Sentences with phrase «future clinical trials»

This would be an especially useful tool for gathering data in future clinical trials, they argue.

Large open data sets will improve the design of future clinical trials.

The results also highlighted trade - offs to consider in designing future clinical trials, he said.

However, the results suggest that future clinical trial research is needed to quantify the impact of a combined lifestyle intervention on ADHD symptoms.

According to the authors, the new findings provide a roadmap for future clinical trials for endometrial cancer.

The Angelman Syndrome Clinics also provide a foundation to support future clinical trials by having established sites with AS experts and patients in place to conduct those trials when they become available.

The described approach represents the first molecularly targeted treatment of NPM1mut leukemias by reversing a key mechanism of leukemogenesis and builds a basis for future clinical trials assessing these drugs in patients with NPM1mut leukemia.

The group's models could also help interpret data from future clinical trials that evaluate the effectiveness of booster shots in schoolchildren, «as well as predict the potential impact of new vaccination strategies,» he said.

«My team at Nationwide Children's has worked with commitment and dedication to develop a therapy that may subsequently be shown through future clinical trials to potentially alter the course of this unforgiving condition and provide a therapeutic option for the families and infants with SMA1,» says Jerry Mendell, MD, principal investigator in the Center for Gene Therapy at Nationwide Children's.

Based on these results, the researchers concluded that, for future clinical trials involving ibrutinib, the ABC DLBCL gene signature could be used to identify patients who would be more likely to respond to the drug.

McCormack says there's one upside of the failure: It informs future clinical trials.

Some of the factors that could affect the statements contained herein include: that PNP may not be able to enroll the required number of subjects in its Phase I clinical trial; that PNP or its sub-licensees may not be able to enroll the required number of subjects in planned future clinical trials, or that PNP may not reach any agreement with prospective sub-licensees or receive FDA approvals for further clinical trials.

Title: Determinants of antipsychotic response in schizophrenia: implications for practice and future clinical trials Author: J. Rabinowitz et al..

Cynthia Joyce, Executive Director for the SMA Foundation, added, «This pilot project has the potential to be a landmark study for therapeutics development — rapid completion will help make future clinical trials more efficient and more informative.»

Results of this study will be used to help design future clinical trials evaluating VSV - IFNβ - NIS in dogs with relapsed or refractory cancer.

But the implications of a recent study demonstrating this relationship are anything but simple and could influence both the design of future clinical trials and the goals of oncologists treating cancer.

Objective: The primary objective of the present study was to estimate how large a sample size would be needed for future clinical trials for AD - modifying treatments in Japan using atrophy measures of the brain as a surrogate biomarker.

Finally, these psychotic like symptoms will probably be used to select high risk samples in future clinical trials of interventions aimed at preventing the onset of psychosis.

This work confirms the translational potential of a PARP - 1 PET imaging agent and supports future clinical trials to test PARP - 1 expression as a method to stratify patients for PARP inhibitor therapy.

Using CT perfusion to identify which patients are more likely to benefit from a specific therapy, enables better patient selection and treatment planning, and also provides a biomarker for future clinical trials assessing new treatment options.

Our program is collaborating with researchers around the globe to dissect the results from this trial to inform basic research and design future clinical trials to translate a scientific milestone into an eventual public health tool.

«A future clinical trial for NMN will tell us if it has any efficacy in humans.»

«Thus, we hope that its potential as a powerful therapeutic agent for the treatment of autoimmune diseases will facilitate its use in future clinical trials.»

«The study results elucidate the molecular mechanisms underlying disease progression in multiple sclerosis models, providing a basis for future clinical trials to determine safety and efficacy of these chemical agents in humans with demyelinating disorders,» says Patrizia Casaccia, MD, PhD, Professor of Neuroscience, Genetics and Genomic Sciences at Mount Sinai and senior author of the study.

«Our research paves the way for future clinical trials that screen for AIM2 expression in colon cancer and possibly other cancers to identify patients who may potentially benefit from personalized anti-Akt therapy,» Wilson said.

According to the review, future clinical trials should optimize dosing, timing and duration of antidepressant treatment, trial size, patient selection, safety evaluation and reporting, procedure specificity, and assessment of movement - evoked pain relevant to postoperative functional recovery.

A simple dietary supplement (L - arginine) was found to improve birth outcomes, paving the way for future clinical trials to test this inexpensive and safe intervention.

The utility of Ciclopirox in patients with HIV, for instance after topical application to reduce sexual transmission of the virus, awaits verification in future clinical trials.

This challenge virus could be used in future clinical trials to test the efficacy of candidate dengue vaccines or therapies.

A new genetic therapy not only helped blind mice regain enough light sensitivity to distinguish flashing from non-flashing lights, but also restored light response to the retinas of dogs, setting the stage for future clinical trials of the therapy in humans.

Despite improvement in the rates of people dying of sepsis in the hospital, the condition is still a leading cause of hospital readmissions and costs, as well as long - term disabilities and impairments, prompting University of Pittsburgh and University of Michigan medical scientists to develop thorough recommendations for post-hospital recovery care and future clinical trials.

The U.S. Food and Drug Administration (FDA) has begun proceedings that could disqualify gene therapy researcher James Wilson of the University of Pennsylvania in Philadelphia from conducting any future clinical trials.

That said, they do suggest that future clinical trials may offer evidence on whether effectively treating RLS can stem the onset of heart disease, stroke, and kidney disease.

Calling their compound a new therapeutic candidate for people with severe asthma and other chronic airway diseases, researchers say with additional research and development their discovery could lead to future clinical trials for asthma, Cystic Fibrosis and Chronic Obstructive Pulmonary Disease (COPD).

Although further study is needed to determine exactly how interferon - alpha is crossing the blood brain barrier, the team's findings establish a basis for future clinical trials to investigate the effects of anti-IFNAR drugs on CNS lupus and other CNS diseases.

In future clinical trials, adding rapamycin could increase the therapeutic response.

A Houston Methodist team led by Mauro Ferrari, PhD and Jenny Chang, MD has received funding from the U.S. Department of Defense to complete preclinical efficacy studies and a future clinical trial testing a breast cancer precision drug.

At the Myotonic Dystrophy Foundation meeting in September, a session was held gathering patient input on central nervous system (CNS) symptoms, so that future clinical trials could track those symptoms more rigorously.

Here we review the data on anti — PD - 1 monoclonal antibodies to date and discuss ongoing and future clinical trials.

«We are looking forward to future clinical trials to test how this medication impacts blood flow in people.»

Being on a database of interested potential research volunteers is a great step, but there is no way to guarantee participation in any future clinical trial.

«If the findings are supported by future clinical trials in humans, then voluntary exercise could be considered as a way to improve the intellectual functioning of these children.»

Still, the study «certainly sets the stage for future clinical trials of drugs that show promise to (one day) improve the health of older adults.»

The basic discoveries emanating from this type of research can then inform the design of future clinical trials and ultimately improve the development of cancer immunotherapies, as well as our ability to target the patients who will have the best chance of benefiting from a particular treatment.

The press release quotes the Vice Chairman, Richard Mulligan, Ph.D, as saying «While we may evaluate PEG - SN38 in earlier lines of colorectal cancer treatment in future clinical trials, at this time, resources associated with such trials are better directed toward areas of study with nearer - term commercial potential.»

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