Sentences with phrase «gene activity at»

«A healthy lifestyle can regulate gene activity at a cellular and molecular level.

They assessed gene activity at time points known to correspond with key phases of disease: the «induction phase,» the time before the peak level of photoreceptor cell death; the «execution phase,» when the highest rates of photoreceptor cell death occur; and the «chronic phase,» during which photoreceptor cell death continues at somewhat reduced levels.

Interestingly, many of the genes identified in this study have been shown to have lower gene activity at the molecular level in autistic post mortem brain tissue samples.

«However, our new approach uses cutting - edge DNA sequencing technology to precisely measure the effects of thousands of sequences on gene activity at the same time.»

Not exact matches

What all these have in common is that, without any central control, individual units (genes, cells neurons or workers) respond to simple, local information, in ways that allow the whole system (cells, brains, organisms or colonies) to function: the appropriate number of units performs each activity at the appropriate time.

«We wanted to find out if obesity - related genes and activity level have an interactive effect on obesity risk — if there is a «double whammy» effect of being both at genetic risk and physically inactive, beyond the additive effect of these factors,» said Dr. Wood.

PER and TIM block the ability of CLOCK to turn on these genes at the same time as they are producing the oscillations of the central feedback loop — setting up extended patterns of cycling gene activity.

To get a better view of how this might occur, the researchers looked at gene activity in the anterior pituitary glands of foxes in a breeding program at the Institute of Cytology and Genetics in Novosibirsk, Russia, designed to study the evolutionary processes associated with domestication.

The team also looked at gene expression before and after exposure and identified 335 genes whose variation in expression correlated with caspase activity.

Base oxidation regulates gene activity In cooperation with colleagues at LMU, as well as researchers based in Berlin, Basel and Utrecht, Carell and his group have now shown, for the first time, that a standard base other than cytosine is also modified in embryonic stem cells of mice.

Much higher levels of gene activity were triggered in these experiments than scientists have achieved before, says Michael Hemann, a cancer biologist at MIT.

«Our stem cell - based studies indicate that low - calorie sweeteners promote additional fat accumulation within cells compared with cells not exposed to these substances, in a dose - dependent fashion — meaning that as the dose of sucralose is increased more cells showed increased fat droplet accumulation,» said Sabyasachi Sen, M.D., Associate Professor of Medicine at George Washington University in Washington, D.C. «This most likely occurs by increasing glucose entry into cells through increased activity of genes called glucose transporters.»

His team is now looking at patterns of gene activity in the four brains to work out whether it is possible to detect early signs associated with conditions like autism.

«People with this gene mutation usually get Alzheimer's at around age 70 because of the buildup of amyloids due to the reduced activity of the protective enzyme,» says Tanzi.

In a report that appears online in the journal Nature ¸ Dr. Arthur Beaudet, professor of molecular and human genetics at Baylor College of Medicine and a clinical geneticist at Texas Children's Hospital, and colleagues answer the question: «Can we turn on the activity of the paternal gene?»

Co-senior author Professor Jennifer Nichols at the Wellcome Trust - Medical Research Council Stem Cell Institute, said: «Our data allow us to study gene activity in individual cells to an unprecedented level of precision.

The seven - gene test is a vast improvement over earlier tests that look at the activity of hundreds of genes, the researchers said.

George Bray, who heads the clinical obesity and metabolism department at Louisiana State University, says environment and behavior — like lack of access to exercise facilities and overeating — so strongly affect gene activity that you can not focus on one while ignoring the other.

Scientists at the Allen Institute for Brain Science in Seattle are using microscopy to directly observe gene activity, one at a time, in razor - thin slices of mouse brain tissue.

Rather, «male differentiation requires two copies of a Z - borne gene, the expression or activity of which is sufficient for male development only at optimal temperatures,» the researchers write in the current Science.

The investigators confirmed the activity of genes at the newly identified loci by probing discarded corneal tissue from deceased individuals with and without Fuchs.

At the core of this cell behavior is how the loss of that single gene changes activation levels of dozens of other genes, suppressing genes associated with metastatic disease and increasing activity of genes linked to normal tissue.

Indeed, exposure of the protein produced by the nanoparticle - based gene therapy to the gut mucosa prevents inhibitor development and restores clotting - factor activity in mouse models of both haemophilia A and B. «This approach really could hold big benefit for patients,» says Jörg Schüttrumpf, a transfusion - medicine specialist who led one of the studies performed at the German Red Cross Blood Donor Service in Frankfurt.

Scientists of the Transfaculty Research Platform «Molecular and Cognitive Neurosciences» (MCN) at the University of Basel and the Psychiatric University Clinics have now described a network of genes that controls fundamental properties of neurons and is related to working memory, brain activity and schizophrenia.

«Our team studied thousands of molecular clues in each of these samples, sifting through extensive data on the activity of genes, proteins and other molecules to identify those of most interest,» says Katrina Waters, a biologist at PNNL and a corresponding author of the study.

So by looking at methylation patterns, the researchers could track if gene activity was cranking up or down.

«In this study we weren't looking at how repressing the gene activity affected the symptoms of the disease and this is obviously a critical question as well.

In their recent paper, the researchers not only looked at the genetic code, but also studied how gene activity varied between the two populations.

«For the first time, we can provide a complete description of an animal model from genes to behavior — including at the level of neuronal network activity, which has been ignored in most studies to date.»

The gene's activity is higher in hybrid males carrying at least one copy of the promiscuous species» version than in males with two copies the monogamous version.

«Clock genes» control our circadian rhythms, and the easiest place to extract evidence of their activity is from hair follicles, according to researchers at Japan's Yamaguchi University.

By revealing patterns of gene activity, the mouse atlas has allowed neuroscientists to identify functionally important regions that were invisible simply by looking at the brain's anatomy.

A second project, taking about a year to complete at a cost of $ 2 million, will make an atlas of gene activity in the mouse spinal cord.

«These findings are extremely important,» says political scientist James Fowler at the University of California, San Diego, who has been doing research linking certain gene variations to political activity.

MYCN and its kin are «transcription factors,» proteins that bind to DNA and influence the rate at which genetic information is used by the cell — essentially serving as brightener / dimmer switches for gene activity.

By looking at gene activity, researchers hope to develop a quick test for diagnosing harmful radiation exposure

«So, the flexibility of yeast cells does not arise from the activity or inactivity of a single gene,» project head at ISB, Dr. Aimée Dudley, explains.

«Our research focuses particularly on the activity of this gene and how it relates to neuroblastoma,» says Professor Marie Arsenian - Henriksson at the Department of Microbiology, Tumour and Cell Biology, Karolinska Institutet.

They identified 122 bacterial genes that increased their activity by at least threefold by the pressure change.

DNA microarrays, also called DNA chips, have stoked excitement in the research community because they can test the activity of many genes at once.

Because the RNAi wasn't used to dampen FOXP2 activity until 23 days after the birds hatched, the new study shows that the gene has a role beyond embryonic development, says neurogeneticist Simon Fisher of the University of Oxford in the U.K. «The gene, at least in songbirds, may have important active functions in [neural] circuits,» he says.

«I think this is going to be a fairly complex thing to work out,» Reeves says, adding that Ets2 encodes a transcription factor that influences the activity of at least 200 other genes.

At the end of 3 weeks, when the volunteers were waking up about 4 hours later than they used to, the activity of their hair follicle circadian genes had shifted too — but only by about two and a half 2 1/2 hours, the team reports online today in the Proceedings of the National Academy of Sciences.

At the time, Martin Cohn, an evolutionary developmental biologist at the University of Florida in Gainesville, discovered snake embryos had a different pattern of activity of certain genes than other reptiles and that applying a growth factor could make those embryos start to grow limbAt the time, Martin Cohn, an evolutionary developmental biologist at the University of Florida in Gainesville, discovered snake embryos had a different pattern of activity of certain genes than other reptiles and that applying a growth factor could make those embryos start to grow limbat the University of Florida in Gainesville, discovered snake embryos had a different pattern of activity of certain genes than other reptiles and that applying a growth factor could make those embryos start to grow limbs.

Still, Dudley feels that evolutionary genetic analysis can help identify the most relevant genes and pathological mechanisms at play in schizophrenia and possibly other mental illnesses that preferentially affect humans — that is, neurodevelopmental disorders related to higher cognition and GABA activity, including autism and attention - deficit / hyperactivity disorder.

Hundred of genes can influence the activity of other genes at any given time.

Surprised by these day - night changes in gene activity, the team decided to analyse data collected by a specialist burn injuries unit at the University of Manchester, UK.

«I think you'll see a flurry of activity to look at this gene and its partners,» Manji says.

Joanna Wysocka and her colleagues at Stanford University in California made the unexpected find while they were analysing gene activity in 3 - day - old human embryos, which are bundles of eight cells.

The researchers looked at the activity of 112 genes in diseased retinas and compared it to gene activity in normal retinas.