«We hope to shed light in this black box to reveal how
the genes affect the cells» identity and behavior.»
Not exact matches
In Kilgrave's case, for example, the
gene therapy would need to be done extensively until all of his millions of
affected cells were treated, something that's quite unlikely.
Charlie inherited the faulty RRM2B
gene from his parents,
affecting the
cells responsible for energy production and respiration and leaving him unable to move or breathe without a ventilator.
McCallion's strategy to make sense of all this data looks at the active
genes in
cells affected by a disease, groups of
genes that interact with one another, their vulnerability to mutation and information from past scientific studies to filter more than a thousand
gene candidates for disease risk down to just a handful within any one implicated region.
At best, the scientists say, there is a 50 - 50 chance that the
gene closest to a mutation will even be active in the
cell types
affected by a disease.
This allows researchers to randomly screen the entire genome for
genes that
affect cell survival.
He identified
gene mutations in breast cancer
cells that
affect their ability to recognize viruses, including some mutations that would be expected to significantly increase the
cells» vulnerability to viruses implicated in breast cancer.
Researchers then tested
cell cultures and mouse models by using a
gene editing process called CRISPR - Cas9 to demonstrate how the presence or absence of myomaker and myomerger — both individually and in unison —
affect cell fusion and muscle formation.
In comparison with African strains, infection by the Asian strain of Zika virus more potently
affected the p53
gene and
genes connected with
cells» responses to viral infection, such as interferons.
Yang said the study not only indicated which
genes are
affected by traumatic brain injury and linked to serious disease, but also might point to the
genes that govern metabolism,
cell communication and inflammation — which might make them the best targets for new treatments for brain disorders.
However, microgravity can reduce
cell growth, alter
gene expression and change the pattern of root growth — all aspects which critically
affect plant cultivation in space.
They generated an experimental model to investigate how one of the
genes commonly mutated in blood
cells of elderly humans, TET2,
affects plaque development.
They found 204 that reactivated
cell proliferation, including two that
affected nearly 2000
genes.
The result was the largest deletion ever observed in the dystrophin
gene using CRISPR / Cas9, and the study was the first to create corrected human iPS
cells that could directly restore functional muscle tissue
affected by Duchenne.
The stem
cell gene therapy could be applicable for 60 percent of people with Duchenne, which
affects approximately 1 in 5,000 boys in the U.S. and is the most common fatal childhood genetic disease.
«Our research has identified a
gene affecting another type of ischemic stroke, due to small vessel disease, and also suggests some
genes may be associated with both ischemic and hemorrhagic stroke and may act through a novel pathway
affecting pericytes, a type of
cell in the wall of small arteries and capillaries.
In the early 2000s,
cell biologists linked cyst formation to
gene mutations that
affect the primary cilia, hair - like projections from
cells that seem to act as sensory antennae.
The new work, published today in
Cell Reports, finds that the protein ADR - 1 binds to messenger ribonucleic acid, or mRNA, and then enhances RNA editing, a process that allows a
gene to be present as multiple mRNAs that can then each
affect gene expression differently.
The findings highlight specific sets of
genes and the brain
cells they
affect as being involved in regulating anxiety.
This epigenetic alteration of
gene activity in brain
cells that receive this neurotransmitter showed for the first time that dopamine deficiencies can
affect a variety of behavioral and physiological functions regulated in the prefrontal cortex.
A process that wipes egg and sperm
cells clean misses some
genes out, explaining how your bad habits may
affect the DNA of your children and grandchildren
Among these is a substance, called EZH2, that
affects the expression of a wide variety of
genes, including those involved in
cell development and differentiation.
To better understand how HMGA1
affected the rodents» intestines, Resar and Lingling Xian, M.D., Ph.D., research associate at the Johns Hopkins University School of Medicine, and their colleagues examined the transgenic animals» intestinal
cells to determine which ones were expressing this
gene.
This analysis, done on separate samples from the same patient, revealed that many of the
affected genes confer advantages to cancer
cells by, for example, enhancing
cell migration or resistance to chemotherapy.
The aberrant and ongoing activation of ERVs caused an accumulation of retroviral proteins in the
affected cells and deregulation of
genes and pathways.
Publishing in Nature, the study reports that genetic alterations
affecting a part of the PD - L1
gene increases the production of the protein, allowing cancer
cells to escape detection by the immune system.
«By identifying the full set of
genes in each of these two
cell types, we provide detailed information that taste scientists can use to help understand how these
cells work, both when healthy and also when
affected by damage or disease.»
This work, conducted by Yuliang Wang, now a senior research associate at Oregon Health & Science University, uncovered intriguing differences involving
genes that
affect the
cells» metabolism.
Publishing in Nature, a recent study reports that genetic alterations
affecting a part of the PD - L1
gene increases the production of the protein, allowing cancer
cells to escape detection by the immune system.
The team also found five
genes in domestic cats that influence the migration of neural crest
cells, stem
cells in the developing embryo that
affect everything from skull shape to coat color.
Unlike genetic mutations that
affect DNA and the genome, epigenetic markers turn
genes on and off to regulate
cell processes, which if altered may lead to disease, he explains.
The research suggests that reducing production of the protein, called myoferlin,
affects cancer
cells in two primary ways: by changing the activation of many
genes involved in metastasis in favor of normal
cell behavior, and by altering mechanical properties of cancer
cells — including their shape and ability to invade — so they are more likely to remain nested together rather than breaking away to travel to other tissues.
The work, published online this week in the journal Nature, suggests modulation of «enhancer - directed RNAs» or «eRNAs» could provide a new way to alter
gene expression in living
cells, perhaps
affecting the development or pathology of many diseases.
«Scientists determine structure of enzyme linked with key
cell - signaling protein: Findings aid understanding of how modifications to
cell - signaling protein
affect its action in turning
genes on and off.»
«Because many broadly expressed
genes that play key roles in essential cellular functions are under the control of
cell - specific enhancers, the ability to
affect enhancer function by knocking down eRNAs could potentially provide a new strategy for altering
gene expression in vivo in a
cell - specific manner,» said Glass, noting that in his research, anti-sense oligonucleotides were developed in conjunction with Isis Pharmaceuticals, which suppressed enhancer activity and reduced expression in nearby
genes.
In one experiment, the researchers created arrays of mammary epithelial
cells and asked how adding one or more
cells expressing low levels of the cancer
gene RasG12V
affected the
cells around them.
Further analysis showed that wild type HIV - 1 tends to integrate itself into or near
genes affecting CD4 + T
cell activation and metabolism more frequently than does the mutant strain.
HIF regulates
genes that dictate how the human body responds to a lack of oxygen, he said, but it can also
affect genes that determine whether a
cell divides and how that
cell can
affect neighboring
cells.
Molecular analysis showed that heart
cells in
affected animals were poorly developed and had mitochondrial defects, indicating that Sap130 - Pcdha9
gene interactions play a crucial role not only in heart development but also in regulating metabolic function of the cardiac muscle.
The researchers also tested how the loss of HSF1
affected mouse
cells carrying either of two cancer - inducing mutant
genes.
The study reveals that the mutated
gene affects a key housekeeping process that is required for removing unwanted molecules from
cells in the body.
It now appears that the clocks and clock - related
genes — some 20 such
genes have been identified —
affect virtually all of the
cells» metabolic pathways, from blood sugar regulation to cholesterol production.
Research from other scientists at Johns Hopkins, he says, had suggested that some tumors, particularly those that
affect the nervous system, have mutations in the ATRX
gene, which produces proteins that appear to maintain the length of telomeres, repetitive segments of DNA on the ends of chromosomes that typically shorten each time a
cell divides.
Using novel technologies developed at HMS, the team looked at how a single sensory experience
affects gene expression in the brain by analyzing more than 114,000 individual
cells in the mouse visual cortex before and after exposure to light.
With this type of cancer, the
genes in the white blood
cells affected change slightly, causing two chromosomes to cross.
Howard Hughes Medical Institute (HHMI) scientists have profiled key features of the genetic material inside three types of brain
cells and found vast differences in the patterns of chemical modifications that
affect how the
genes in each type of neuron are regulated.
At Emory, the pause has halted not only the CEIRS project with the lab - attenuated PR8 strain, but also a research grant project headed by Anice Lowen that is looking at how the
cell types targeted by two different influenza viruses
affect their propensity to exchange
genes.
Although the biological mechanisms through which this polymorphism could
affect aging are not known, it is adjacent to two
genes called CDKN2A and CDKN2B, which play an important role in
cell cycle regulation.
«Mapping the
genes that increase lifespan: Comprehensive study finds 238
genes that
affect aging in yeast
cells.»
In the study, which began in 2011, an adeno - associated virus vector was used to carry a functional copy of the
affected gene to muscle
cells in the diaphragms of nine patients.