Supported - Consistency with RNA - seq and / or protein /
gene characterization data, in combination with similar staining pattern if independent antibodies are available.
A reliability score is set for all genes and indicates the level of reliability of the analyzed protein expression pattern based on available protein / RNA /
gene characterization data.
Uncertain - Inconsistency with, or lack of, RNA - seq and / or protein /
gene characterization data, in combination with dissimilar staining pattern if independent antibodies are available.
In the first step, stainings in different cell lines with the same antibody are reviewed and the results are compared with available protein /
gene characterization data for subcellular location.
Approved - Consistency with RNA - seq data in combination with inconsistency with, or lack of, protein /
gene characterization data.
A reliability score is set manually for all genes and indicates the level of reliability of the analyzed protein expression pattern based on available protein / RNA /
gene characterization data from both HPA and the UniProtKB / Swiss - Prot database.
Not exact matches
Research areas include species for comparative research; phenotypic
characterization; fitness, genome stability and lateral
gene transfer; control of organismal traits; monitoring and surveillance; modeling and standardization of methods and
data.
Monitoring these expression ratios in live cells would provide prospective
gene expression
data as opposed to traditional retrospective
characterization.
Large - scale functional genomics
data often fail to connect to standard experimental approaches of
gene characterization in individual laboratories.
Much of the research carried out today on rodent models generates high resolution image
data, allowing
characterization and analysis of brain molecular distribution,
gene expression, and connectivity.
The primary focus of the proposed session will be on clinical
characterization,
data generation, analysis and results, including implications for the specific diseases and traits, for
gene discovery and for biologic and clinical utility.