Discovered that deficits in inhibitory interneurons lead to reduced
gamma oscillatory activity, network hypersynchrony, and memory deficits in mouse models of AD.
Importantly, restoring Nav1.1 levels enhanced inhibitory cell — dependent
gamma oscillatory activity and cognitive performance in hAPP mice, revealing key roles for Nav1.1 and
gamma oscillatory activity in cognition.
Not exact matches
Finally, we assessed how the
oscillatory spectral profiles and theta -
gamma relationship observed at rest in left auditory cortex related to effects in the distributed language network during the movie.
These data suggest that the two groups had different electrophysiological spectral profiles in the baseline, which are characterized by a higher ratio of
gamma - band
oscillatory rhythm to slow
oscillatory rhythms for the long - term practitioners than for the controls.