Sentences with phrase «gene amplification»
Gene amplification refers to a process in which multiple copies of a specific gene are produced within a cell. It is like making duplicates of a gene to increase its quantity. This can happen naturally or be induced by scientists. Gene amplification is important for various cellular functions and can be used in genetic engineering or medical research. Full definition
An average of 42 percent of mutations and 63 percent of gene amplifications differed between primary and metastatic sites.
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A team of scientists, led by Jill L. Maron, MD, MPH, Associate Professor of Pediatrics at Tufts Medical Center, reports that by combining gene amplification techniques with advanced computational analysis tools they were able to identify and validate salivary biomarkers to predict oral feeding readiness in preterm infants.
The IQFISH panel for lung cancer is a set of oligonucleotide - based FISH probes, premixed with IQFISH Buffer, for the detection of rearrangements involving the ALK, ROS, and RET genes, and the detection of MET gene amplification by fluorescence in situ hybridization (FISH).
In 1974, he undertook graduate work with Brian Hartley at Imperial College London, studying gene amplification in bacteria.
He received his Ph.D. in pharmacology from Stanford University, where he studied gene amplification as a mechanism by which cells become resistant to anticancer agents.
Gene amplification confers glyphosate resistance in Amaranthus palmeri, a study by Philip Westra, et.
It is the first study to find a molecular cytogenetic basis of EPSPS gene amplification in kochia.
This could be combined with fluorescence in situ hybridisation (FISH) analysis to detect gene amplification.
A team at Technical University of Munich has now shown that those characteristics can be explained by specific gene amplifications which occur along various evolutionary pathways of the cancer.
One type of mutation is called gene amplification, in which multiple copies of the ESR1 gene are present.
Sample processing, 16S rRNA gene amplification, and 454 pyrosequencing was performed following protocols benchmarked as part of the Human Microbiome Project [33], [34].
An Open Label, Phase II Study of Neratinib in Patients with Solid Tumors with Somatic Human Epidermal Growth Factor Receptor (EGFR, HER2, HER3) Mutations or EGFR Gene Amplification
Gene amplifications characterize acral melanoma and permit the detection of occult tumor cells in the surrounding skin.
Previous research (the Gynecologic Oncology Group's GOG181B trial) has suggested that trastuzumab is inactive in HER2 / neu - expressing endometrial carcinomas, and in the current study, nearly half of the participants «ultimately did not have tumoral HER2 / neu gene amplification,» Dr. Santin said.
[38,41] While gene amplifications are rare in cutaneous melanoma, they are present in approximately 85 % of mucosal melanomas.
He was a Helen Hay Whitney fellow with Nobel Laureate Dr. Phillip Sharp at the Center for Cancer Research at the Massachusetts Institute of Technology (M.I.T.), where he developed gene transfer technologies based on gene amplification and expression in mammalian cells.
It is noteworthy that, in our initial virus gene amplification screening, a hypothesis for PCR primer design, based on an early report that EEEV causes egg - drop in turkey [12], helped us have obtained BYDV gene fragments.
Gene amplification usually leads to increased expression of the encoded protein in cells.
32) Kubo T, Yamamoto H, Lockwood WW, Fujii T, Ouchida M, Soh J, Takigawa J, Kiura K, Shimizu K, Date H, Minna JD, Lam WL, Gazdar AF, Toyooka S (2009) MET gene amplification or EGFR mutation activate MET in lung cancers untreated with EGFR tyrosine kinase inhibitors.
The research team used single - gene amplification to study the gene responsible for HIV's major surface protein, env.
One strategy is already known to be effective for patients with the gene amplification.
In fact, the discovery of the gene amplification may explain a long - known but mystifying paradox.
Cedric Notredame, Senior Principal Investigator at the Centre for Genomic Regulation in Barcelona, who directed the comparative genomics part of this study explains: «The notion that gene amplification is a highway for adaptation has long been around, but our work shows that in Leishmania, evolution has scaled up this mechanism to the point of making it an essential part of the parasite life cycle.
«However, it may be that gene amplification is more susceptible to treatments based not on TKIs but on antibodies,» Garcia says.
CFSs are indeed involved in the formation of chromosome rearrangements found in tumor cells (deletions, gene amplifications).
It has been observed that c 4 (CDK4) gene amplification, is an independent oncogene, and is more common in acral and mucosal melanoma than the CSID and NCSID cutaneous melanomas [20, 47].
«HER2 overexpression or gene amplification is widely known to be associated with sensitivity to HER2 - targeting drugs (trastuzumab, lapatinib, pertuzumab, and T - DM1) in breast cancer.»
Gene Amplification Can Correct a Photosynthetic Growth Defect Caused by mRNA Instability in Chlamydomonas Chloroplasts
· The gene amplification technique used by the Mexican scientists was widely believed to be not the best for the job.
Treatment with dovitinib demonstrated modest efficacy in patients with advanced SCC with FGFR1 amplification, suggesting that gene amplification may not be the appropriate biomarker for FGFR inhibitor response.
Gene amplification of MELK occurs in both primary tumors and human breast cancer cell lines, especially in ER - negative samples (Figure 3 — figure supplement 1).