Now research in mice is showing that human embryonic stem cells differentiated into medial
ganglionic eminence (MGE)- like cells, which produce GABA, may help alleviate two of the most severe side effects — chronic neuropathic pain and bladder dysfunction.
When we overexpress the homeobox transcription factor Dlx2, or the basic helix - loop - helix transcription factor Ascl1, we obtained neurons that exhibited action potential discharges typical for interneurons generated in the
medial ganglionic eminence, where these two transcription factors are also expressed during development.
Elevated tau is associated not just with Alzheimer's but with a range of lesser - known neurodegenerative diseases, such as progressive supranuclear palsy and
corticobasal ganglionic degeneration.
They are generally mixed cell tumors containing both
neural ganglionic cells (cells that arise from ganglion) and neural glial cells (they provide protection and nutrition to neurons and participate in the signal transmission in the nervous system).
Interneuron cell - based therapy in AD and related models: During brain development, embryonic interneuron precursors are generated in the
medial ganglionic eminence (MGE) and retain a remarkable capacity for migration and integration in adult host brains, where they fully mature into functional inhibitory interneurons.