Sentences with phrase «gain of function»

The variant is a naturally occurring gain of function mutation that has been shown to have 8 to 12 times greater activity levels than the wildtype gene.

Using chronically infected mouse models, as in the first study, the investigators found that while such gain of function does occur briefly, the epigenetic switches from its previous, exhausted state remain largely unchanged.

ERG abnormalities are evident by 5 — 6 weeks of age and cell degeneration is present by 4 months, suggesting the mutant protein has a toxic gain of function that severely compromises the early stage of development of the photoreceptors.

Earlier in his career, at the Erasmus Medical Center in Rotterdam, the Netherlands, Munster took part in the controversial «gain of function» experiments that engineered the lethal H5N1 bird flu virus to spread more readily among mammals — including, presumably, people.

Chondrocytes differentiated from TD - iPSC produced less cartilage than those from WT - iPSC and also had a lower proliferation rate and greater apoptosis, properties that were attributed to a gain of function by the mutated FGFR3.

This so - called «gain of function» of these two HARs in human embryos may point to differences in the development of key brain regions such as the cerebellum, which is known to regulate not only motor control but may also regulate higher cognitive functions, such as language, fear and pleasure.

Loss of function or gain of function) enables insight into the mechanism of disease and potential therapeutic targets.

The revelations at the C.D.C. renewed calls for a moratorium by opponents of such «gain of function» research.

This kind of research, like Kosinski's last major research on Facebook Likes, falls into a category close to «gain of function» research.