Sentences with phrase «gene affected in»

Their preservation in the zebrafish allows us to visualize in this transparent genetic vertebrate model whether these variants are just neutral or if they disrupt the regulation of one the neighbor genes, possibly revealing the actual gene affected in AMD human patients.

For example, 16 of the genes affected in the rats have analogs in humans, and those genes are linked to a predisposition for Alzheimer's, the study reports.

Not exact matches

In Kilgrave's case, for example, the gene therapy would need to be done extensively until all of his millions of affected cells were treated, something that's quite unlikely.

But what's really significant in the research is the identification of which genes are selectively affected by consumption of dietary fat or by capsaicin.

Moshe Szyf, a molecular biologist at McGill University, discusses the way parental licking and grooming affects the expression of certain genes in rat pups.

Neuroscientists have over the past decade uncovered evidence, both in rodent and human studies, that parental caregiving, especially in moments of stress, affects children's development not only on the level of hormones and brain chemicals, but even more deeply, on the level of gene expression.

Parenting styles can be affected by both maternal and paternal genes in combination with the environment.

According to a 2006 article published in the «American Journal of Human Genetics,» mutations and genes can affect tooth development.

The scientists were interested in understanding what factors influenced women to share test results, particularly with their children, who might also be affected by the cancer - conferring genes.

Moderate level fetal alcohol exposure and serotonin transporter gene promoter polymorphism affect neonatal temperament and limbic - hypothalamic - pituitary - adrenal axis regulation in monkeys.

Scientists also speculate that natural chemical changes in our genetic material may affect the way certain genes dominate.

They examined whether there were differences in the composition of the breast milks» microRNAs, snippets of RNA that affect gene expression and can be passed to the infant.

These conditions are each caused by mutations in a particular gene, and affect different enzymes involved in breaking down galactose.

When looking into mechanisms that might affect the levels of SMN protein in neurons, the researchers scanned a genomic database called the UCSC Genome Browser and identified two genetic sequences that matched the opposite DNA strand of the SMN gene.

But over the past decade, researchers have identified hundreds of gene variations that seem to affect brain development in ways that increase the risk of autism.

For Molly Schumer, a postdoctoral fellow in genetics and evolutionary biology at Harvard Medical School, the fellowship will help fund her research on how evolutionary forces affect our genes, focusing in particular on a persistent trait that can cause melanoma in swordtail fish.

But when a mother passes these genes to her sons, they are not protected in the same way and thus will be affected.

McCallion's strategy to make sense of all this data looks at the active genes in cells affected by a disease, groups of genes that interact with one another, their vulnerability to mutation and information from past scientific studies to filter more than a thousand gene candidates for disease risk down to just a handful within any one implicated region.

In individuals affected by SMA, the survival motor neuron - 1 (SMN1) gene is mutated and lacks the ability to process a key protein that helps neurons function.

Before this can happen though, Teixeira said that his team will first have to determine whether the Stk11 gene or the other genes and proteins it controls are similarly affected in the human form of BPH.

Because this imprinting affects hundreds of genes that are non-coding, including microRNAs and non-coding RNAs, it's a very interesting fine - tuning mechanism for the dosage of gene expression in the brain and elsewhere in the body.»

At best, the scientists say, there is a 50 - 50 chance that the gene closest to a mutation will even be active in the cell types affected by a disease.

These are small molecules that can affect the way genes work, and the types of microRNA in our blood are known to vary according to age.

Additionally, the agency would continue efforts to advance precision medicine and cancer genomics in support of the Million Veteran Program (MVP), which aims to collect blood samples and health information from one million veteran volunteers to study how genes affect health.

The goal of early SMA drug discovery programs has been to identify small molecules that induce the SMN gene to produce sufficient levels of protein to improve motor neuron functioning in affected patients.

The same genes are often affected in the same diseases in both species.

Examples of gene networks in the hippocampus affected by brain trauma.

Standard approaches also struggle to find combinations of multiple genes that affect disease risk in complex ways (known as genetic interactions).

In fact, sewage treatment methods used at the country's 18,000 - odd wastewater plants could actually affect the resistance genes that enter their systems.

«This is exciting because if genes affected differences between individuals in these traits, it means they could also change in response to natural selection,» said Dr Bolund.

Because of either a genetic mutation or environmental factors that affect how the gene directs the protein's development, some people's oxytocin receptors may be folded up in ways that prevent them from binding well to the hormone.

The study, which is published in the journal Molecular Psychiatry, describes a possible mechanism for how the gene variant produces clinical symptoms by affecting levels of specific proteins in the brain.

«It's sort of the tip of the iceberg,» says Uitterlinden, who led one of four groups that identified several variations in a gene called LIN28B that affect the timing of girls» first period, or menarche.

More and more, researchers are finding that an extra bit of a vitamin, a brief exposure to a toxin, even an added dose of mothering can tweak the epigenome — and thereby alter the software of our genes — in ways that affect an individual's body and brain for life.

Using a novel form of gene therapy, scientists from Harvard Medical School and the Massachusetts General Hospital have managed to restore partial hearing and balance in mice born with a genetic condition that affects both.

Now, new research suggests changes at the epigenetic level — specifically alterations in proteins that affect gene expression, rather than genetic mutations — could be driving childhood ependymomas.

Complex traits like the ones in the study are each influenced by many different genes, while at the same time, several different traits can be affected by the same genes.

Dwivedi cautioned, however, that each miRNA can affect many different genes, so its involvement in depression may not be clear - cut.

He identified gene mutations in breast cancer cells that affect their ability to recognize viruses, including some mutations that would be expected to significantly increase the cells» vulnerability to viruses implicated in breast cancer.

We have identified hundreds of genetic variations associated with autoimmune diseases that appear to affect the activity of genes in specific regions of the genome, pointing to biological pathways that may be involved in disease and which, ultimately, may be treatable with medication.»

Researchers then tested cell cultures and mouse models by using a gene editing process called CRISPR - Cas9 to demonstrate how the presence or absence of myomaker and myomerger — both individually and in unison — affect cell fusion and muscle formation.

But as some miRNAs regulate many different genes, and each gene is affected by many different miRNAs, their exact role in cancer is tough to pin down.

The researchers also found that four of the affected genes in the hippocampus and one in leukocytes are similar to genes in humans that are linked to PTSD.

Why SIRT6 didn't affect females is a puzzle, but may be related to differences in genes that regulate ageing in males and females (Nature, DOI: 10.1038 / nature10815).

In comparison with African strains, infection by the Asian strain of Zika virus more potently affected the p53 gene and genes connected with cells» responses to viral infection, such as interferons.

Comparisons of the Neandertal genome to the genomes of five present - day humans from different parts of the world identify a number of genomic regions that may have been affected by positive selection in ancestral modern humans, including genes involved in metabolism and in cognitive and skeletal development.

The newly identified gene affects accumulation of amyloid - beta, a protein believed to be one of the main causes of the damage that underpins this brain disease in humans.

By tracking activity in almost all the genes of a free - living archaeon — which, like a bacterium, is a prokaryote — Bonneau was recently able to piece together how the genes affected one another's expression, enabling him to map the organism's «control circuit» as if it were a machine.

Unlike other autoimmune disorders with associated risk factors, APECED is clearly caused by a mutation in a single gene, based on analyses of affected families.

«Antibiotics use affects the abundance of resistant bacteria in soil: The use of animal manure increases the soil content of antibiotic - resistant genes.»