Two new
gene clusters involved in the degradation of plant cell wall from the fecal microbiota of Tunisian dromedary — Rihab Ameri — PLoS One
Two new
gene clusters involved in the degradation of plant cell wall from the fecal microbiota of Tunisian dromedary
Not exact matches
The cap ends up close to a
cluster of
genes on the surrounding DNA that are
involved in learning and which became more active during learning tasks.
Clusters of
genes that became less active were those
involved in chronic inflammation, which can lead to high blood pressure and heart disease.
Killary and colleagues earlier identified a
cluster of
genes involved in cancer migration and then analyzed the proteins produced by those
genes.
The new locus they have identified is near a
cluster of
genes which code for proteins called «glycophorins» that are
involved in the malaria parasite's invasion of red blood cells.
«The most intriguing of these
genes is FGFRL1, which has a
cluster of amino acid substitutions unique to giraffe that are located in the part of the protein that binds fibroblast growth factors — a family of regulators
involved in regulating many processes including embryo development,» Cavener said.
Most analytical approaches to this problem are rather rudimentary and
involve calculating simple correlations among the
genes whose expression changes in response to a perturbation,
clustering the
genes by molecular or known functional class, and drawing crude inferences about mechanism on that basis.
Upregulated
genes clustered into at least 7 functional groups, including immediate early
genes or transcription factors, cell - cycle related
genes, stress - responsive protein
genes, cell signaling protein
genes, cell adhesion and cell surface protein
genes,
genes involved in translation and protein turnover, and
genes encoding metabolic proteins.
Another interesting local network structure is centered around CLU, a
gene shown to be
involved in AD based on genome - wide association studies, with
genes in the integrin family,
involved in cell adhesion,
clustered around CLU.
Mutations in
genes involved in iron - sulfur
cluster synthesis generally have normal sized red blood cells (normocytic) and may be syndromic or non-syndromic.
For example,
clusters containing
genes that are upregulated during the course of ES cell differentiation (Table 3) include in order of time of expression:
cluster 30 that represents
genes which take part in the formation of the three embryonic germ layers during gastrulation, i.e., Goosecoid, Cerberus like 1 homolog, Wnt3, Mesp1, Mixl1, mEomes and Even - skipped 1;
cluster 15 containing molecular regulators of early mesoderm development including Bmp2, Bmp5, Msx1, Msx2, Cripto, Tbx20, Hey2, Smad6, Vegfr2 (Kdr), Foxf1 and Hand1;
cluster 20, which comprises regulatory and structural
genes linked to hemopoiesis such as Gata1, Nfe2, Klf1, Tie1, hemoglobins (Hba - x, Hbb - b1) and Glycophorin A;
cluster 12, which is rich in
genes involved in cardiac development, e.g., Mef2c, Myl4, cardiac Troponin T2, Tropomodulin 1, myosin binding protein C, Bves, Angiopoietin 1 and Angiopoietin 2; and,
cluster 4, which consists mostly of
genes associated with neuronal development and differentiation, for example, Neurog1, Neurog2, Olig2, Nkx6.1, Neurod4, Pou3f2, Pou3f4, Cacna2d3, Cacng4, Kcnq2 and EphA5.