Similar to Tam,
gefitinib blocked the hypoxic effect in ER - α — positive primary samples and cell lines but had no effect on ER - α — negative primary samples or cell lines (Fig. 2C).
Not exact matches
The lung cancer drug — called
gefitinib — helps by
blocking a protein that is known to encourage cell growth, and which was found to be present in high levels at the site of ectopic pregnancies.
Drugs such as
gefitinib and erlotinib are supposed to
block those growth signals in lung cancer cells, but not every cancer responds to them.
To assess whether this is occurring within breast cancer cells in response to hypoxia - induced activation of ER - α, EGFR signaling was
blocked with the inhibitor
gefitinib.