Sentences with phrase «ganglion cell disease»

Not exact matches

Genetic diseases like retinitis pigmentosa destroy the photosensitive cells of the eye, the photoreceptors, but often leave intact the other cells in the retina: the bipolar cells that the photoreceptors normally talk to, and the ganglion cells that are the retina's output to the brain.

The drops protected the animals» retinal ganglion cells and optic nerves, both of which are generally damaged by the disease.

Nighttime restlessness is common among people with Alzheimer's, but now, scientists may have figured out why: The disease appears to degrade melanopsin retinal ganglion cells.

For example, if it turned out that you were losing ganglion cells that responded to motion early in the disease, then you can imagine designing visual field tests that would detect motion in particular and tell us whether or not people were losing certain kinds of ganglion cells long before pressure increases or holes in their visual field would show up.

Current biomarkers that we have for glaucoma, intraocular pressure or visual field, are indirect measures at best; what's really causing the disease is the loss of ganglion cell function.

Current therapeutic strategies for glaucoma, the most common cause of irreversible blindness [1], act only to manage the condition and there are currently no means to replace the retinal ganglion cells (RGCs) which are lost in this disease.

But the «off» retinal ganglion cell dendrites retracted very early in the disease.

For example, if you were testing a drug, or even monitoring the progression of the disease so that you could very finely tune the treatment to each individual patient, and so frequently and so quickly that you could prevent the loss of individual ganglion cells, you ultimately would be preserving vision.

So, intraocular pressure may be elevated, axon transport fails, the axon ends up being physically damaged; the retinal ganglion cells die relatively late in the disease.

Of course, the retinal ganglion cells and their axons are what degenerate in this disease.

Why that's important is that we showed that there are many changes in that retinal ganglion cell that are akin to what you see in other neurodegenerative diseases.

As a group, the Catalyst For a Cure research team was able to show that the primary cell that's affected in glaucoma, the retinal ganglion cell, does not die early in the stages of the disease.

What's important is that the CFC has shown that there are many changes in the retinal ganglion cell akin to what is seen in other neurodegenerative diseases such as Alzheimer's.

Neuroblastoma is a disease in which malignant (cancer) cells form in primitive nerve tissue called «ganglions» or in cells in the adrenal glands.

Leber Hereditary Optic Neuropathy (LHON) is a rare maternally inherited mitochondrial genetic disease, characterized by the degeneration of retinal ganglion cells that results in brutal and irreversible vision loss that can lead to legal blindness, and mainly affects adolescents and young adults.

The authors examine diseases associated with ganglion cells and discuss ideas for replacing or regenerating these cells.

CFC research findings have shown that there are many changes in the retinal ganglion cell akin to what is seen in other neurodegenerative diseases such as Alzheimer's.

These range from visual stimulation experiments that allow us to tap into the specific sets of retinal ganglion cells that are most vulnerable early in the disease, to the evolution of new imaging techniques, largely thanks to Alf Dubra and Vivek Srinivasan's work in those areas, and the ability to image retinal ganglion cells and their component parts like their axons which degenerate very early in glaucoma.

Martin Raff, MD: Glaucoma, in the end, is a disease of the retinal ganglion cells - the cells in the eye that send their nerve process to the brain, carrying information about vision.

So for the last 15 years I've been studying retinal ganglion cell biology trying to understand why they fail to survive after injury or in degenerative diseases like glaucoma and also when their connections to the brain are interrupted why do they fail to regenerate to regrow, why do they fail to repair themselves, it's this fundamental problem that leads to permanent vision loss in glaucoma.

What we've discovered is that those cells become active very early in the disease, they become active even before we can detect that the neuron is sick, even before the ganglion cell shows signs of degenerating, we find the glial cells are becoming very, very active and that was a surprise and we published those findings.

The team identified a period of vulnerability for retinal ganglion cells early in the disease, when these cells are more sensitive to metabolic insults and stressors.

Summary: Poor regeneration and reconnection of retinal ganglion cell (RGC) axons is a major obstacle for treating ocular trauma and diseases including glaucoma.

I think before they did that it was largely a mystery when and where ganglion cells dying during the progression of this disease.

Some eye diseases, including glaucoma, damage the retinal ganglion cells (RGCs) that make up the optic nerve.

The team will continue to develop and test an imaging - based biomarker that can be used in a clinical setting to enable us to understand the molecular changes to the ganglion cells, so we can detect the disease very early on.

Doctors determined that it was the result of Hirschsprung's disease, a congenital disorder that occurs when the inside of the large intestine lacks certain nerve cells, called ganglion, that help stool move along to the bowel.

A core pillar of research on the pathogenesis of eye diseases, like cataracts, glaucoma, and macular degeneration, has been on the role of mitochondrial dysfunction and death of retinal ganglion cells (RGCs).