Sentences with phrase «gain mechanistic»

Vertical integration is requisite to gain a mechanistic understanding of how genomic variation translates to phenotypes and fitness of organisms in their natural environment.

Our goal is to gain mechanistic understanding how altered expression or function of key mitotic regulators (e.g. GTPases, kinases) can give rise to genetically unbalanced cells that may initiate tumorigenesis.

The lab investigates consequences of epigenetic alterations in neuronal cancers and neurodegenerative diseases using a combination of biochemistry, cell and molecular biology with genome wide approaches to gain mechanistic insight into how chromatin architecture is modified in disease.

«Having identified a link between cytoskeleton dynamics and Zika virus replication, together with the plethora of available cytoskeleton - targeting compounds, might contribute to gain mechanistic insight into the ZIKV replication cycle and identify new avenues for treatment,» Bartenschlager says.

The ultimate goal of this line of investigation is to leverage these newly gained mechanistic insights for developing new therapeutics in a personalized manner based on one's unique genetic and / or pathway signatures.

Not exact matches

«This work provides the first demonstration of this combination of omics tools to gain a more mechanistic understanding of life in permafrost and the changes that occur during natural thaw,» said Jansson.

Now that the pieces are being connected and the role of prostaglandin is established, Wingert will turn attention to gaining a deeper molecular and mechanistic understanding of how the molecule works in kidney development, especially the gene targets of the signaling.

As researchers gradually gain more insight into the genome's hierarchy of structures, they will get closer to figuring out how this macromolecular wonder works in all of its vastness and mechanistic detail.

Hypothesis driven approaches to vaccinology can utilise the knowledge gained from mechanistic mouse models and our molecular understanding of intrinsic defects to human cells.5 However, caution is required when extrapolating data from murine models, as there are substantial differences between immune ageing in mice and humans.6 Nevertheless, model systems and ex vivo analyses of molecular alterations in aged human cells have identified multiple changes in the vaccination response with age and the aged immune system in general.

We want to gain comprehensive mechanistic insight into the division of human mitotic cells, provide a biophysical basis to understand nuclear organisation, and establish methods for systems analysis of the first mitotic divisions of mammalian embryos.

Knowledge gained from mechanistic studies may contribute to the design of allogeneic vaccine - based or adoptive immunotherapy for breast cancer.

So the folks at Gates have been trying to scientifically validate a teacher evaluation system that involves a mix of test score gains, classroom observations, and student surveys so that they can overcome resistance to centrally imposed, mechanistic evaluation systems.