The similarity of the mouse and human genetic make - up means that
genes associated with disease in humans can be studied and further investigated in mouse models.
Purpose: Many current studies are aimed at trying to
identify genes associated with diseases in dogs, but we are looking to see if there might exist «protective genes» that could help protect against these same life - limiting diseases in the dog.
«The research findings do not have immediate implications for treatment, but the hope is that
discovering genes associated with disease risks will bring scientists closer to biological pathways and may suggest useful targets for new treatments,» said geneticist Brendan J. Keating, DPhil, one of co-senior authors of the paper, of The Center for Applied Genomics at The Children's Hospital of Philadelphia and faculty at the Department of Pediatrics at the University of Pennsylvania.
Many of the regulatory genes that contribute to lupus and other autoimmune disorders did not interact with EBNA2, and some individuals with activated regulatory
genes associated with disease risk do not develop disease.
Conversely, fundamental research using mouse models can
identify genes associated with disease and provide insights into pathogenic mechanisms underlying environment - driven diseases, including infectious diseases and cancer.
The largest - ever study to sequence the whole genomes of breast cancers has uncovered five
new genes associated with the disease and 13 new mutational signatures that influence tumour development.
These products are designed to alter the expression of target genes in the body, suppressing expression
of genes associated with disease, or restoring expression of genes required for health.
About two years ago, funding from the «Ice Bucket Challenge» — the viral video trend that raised millions for ALS research and was initially met with a big dollop of skepticism — helped researchers identify
a gene associated with the disease.
In 2015, the viral «Ice Bucket Challenge» helped fund groundbreaking research that led to the discovery of
a gene associated with the disease.
Having
a gene associated with a disease is an indicator only that you might get that disease.
During her neurology residency at the University of Missouri, she was fortunate enough to work with the researchers who discovered
the gene associated with this disease which will aid in the diagnosis of degenerative myelopathy.