery emerged as a major problem.

But so far, silencing genes using RNAi has not worked well in mammalian cells; although the approach has been successful in mouse embryos, double - stranded RNA shuts down synthesis of all proteins, not just the target gene, in other types of mammalian cells.

Since RNA - based gene silencing drugs have been successful so far, why bother with the greater challenge of targeting the DNA of the huntingtin gene itself, especially if it means dealing with virus particles and big, fragile drugs made of protein?

A group of scientists has redesigned and tested a harmless virus that can efficiently deliver a «gene silencing» message throughout the brain in mice, much further than naturally occurring viruses can reach.

So far, we've seen gene silencing drugs tested in several different animal models of Huntington's disease, successfully delaying symptom onset or even reversing symptoms.

In contrast, other gene silencing drugs with names like RNA interference, siRNA or shRNA, need to be injected directly into the substance of the brain and don't spread very far without help.

Taken further, food paves the way to keeping your genes in check by silencing the naughty genes of aging (such as mTOR and APOE4) and turning on the good genes (such as FOXO3, a longevity gene).