Sentences with phrase «gain and loss hotspots»

For our analysis, we detected DNA gain and loss events using two distinct, yet complementary, methods from which we characterised DNA gain and loss hotspots.

In addition, we also measured how gene in DNA gain and loss hotspots associate with gene regulatory blocks (GRBs), genomic regions preserved between mammals and birds that are enriched for highly conserved elements [72].

First, we identified DNA gain and loss hotspots using the hotspot identification procedure described in the methods section.

Next, the genomic distribution for each set of time - specific DNA gain and loss hotspots were then compared by performing Fisher's exact test based on their overlap, hotspot overlaps were considered significant if their FDR was < 0.05.

Fourth, the observed autosomal divergence of gain and loss hotspot patterns in proximity to genes supports a model in which developmental / regulatory mechanisms (based on GO term results) are robust to large amounts of transposon driven DNA gain and loss.