Sentences with phrase «gene candidates»

Then, they estimated enrichment factors by determining how frequently those known cancer - associated genes occurred among the top gene candidates identified by different analysis methods.

She is scanning the genomes of individuals in the current study to identify regions that may contain additional gene candidates.

36) Gao K, Lockwood WW, Li J, Lam WL, Li G (2008) Genomic analyses identify gene candidates for acquired irinotecan resistance in melanoma cells.

Dr. Beth Shapiro, head of the UCSC Paleogenomics Lab continues: «We provide the most extensive list of gene candidates that have been favored by humans following the domestication of horses.

These summaries have a wide range of applications such as the prediction of disease gene candidates, drug repurposing, and many more.

Recovery of ancient DNA, coupled with low - throughput gene candidate analyses, has previously been used to investigate changes in the genetic diversity of horses over time.

«There has to be a functional way of assessing the role of these cancer - gene candidates as they appear in sequencing studies,» Sanchez - Rivera says.

These genes include synaptojanin 2 (SYNJ2), which has been detected with PAML [phylogenetic analysis by maximum likelihood; false discovery rate (FDR) = 5 %] and represents a longevity gene candidate associated with variation in levels of agreeableness and cognitive abilities (60, 61).

«Although it could be a coincidence, the fact that knocking out the gene produces a lupus - like disorder makes the Ro gene a candidate causative gene that is certainly worth looking at in patients,» said Wolin.

Some of the identified genes are previously known to be involved in the development of oyster shells, but the study also presents novel gene candidates.

By sequencing the exomes of multiple individuals, isolating what we'd call «tier 1» variants — Nonsynonymous, nonsense, splice site, or frameshift - indel — and then removing all known common variants from public databases, Dr. Shendure and colleagues can reduce 20,000 gene candidates down to a handful.

But by the late nineties, DRD4 was a leading gene candidate for ADHD.

The increased power provided by looking for specific gene candidate variations rather than linked markers will aid the identification of epilepsy risk factors, perhaps leading to development of DNA tests to enable breeders to select against such risk factors.

McCallion's strategy to make sense of all this data looks at the active genes in cells affected by a disease, groups of genes that interact with one another, their vulnerability to mutation and information from past scientific studies to filter more than a thousand gene candidates for disease risk down to just a handful within any one implicated region.

We have some gene candidates for the next step of the pathway, and we are just starting to characterize those.»

In 2013, Soderling's group selected one of those gene candidates, Arp2 / 3, based on its importance in controlling the formation of synapses — the links between neurons — and its association with multiple neuropsychiatric disorders.