Sentences with phrase «further tumor model»

Not exact matches

Hingtgen's group is already testing how far their tumor - homing cells can migrate using larger animal models.

«This approach will hopefully lead to better mechanistic predictive modeling of response and future design of therapies that further take advantage of how the immune system recognizes tumors.»

The mouse model could also contribute to the further development of immunotherapies — a method in which the body's immune system is stimulated, so that it intensifies its fight against tumor cells.

A study combining tumor cells from patients with breast cancer with a laboratory model of blood vessel lining provides the most compelling evidence so far that a specific trio of cells is required for the spread of breast cancer.

Researchers used IL - 15 to develop a whole tumor cell vaccine to target breast (TS / A) and prostate (TRAMP - C2) cancer cells in animal models; results showed that tumor cells stopped growing after the vaccine was introduced and that beneficial effects were enhanced further when IL - 15Rα was co-produced by the vaccine cells.

Shah next plans to rationally combine the toxin - secreting stem cells with a number of different therapeutic stem cells developed by his team to further enhance their positive results in mouse models of glioblastoma, the most common brain tumor in human adults.

They further investigated this phenotype in a skin tumor model system, provided by Maria Sibilia from the Institute for Cancer Research of the Medical University of Vienna, and found that deactivating HDAC1 actually accelerates tumor development, while HDAC2 deactivation has no effect.

When the researchers removed FAK from blood vessels that grew in melanoma or lung cancer models, both chemotherapy and radiation therapies were far more effective in killing the tumors.

The researchers now have plans to conduct further work to explore the safety and effectiveness of the approach in vivo and in advanced lung tumor mouse models.

These GEMM - ESCs, with often multiple modified alleles, form the basis for further genetic engineering either by Flp - recombinase mediated integration, gene targeting or Crispr / Cas9 to allow for the evaluation of altered target gene expression in a spontaneous tumor model.

These results indicate the importance of assessing miR function in the complex physiology of in vivo model systems and indicate that further functional testing of miR - 342 is required before concluding it is a bona fide tumor - suppressor - miR.