An analysis of all gene transcription in the cultured cell lines turned up a large
gene complex in which gene expression differed conspicuously in cells from patients compared to controls.
Ho - mo - logous or - gans are now known to be produced by totally different
gene complexes in the different species.
Not exact matches
«The interaction of
genes, environment and nurture come together
in complex ways to produce the variety of human behavior.»
Gene genealogies and AFLP analyses
in the Fusarium oxysporum
complex identify monophyletic and nonmonophyletic formae speciales causing wilt and rot disease.
And
in any case «the
gene» is a purely analytic sub unit of the greater and more significant
complex that is the genetic code along the chromosomes of any organism.
People of every nation, color, language, belief, and condition are now known to possess
in their body cells trait factors drawn by an inconceivably
complex sequence of intercombinations from a common «
gene pool.»
And like Evolution, the Theory of Mechanics has been supplanted by more
complex and more accurate theories (
in the case of Mechanics, both Quantum Mechanics and Relativity have arisen to deal with its flaws;
in the case of Evolution, the technical theories - such as
gene borrowing and virus - guided genetic drift - do not have catchy names).
Yes, this amazing bio-chemical-electro
complex being with all the blueprints
in the
genes just popped into existence because, because because... it's magic!!!!!!!! Fairy Dust!!!!!!! Primordial Fairy Dust... yes a good name helps....
Actually, science is continually showing us that while no one
gene is defined as being responsible for a man or woman being attracted to their own gender, the
complex reasoning behind it, much like many other parts of being a human being, is
in fact based
in genetics,
in the physical.
In this episode of the Birthful podcast, I talk with professor
Gene Declercq about the
complex realm of inductions.
These experiments were complemented by genetic manipulations
in which some mice were engineered to lack a
gene known as Tap1, which is crucial for the MHC I
complex to make its way to the cell surface.
«What we found is that on a molecular level, the
complex I deficit is probably just the tip of the iceberg of a pervasive deficit
in all energy
genes.»
Standard approaches also struggle to find combinations of multiple
genes that affect disease risk
in complex ways (known as genetic interactions).
«Many diseases, especially
complex diseases, involve multiple
genes, and this system could be used therapeutically to target and activate multiple
genes together and rescue these disease phenotypes,» says Albert Cheng, a graduate student
in the Jaenisch lab and co-author of the Cell Research paper.
Expression of a microinjected porcine class I major histocompatibility
complex gene in transgenic mice
Complex traits like the ones
in the study are each influenced by many different
genes, while at the same time, several different traits can be affected by the same
genes.
Individual body odor is influenced by
genes, and by one group
in particular: the
genes that determine which proteins combine to form your unique major histocompatibility
complex (MHC).
«As you look for methods to discern
complex immune responses
in human cells, more and more people look at what
genes are turned on with infections or vaccination procedures.»
Scientists have shifted from studying single molecules to investigating large
complexes of interacting biological macromolecules involved
in processes such as metabolic pathways,
gene expression, and development of disease.
Snake venoms are
complex protein mixtures encoded by several
gene families and these proteins function synergistically to cause rapid paralysis or death
in prey.
The Cambrian explosion looks abrupt
in the fossil record, but the surprising message from evo devo is that all the
genes for building big,
complex animal bodies long predated the appearance of those bodies.
Yet of maybe even greater
gene - spreading significance is the ability to tell differences
in MHC — the major histocompatibility
complex, a
gene family linked to the immune system and body scent.
Host
genes of the major histocompatibility
complex (the
genes that determine how mammals respond to pathogens) play a significant role
in how the immune system responds to all pathogens.
The nonredundant protein sets of flies and worms are similar
in size and are only twice that of yeast, but different
gene families are expanded
in each genome, and the multidomain proteins and signaling pathways of the fly and worm are far more
complex than those of yeast.
Citing a wealth of recent research that explores the ways
genes work together to produce complex biological processes, Itai Yanai and Martin Lercher argue that it is time to embrace a new, more holistic, metaphor in their book, The Society of G
genes work together to produce
complex biological processes, Itai Yanai and Martin Lercher argue that it is time to embrace a new, more holistic, metaphor
in their book, The Society of
GenesGenes.
«Same switches program taste, smell
in fruit flies: Findings help explain how
complex nervous systems arise from few
genes.»
A
complex relationship between
genes, hormones and social factors can lead to eating disorders
in women.
With rapid advances over the past 10 years
in technologies for discovering and analyzing the functions of
genes, researchers are now increasingly able to get at the biological roots of
complex disorders such as substance abuse and addiction.
«
Gene sequencing has opened a huge door to how
complex these communities are,» says Patrick Seed, a Duke pediatrician specializing
in infectious disease, who with biologist Rob Jackson is a lead investigator of the premature infant study.
However, it was not clear whether changes
in lncRNA
genes could put people at risk of developing
complex diseases
in the same way that changes
in protein - coding
genes do.
To test that idea
in the ragworm, Tomer used a technique he had developed to examine the
complex brains of small creatures with unprecedented clarity: He created a high - resolution map of the worm's brain cells according to the
genes they express, not just their shape and location.
Long before anyone told you to drink milk to make your teeth strong, a
complex system of
genes made sure your molars ended up
in the back of your mouth and your sharp incisors
in front.
For example, the genus Corticium also uses the
gene DMRT1 for sex determination; this
gene was thought to be present only
in more
complex metazoans (reptiles, birds, mammals, etc.).
Although it has always been believed that sponges are so simple than their responses to stimuli are minimal, the study identifies some
genes involved
in nerve conduction
in more
complex animals: «This proves that sponges» responses to environmental changes or physical stimuli may be more
complex than it was thought,» underlines Ana Riesgo, who also participates
in the project Actiquim, focused on chemical ecology
in Antarctica.
How it hides:
In a normal cell,
genes encode instructions for surface proteins known as the major histocompatibility
complex (MHC).
The study identifies a wide set of
genes — previously associated with
complex structures
in higher animals — which were supposedly absent
in sponges.
According to a study published on the journal Molecular Biology and Evolution, most
genes involved
in complex processes are present
in sponges.
To understand the
complex relationship among the miRNA let - 7, the KRAS
gene and the KRAS protein, Slack decided to look at how they interacted
in lung cancer.
Nearly all
genes identified
in sponges have more
complex functions
in metazoans.
They achieved this by transiently disturbing interactions between target
genes and PcG proteins, which are
complexes involved
in the repression of several
genes governing development.
In Class I engagement, Sox9 binds to the genome indirectly via the basal transcriptional
complex, regulating transcription of
genes for basal cell activities.
Research coordinated by Osaka University has now shown that the nuclear protein
complex cohesin must be expressed at sufficient levels
in the early mouse brain to control
gene regulation and allow development of healthy neuronal networks and behavioral characteristics.
James Collins, a professor of biomedical engineering at Boston University who was not associated with this research, says, «Efforts
in synthetic biology to create
complex gene circuits are often hindered by unanticipated or uncharacterized interactions between submodules of the circuits.
«Single - nucleus RNA sequencing, droplet by droplet: DroNc - Seq, technology that merges single - nucleus RNA sequencing with microfluidics, brings new scale to
gene expression studies
in complex tissues.»
The fact that so many proteins interact with the 26 bait proteins indicates that these original proteins play key roles
in a
complex process that wasn't apparent on the level of the «suspect»
genes.
Living cells express
genes involved
in physiological functions like development and metabolism via
complex mechanisms.
The study was inspired
in part by the
complex effects of a new melanoma drug developed by the biotech companies Plexxikon and Roche that blocks a protein made by a mutated
gene called BRAF.
Disease processes often begin with mutations
in the transcription factor, or
in the DNA they bind to inside the nucleus of cells to regulate the
complex interplay of
genes needed for a healthy functioning body.
Dysfunction
in dopamine signaling profoundly changes the activity level of about 2,000
genes in the brain's prefrontal cortex and may be an underlying cause of certain
complex neuropsychiatric disorders, such as schizophrenia, according to UC Irvine scientists.
True blue pigment remained elusive, scientists thought, because its origin was
complex; multiple
genes have been shown to be involved
in its generation.