Not exact matches
In the case of CHD2, scientists collaborating with the EuroEPINOMICS RES consortium used antisense
technology to rapidly generate zebrafish larvae with a partial loss of function of this
gene, and were then able to detect epileptic seizures in these animals using electrographic
analysis (this method is very similar to electroencephalography, or EEG, which is used to analyze seizures in humans).
«Our attempts to determine the causes behind the disorder were greatly aided by
gene sequencing
technology and biocomputational
analysis,» adds Dr. Knierim.
He has worked in the biotech industry as a research scientist for over 11 years with a focus on emerging
technologies including
gene targeting in mice, molecular
analysis of transgenes using GFP variants at the single cell level, and developing flow cytometry reagent kits to speed up assay development time for researchers.
To this purpose, GenProfile utilizes a powerful
technology platform, which involves proprietary high - throughput
technologies for
gene sequence comparison (e.g., multiplex sequence comparison), genotyping (MALDI - TOF minisequencing), unique approaches to data
analysis and interpretation, as well as a large network of clinical collaborators.
The
analysis was sheer drudgery at first, but as DNA
technology improved, reading history from
genes became automatic.
Our goal is to help scientists who want to use this
technology for
gene editing by summarizing current advances on many technical aspects, from the RNA guide optimized design to the genotyping
analysis and the validation of the newly generated models.
Topics for the scientific sessions are: Single cell genomics and
gene expression Genetic interactions RNAi and somatic cell genetics Protein - DNA interactions Cancer The meeting also highlights existing opportunities for academic and industrial researchers to access automated cell - based and biochemical
technologies based at the Karolinska High Throughput Center; home to one of the most sophisticated, state - of - the - art, ultra-high performance liquid handling and
analysis platforms in Europe.
Dr. Sonntag studies this concept on the molecular and cellular level using a translational research approach that integrates the
analysis of human material, such as postmortem brains, primary cell systems, and neural cell populations generated from patients» - or healthy individuals» - derived induced pluripotent stem cells (iPSC), or induced neurons (iNs), in combination with molecular, biochemistry, and lentivirus - mediated
gene - engineering
technologies.
next - generation DNA sequencing and
gene and protein array platforms, which allow researchers to perform more comprehensive molecular
analyses of tumors, more quickly and accurately, than was possible with older
technology
Genetic Engineering and Model Validation: engineering and generation of customised genetically modified mouse models, generation of genetically modified ES cells, genotyping,
analysis of
gene expression, model validation by molecular
analysis, CRISPR / Cas9 nucleases
technology
Using genetic and epigenetic
analyses coupled with powerful perturbation
technologies to test
gene functions in human cells and mouse models, we hope to identify the critical drivers of this disease and the basis for therapeutic responses.
In the past few years, FANTOM researchers have applied Cap
Analysis Gene Expression (CAGE), a genomic
technology developed at RIKEN, to numerous mammalian cell and tissue types.
Other often utilized
technologies are fluorescence activated cell sorting, tissue culture,
gene expression
analysis, protein
analysis, and lentiviral mediated
gene transfer.
In addition, the section will entertain submission of work addressing all aspects of post-transcriptional
gene silencing,
technologies related to microRNA
analyses, as well as bioinformatics relevant to microRNA research.
Because
genes influence nearly all biological phenomena, this
technology is impacting the
analysis in fields as diverse as cancer, immunology, neurobiology, human genetic disorders, endocrinology, and neurobiology.
The methods can be readily adapted for high - throughput
analysis of
gene expression in any tissue or model organism, and they may also be expanded to accommodate complementary
technologies such as immunohistochemistry, mass spectrometry, or other imaging modalities.
«Low - Calorie Diet Slows Aging in Mice in Study,» claimed a recent headline.17 According to the article, «Putting elderly mice on a very low - calorie diet for as little as four weeks reversed many of the changes in the activity of various
genes that had occurred during normal aging...» The resesearchers were not looking at actual signs of disease, nor were they measuring lifespan, but instead focused on the
analysis of 11,000 different
genes using a method called microarray
technology in which Spindler has large financial holdings.
Before the new
technology,
gene analysis was done one
gene at a time, making it time - consuming and tedious.
He is using a new microarray
analysis technology that assesses more then 23,000
genes.
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