Sentences with phrase «gene alterations»

There were no significant differences in the frequency of the other gene alterations examined between the two types of cancer.

I believe there are three highlights: frequent gene alterations in TNBC, under - representation of mutations in mRNA sequences, and a continuous distribution of mutation frequencies within tumors.

Already, a few examples exist — blood tests for hereditary colon cancer; the design of Herceptin, a breast cancer drug; and Gleevec, a drug used in chronic myelogenous leukemia — in which the identification of gene alterations translated into clinical applications.

Among patients with non-small cell lung cancer (NSCLC) fueled by ALK gene alterations who were being treated with crizotinib (Xalkori), a decrease in the number of circulating tumor cells (CTCs) harboring increased copies of the ALK gene over the first two months of treatment was associated with increased progression - free survival.

The new study led by Vanderbilt - Ingram Cancer Center (VICC) investigators has identified gene alterations that may explain why TNBC is resistant to most existing treatments, and suggests that a targeted therapy currently in clinical development may prove beneficial.

It is not enough to rely on the characteristics of the primary tumour because brain metastases have other specific gene alterations and in many patients this gives us better treatment alternatives.»

The researchers performed the studies using mice bred to carry gene alterations that disrupt the production of the same mitochondrial enzyme that is defective in patients with MMA.

They simply used the jellyfish gene, which is easily detected, to test whether inserting foreign genes into eggs (so - called germline gene alteration) can produce viable monkeys.

Independent identification of ERBB2 gene alterations was completed and frequency of that alteration, as well as others in the PTEN, PIK3CA and TP53 genes, were determined.

The researchers used gene - sequencing technology to determine the most common gene alterations associated with the cancers and then used their test to find and extract from the fluid cancer the DNA specific to each cancer.

Exome sequencing alone detected driver gene alterations in 26 % of tumors, compared to 72 % by genome sequencing.

Gene Alterations Linked to Poor Outcomes in A Pediatric Cancer A survey of the neuroblastoma cancer genome revealed alterations in two genes, ARID1A and ARID1B, associated with a poor prognosis.

Many of the major cancer - causing gene alterations, such as MYC, TP53, or KRAS, are not directly druggable (2 — 5).

According to combined results from the two trials, the investigational anticancer therapeutic entrectinib — which targets a family of proteins called TrkA / B / C, ROS1, and ALK — was safe and tolerable and showed signs of clinical activity in patients who had several different types of cancer with NTRK1 / 2/3, ROS1, or ALK gene alterations and who had not previously been treated with Trk -, ROS1 -, or ALK - directed targeted therapeutics.

With this information, the NYGC and Watson collaborated to identify gene alterations that can be therapeutically targeted.

Epigenetics: The Less Understood DNA Alteration Epigenetics is the study of gene alterations that occur without mutating the DNA.

The researchers then looked for de novo mutations, gene alterations that appear spontaneously in one's offspring and are due to a mutation in a father's sperm or a mother's egg.

Along with differences in gene alterations, bladder cancer patients also show differences in how well they respond to certain therapies.

Because these embryos are not viable, the gene alteration would not be considered germline editing according to guidelines issued after an international summit in December.

Several common single - gene alterations have been observed in glioblastoma.

In 2002, they discovered that the gene alteration makes brain cancer cells more responsive to anticancer drugs known as alkylating agents.