Sentences with phrase «future impact of disease»

Not exact matches

Important factors that could cause actual results to differ materially from those reflected in such forward - looking statements and that should be considered in evaluating our outlook include, but are not limited to, the following: 1) our ability to continue to grow our business and execute our growth strategy, including the timing, execution, and profitability of new and maturing programs; 2) our ability to perform our obligations under our new and maturing commercial, business aircraft, and military development programs, and the related recurring production; 3) our ability to accurately estimate and manage performance, cost, and revenue under our contracts, including our ability to achieve certain cost reductions with respect to the B787 program; 4) margin pressures and the potential for additional forward losses on new and maturing programs; 5) our ability to accommodate, and the cost of accommodating, announced increases in the build rates of certain aircraft; 6) the effect on aircraft demand and build rates of changing customer preferences for business aircraft, including the effect of global economic conditions on the business aircraft market and expanding conflicts or political unrest in the Middle East or Asia; 7) customer cancellations or deferrals as a result of global economic uncertainty or otherwise; 8) the effect of economic conditions in the industries and markets in which we operate in the U.S. and globally and any changes therein, including fluctuations in foreign currency exchange rates; 9) the success and timely execution of key milestones such as the receipt of necessary regulatory approvals, including our ability to obtain in a timely fashion any required regulatory or other third party approvals for the consummation of our announced acquisition of Asco, and customer adherence to their announced schedules; 10) our ability to successfully negotiate, or re-negotiate, future pricing under our supply agreements with Boeing and our other customers; 11) our ability to enter into profitable supply arrangements with additional customers; 12) the ability of all parties to satisfy their performance requirements under existing supply contracts with our two major customers, Boeing and Airbus, and other customers, and the risk of nonpayment by such customers; 13) any adverse impact on Boeing's and Airbus» production of aircraft resulting from cancellations, deferrals, or reduced orders by their customers or from labor disputes, domestic or international hostilities, or acts of terrorism; 14) any adverse impact on the demand for air travel or our operations from the outbreak of diseases or epidemic or pandemic outbreaks; 15) our ability to avoid or recover from cyber-based or other security attacks, information technology failures, or other disruptions; 16) returns on pension plan assets and the impact of future discount rate changes on pension obligations; 17) our ability to borrow additional funds or refinance debt, including our ability to obtain the debt to finance the purchase price for our announced acquisition of Asco on favorable terms or at all; 18) competition from commercial aerospace original equipment manufacturers and other aerostructures suppliers; 19) the effect of governmental laws, such as U.S. export control laws and U.S. and foreign anti-bribery laws such as the Foreign Corrupt Practices Act and the United Kingdom Bribery Act, and environmental laws and agency regulations, both in the U.S. and abroad; 20) the effect of changes in tax law, such as the effect of The Tax Cuts and Jobs Act (the «TCJA») that was enacted on December 22, 2017, and changes to the interpretations of or guidance related thereto, and the Company's ability to accurately calculate and estimate the effect of such changes; 21) any reduction in our credit ratings; 22) our dependence on our suppliers, as well as the cost and availability of raw materials and purchased components; 23) our ability to recruit and retain a critical mass of highly - skilled employees and our relationships with the unions representing many of our employees; 24) spending by the U.S. and other governments on defense; 25) the possibility that our cash flows and our credit facility may not be adequate for our additional capital needs or for payment of interest on, and principal of, our indebtedness; 26) our exposure under our revolving credit facility to higher interest payments should interest rates increase substantially; 27) the effectiveness of any interest rate hedging programs; 28) the effectiveness of our internal control over financial reporting; 29) the outcome or impact of ongoing or future litigation, claims, and regulatory actions; 30) exposure to potential product liability and warranty claims; 31) our ability to effectively assess, manage and integrate acquisitions that we pursue, including our ability to successfully integrate the Asco business and generate synergies and other cost savings; 32) our ability to consummate our announced acquisition of Asco in a timely matter while avoiding any unexpected costs, charges, expenses, adverse changes to business relationships and other business disruptions for ourselves and Asco as a result of the acquisition; 33) our ability to continue selling certain receivables through our supplier financing program; 34) the risks of doing business internationally, including fluctuations in foreign current exchange rates, impositions of tariffs or embargoes, compliance with foreign laws, and domestic and foreign government policies; and 35) our ability to complete the proposed accelerated stock repurchase plan, among other things.

As we face future known threats like war and climate change, and unknown threats like an asteroid impact or new disease, Downey said that that's the kind of knowledge we should want to have.

The Park District will replace the Ash Trees with a variety of trees in an effort to diversify its urban forest and in order to lessen the future impact of insect or disease.

«This is a promising approach to the fast response to disease, and could help counteract the negative impact of these conspiracy theories in future.»

This weather - based model was then used to predict the impact on severity of the disease of future weather scenarios for the period from 2020 to 2050.

Future work must continue to anticipate and monitor pathogen biodiversity and disease trends in natural ecosystems and identify opportunities to mitigate the impacts of climate - driven disease emergence.

«This study shines a light on the pathogenesis of inflammatory bowel disease and offers a positive impact on its future clinical management,» says Liu.

«We have addressed a concern in pregnant women with rheumatoid arthritis in terms of a potential increased risk of a negative impact of their chronic disease on the future health of their offspring,» said Jølving.

By studying how research funding is allocated relative to the global burden of disease, and assessing the outputs and impact of research, the resulting data will be used to better inform future investment decisions.

«Many thyroid diseases will be impacted by changing the expression levels of the thyroid - specific transcription factor, so we want to investigate FOXE1 more carefully in future work.»

«Given that the predominant thinking was that transmission was most likely to peak at very hot temperatures, which would mostly limit the diseases to the tropics, we were certainly surprised that the model and the field data suggested that high rates of transmission could occur at lower temperatures, possibly impacting more northern regions in the future,» Cohen said.

These effects are most relevant to policy makers keen to show the effectiveness of their interventions... Future work can assess the impact of SSB taxes on chronic diseases that would materialise later in time, such as heart disease, stroke, low back pain, and osteoarthritis, which would further strengthen the case for the SSB tax.

AIDS in Africa: Its Present and Future Impact by Tony Barnett and Piers Blaikie (Belhaven Press, pp 193, # 9.99) is a detailed and fascinating analysis of the effects of the disease on households, farming and industry in the continent first widely affected by AIDS.

«It's well established that psoriasis is associated with an increased risk for other comorbidities like chronic kidney disease, diabetes, and cardiovascular disease, but we don't yet understand how the severity of psoriasis impacts future risk of major health problems,» said the study's senior author Joel M. Gelfand, MD MSCE, a professor of Dermatology and Epidemiology at Penn..

-LSB-...] We expect that Sticky - trap and future related molecules will have significant impact on the field of tumour biology in local control of recurrent disease.

We thought that if we looked at vitamin D levels when the disease was inactive and then followed patients moving forward, the impact of baseline vitamin D levels on future events may be clearer.»

«In the future, such detailed digital models of diseases and the structure of organs could be used to help diagnose conditions, understand the impact of surgical interventions and even run digital drug trials.

As a part of investigating the mechanism of disease, HIV infection impact on immune function, testing concepts for future study as HIV cure strategies, and immune recovery after ART, researchers at the Wistar Institute, in association with Philadelphia FIGHT and the University of Pennsylvania, are collecting peripheral blood in order to establish a repository of persons living with HIV that can donate blood.

In one minute, you can change the future of health care, and have an enormous impact on reducing our chronic lifestyle driven disease burden that...

A growing body of research points to the need to understand how childhood trauma (commonly referred to as Adverse Childhood Experiences or «ACE's») impact a student's academic outcomes, social - emotional well - being and predict their likelihood of developing future chronic diseases.

He also had secondary changes to the size of his heart due to the disease, which could impact his health in the future.

This cardiac certification will potentially impact the long term health of dogs and cats, as well as, assisting breeders in screening for both congenital and inherited cardiac disease which will ultimately improve diagnosis, treatment and care in the future.

In light of the recent IPCC report released this past week and stating essentially that global warming is a runaway train that can't be stopped for centuries, it may be tempting to give up hope for a brighter future... But like any patient who suffers from a chronic disease that is potentially fatal, not only is education about the condition itself essential, but also what we can do to help mitigate its impact.

Smoke exposure increases respiratory and cardiovascular hospitalizations, emergency department visits, and medication dispensations for asthma, bronchitis, chest pain, chronic obstructive pulmonary disease (commonly known by its acronym, COPD), respiratory infections, and medical visits for lung illnesses.38, 43,160 It has been associated with hundreds of thousands of deaths annually, in an assessment of the global health risks from landscape fire smoke.38, 43,44,141,45 Future climate change is projected to increase wildfire risks and associated emissions, with harmful impacts on health.18, 161,162,10,163,164,36

Prevention initiatives have been cut, including Indigenous tobacco programs, and this will result in increased health care costs in the future as the impact of smoking, obesity and chronic diseases — significant contributors to the health inequality gap — grow.

Some recent topics that merit consideration and that have come to the surface include planning for and dealing with loved ones who have dementia — including though not limited to Alzheimer's disease; digital assets; biological assets; RESP provisions; loyalty cards provisions; companion animal / pet provisions; payment of estate administration tax (probate taxes and the impact of the new Ontario rules — Bill 173); the Granovsky Estate case and the future of multiple wills in Ontario; executor's insurance; and planning for embryos, cryo - preservation, cryonics and core blood — among other things.