Sentences with word «ganglioside»

When the team inserted the new analogues into a living cell and used high - definition, single fluorescent - molecule imaging, they were finally able to directly document the actions of specific gangliosides in a living cell for the first time.

The researchers observed how gangliosides form lipid rafts with cholesterol and a receptor protein called CD59.

To solve this enigma, the team focused on the behaviours of gangliosides: lipid molecules that were thought to play a central role in forming lipid rafts.

Some of these greasy molecules are reduced in HD, and a new study demonstrates that replacing one specific type, called ganglioside GM1, leads to dramatic improvements in the behavior of HD mice.

Researchers knew that the toxins simultaneously bind to two distinct neuronal receptors - one a protein and one a sugar - containing lipid called ganglioside — but the details of that binding had not been established prior to these studies.

Brunger and his colleagues found that the protein and ganglioside binding sites are quite distinct, although they are both necessary for the toxin to attach to the neuron and enter it.

They observed how gangliosides form raft domains with cholesterol and a protein, called CD59, which belongs to a special class of receptor proteins, called GPI - anchored receptors.

Using these new fluorescent analogs, combined with unique high - definition, single fluorescent - molecule imaging, the team was able to directly document specific ganglioside actions in a living cell for the first time.

However, scientists only vaguely understood how gangliosides work because, until now, they lacked probes that could accurately track the lipids» movements.

«Such dynamic behaviours were difficult to find using normal techniques, and our findings were made possible by single - molecule tracking of new fluorescent ganglioside probes,» said Kenichi Suzuki of the Institute for Integrated Cell - Material Sciences (WPI - iCeMS) and the paper's co-author.

When the enzyme can not function, GM2 ganglioside accumulates in neurons, causing seizures and cognitive and motor decline that begin at about six months of age.

The genetic mutations that cause Sandhoff disease affect an enzyme that breaks down the sphingolipid GM2 ganglioside.

The disrupted lysosomal degradation and resulting storage of HS and glycolipids such as gangliosides leads to severe neurodegeneration.

They determined which ones accurately mimicked real gangliosides, partitioning into rafts in the model system.

Previous ganglioside analogues (in which florescent dye is attached) did not partition into rafts, even in artificial model systems.

Previous analogs failed because they could not mimic the behaviours of native gangliosides even in artificial model systems.

In some cases, the antibodies that develop to help fight off the bacteria also signal the immune system to attack the body's own cells that bear gangliosides.

Hemorrhagic tumor necrosis during a pilot trial of tumor necrosis factor - alpha and anti-GD3 ganglioside monoclonal antibody in patients with metastatic melanoma.

The major projects include defining the role tumor derived gangliosides and oxidized lipid products play in altering the sensitivity of T cells to apoptosis, including their mechanism of action.

Either dominantly inherited mutations in MFN2 encoding mitofusin 2 or GDAP1 encoding ganglioside - induced differentiation associated protein 1 may be associated with mild neuropathy.

T - cell activation resulted in marked ganglioside elevation, as previously observed (7).

These structures are strongly modulated by the addition of low concentrations of cholesterol and ganglioside GM1 in the monolayer.

Without GLB1, a fatty substance or lipid called GM - 1 ganglioside accumulates abnormally in cells, especially in the nerve cells of the brain.

The disease causes an accumulation of lipids known as gangliosides, particularly in neuronal cells in the central nervous system.

In one well - studied example, the bacteria called Campylobacter jejuni, a common cause of food poisoning, carries a lipid molecule on its outer coat that resembles so - called gangliosides, molecules that help human nerve cells recognize and communicate with each other.

To solve this enigma, the team decided to look at the behaviours of gangliosides.

Specific lipids, such as Sphingomyelin and Gangliosides, in MFGM perform key roles that support infant brain development.

Researchers suspect the dyes were hydrophobic and altered how the ganglioside interacted with the cell membrane.

However, scientists only vaguely understood how gangliosides work because, until now, they lacked probes that accurately track ganglioside movements.

Gangliosides are lipid molecules that were proposed to play key roles in numerous biological processes, including the formation of raft domains, the entry of toxins into cells and chemical signal reception.

So, instead of just attaching a fluorescent marker to a ganglioside, the team chemically synthesized four whole gangliosides with fluorescent markers attached at specific locations.

Instead of just attaching a fluorescent marker to a ganglioside, the team chemically synthesized four whole gangliosides with fluorescent markers attached at specific locations.

The hematopoietic stem cell polarization and migration: A dynamic link between RhoA signaling pathway, microtubule network and ganglioside - based membrane microdomains.

It is caused by mutations in the GLB1 gene, which encodes an enzyme called beta - galactosidase necessary for the recycling of a molecule (GM1 - ganglioside) in neurons.

Both research groups also explored the role of the ganglioside binding site in the toxin's double - receptor binding.

When wheat binds to GM1 ganglioside on the intestinal surface, it induces the formation of auto - antibodies that attack the ganglioside in nerves.

One of the sialic acid - containing molecules gliadin binds to is called GM1 ganglioside.

During her studies at Oakland University, Dr. Dec participated in biochemical research to determine the antimicrobial activity of gangliosides.