Sentences with phrase «gene analysis technologies»

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In the case of CHD2, scientists collaborating with the EuroEPINOMICS RES consortium used antisense technology to rapidly generate zebrafish larvae with a partial loss of function of this gene, and were then able to detect epileptic seizures in these animals using electrographic analysis (this method is very similar to electroencephalography, or EEG, which is used to analyze seizures in humans).
«Our attempts to determine the causes behind the disorder were greatly aided by gene sequencing technology and biocomputational analysis,» adds Dr. Knierim.
He has worked in the biotech industry as a research scientist for over 11 years with a focus on emerging technologies including gene targeting in mice, molecular analysis of transgenes using GFP variants at the single cell level, and developing flow cytometry reagent kits to speed up assay development time for researchers.
To this purpose, GenProfile utilizes a powerful technology platform, which involves proprietary high - throughput technologies for gene sequence comparison (e.g., multiplex sequence comparison), genotyping (MALDI - TOF minisequencing), unique approaches to data analysis and interpretation, as well as a large network of clinical collaborators.
The analysis was sheer drudgery at first, but as DNA technology improved, reading history from genes became automatic.
Our goal is to help scientists who want to use this technology for gene editing by summarizing current advances on many technical aspects, from the RNA guide optimized design to the genotyping analysis and the validation of the newly generated models.
Topics for the scientific sessions are: Single cell genomics and gene expression Genetic interactions RNAi and somatic cell genetics Protein - DNA interactions Cancer The meeting also highlights existing opportunities for academic and industrial researchers to access automated cell - based and biochemical technologies based at the Karolinska High Throughput Center; home to one of the most sophisticated, state - of - the - art, ultra-high performance liquid handling and analysis platforms in Europe.
Dr. Sonntag studies this concept on the molecular and cellular level using a translational research approach that integrates the analysis of human material, such as postmortem brains, primary cell systems, and neural cell populations generated from patients» - or healthy individuals» - derived induced pluripotent stem cells (iPSC), or induced neurons (iNs), in combination with molecular, biochemistry, and lentivirus - mediated gene - engineering technologies.
next - generation DNA sequencing and gene and protein array platforms, which allow researchers to perform more comprehensive molecular analyses of tumors, more quickly and accurately, than was possible with older technology
Genetic Engineering and Model Validation: engineering and generation of customised genetically modified mouse models, generation of genetically modified ES cells, genotyping, analysis of gene expression, model validation by molecular analysis, CRISPR / Cas9 nucleases technology
Using genetic and epigenetic analyses coupled with powerful perturbation technologies to test gene functions in human cells and mouse models, we hope to identify the critical drivers of this disease and the basis for therapeutic responses.
In the past few years, FANTOM researchers have applied Cap Analysis Gene Expression (CAGE), a genomic technology developed at RIKEN, to numerous mammalian cell and tissue types.
Other often utilized technologies are fluorescence activated cell sorting, tissue culture, gene expression analysis, protein analysis, and lentiviral mediated gene transfer.
In addition, the section will entertain submission of work addressing all aspects of post-transcriptional gene silencing, technologies related to microRNA analyses, as well as bioinformatics relevant to microRNA research.
Because genes influence nearly all biological phenomena, this technology is impacting the analysis in fields as diverse as cancer, immunology, neurobiology, human genetic disorders, endocrinology, and neurobiology.
The methods can be readily adapted for high - throughput analysis of gene expression in any tissue or model organism, and they may also be expanded to accommodate complementary technologies such as immunohistochemistry, mass spectrometry, or other imaging modalities.
«Low - Calorie Diet Slows Aging in Mice in Study,» claimed a recent headline.17 According to the article, «Putting elderly mice on a very low - calorie diet for as little as four weeks reversed many of the changes in the activity of various genes that had occurred during normal aging...» The resesearchers were not looking at actual signs of disease, nor were they measuring lifespan, but instead focused on the analysis of 11,000 different genes using a method called microarray technology in which Spindler has large financial holdings.
Before the new technology, gene analysis was done one gene at a time, making it time - consuming and tedious.
He is using a new microarray analysis technology that assesses more then 23,000 genes.
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