Sentences with phrase «gene control mechanism»

In a study described in the January 28 issue of Nature Neuroscience, the Hopkins team describes this new gene control mechanism and how it may contribute to Rett Syndrome, a nervous system disorder affecting mostly girls that causes problems with movement and communication.

Dr. Saptarsi Haldar's research focuses on how cells in the cardiovascular system control gene expression and how these gene control mechanisms go awry during disease.

Not exact matches

For my dissertation, I studied the fundamental mechanisms that control gene activity in plants.

DNA methylation is a mechanism cells use to control gene expression at the epigenetic level.

The proposed strategy reflects a continuing move toward combination therapies, particularly when it comes to epigenetic approaches, which target the mechanisms that control whether genes are switched «on» or «off.»

Dr Kappei said, «We are now actively pursuing the exact molecular mechanism through which ZBTB48 controls telomere length, and further looking into ZBTB48's role in various cancers, such as neuroblastoma, in which the gene is frequently deleted.

«The fact that the genetic code can simultaneously write two kinds of information means that many DNA changes that appear to alter protein sequences may actually cause disease by disrupting gene control programs or even both mechanisms simultaneously,» said Stamatoyannopoulos.

But some of the most powerful forms of gene drives are hard to control or reverse, and without the proper biosecurity mechanisms they could theoretically spread beyond the target population to impact an entire species.

DNA methylation, one mechanism of epigenetics, is a chemical tag on DNA that does not change the gene sequence but is involved in controlling gene expression.

DNA methylation is an epigenetic mechanism used by cells to control gene expression.

But as you said, as an individual eats a high - fat diet or is exposed to other types of environmental exposures, the ability of the liver to adapt involves turning on and turning off certain liver genes to control the liver's activity, and that's mediated through these epigenetic mechanisms that modify the activity of established liver genes.

Now, Shannon Xu, together with Gantz and Bier, employ CRISPR / Cas9 to edit gene regulatory elements in their native genomic environments, revealing new fundamental mechanisms that control gene activity, as described Feb. 6 in eLife.

Molecular recognition is fundamental to transcriptional regulation, the primary mechanism by which cells control gene expression.

Each cell of our body is the result of an orchestra of sophisticated mechanisms that control which genes are and are not expressed at any given time.

HSF1 controls other genes besides those for HSPs, so researchers now need to pin down which molecular mechanisms the protein enlists to help cancer cells beat stress, says Calderwood.

«Our findings suggest this is because part of the biological mechanism behind the damage is affected by a person's circadian clock and the underlying genes that control it.»

Though this study doesn't yet identify the mechanism that controls gene activity for generations after a famine, the findings build a foundation to do so, Baugh said.

[The intracellular domain's function of] transcribing a gene into a protein that then performs some function within the cell generally takes about two hours, but we were seeing leakage within 30 minutes of blocking Notch1, further suggesting that whatever process controls the permeability of the barrier is operating via a completely different mechanism,» says Bill Polacheck, Ph.D., Postdoctoral Fellow at the Wyss Institute and co-first author of the paper.

The authors uncover the cellular and molecular mechanisms, as well as the gene network regulated by Sox9 during the early steps of skin tumor initiation and demonstrates that Sox9 controls the long term maintenance and expansion of oncogene expressing cells by promoting self - renewing division and inhibiting differentiation.

University of Alabama at Birmingham researchers show, for the first time, that the well - known mechanism of gene expression control — dynamic changes in DNA methylation — is also involved in changes to the excitability of neural cells.

The Center for RNA Research at the Institute for Basic Science has succeeded in revealing, for the first time, the mechanism of how miRNAs, which control gene expression, are regulated in the early embryonic stage.

Through this mechanism, histones control the ability of PARP1 to activate genes and repair DNA damage.

In addition to reevaluating how histones control gene activation, the study also reports a new mechanism of PARP1 regulation.

The team of Luis Lopez - Molina, professor at the Department of Botany and Plant Biology of UNIGE's Faculty of Science, Switzerland, has been interested for a long time in the mechanisms controlling germination, arguably the most critical decision in the life of a plant: «We have discovered that the genes involved in the synthesis of cutin, a waterproof substance, are important for the maintenance of dormancy in seeds of Arabidopsis thaliana, a small plant widely used as a model organism to study plant biology.

A new study in fat cells has revealed a molecular mechanism that controls how lifestyle choices and the external environment affect gene expression.

Researchers from the University of Geneva (UNIGE) and the Ecole polytechnique fédérale de Lausanne (EPFL), Switzerland, are studying the mechanisms controlling nucleosome dynamics and how this affects gene expression.

One is straightforward — during development, cells are assuming their identities and need precise control over protein production, so cells lacking a gene expression regulation mechanism are bound to have defects, particularly in the case of specialized cells like neurons.

Adrian R. Krainer Posttranscriptional control of gene expression; pre-mRNA splicing mechanisms, fidelity and genetic diseases; alternative splicing; RNA - protein interactions; cancer

Synthetic RNA - protein modules integrated with native translation mechanisms to control gene expression in malaria parasites.

Using data from blood and brain tissue, a team led by researchers at Johns Hopkins Bloomberg School of Public Health found that they could gain insights into mechanisms that might help explain autism by analyzing the interplay between genes and chemical tags that control whether genes are used to make a protein, called epigenetic marks.

More specifically, he has developed therapeutic approaches that target gene - control mechanisms in the stressed and failing heart, a process that has striking similarities to uncontrolled growth in cancers.

disruption of the mechanisms that control the activation levels of different genes, leading to genes being wrongly activated or inactivated

In addition, A-to-I RNA editing is involved in control of the expression and function of microRNA (miRNA), which is a small RNA essential for the RNAi mediated gene silencing mechanism.

University of Lisbon: Professor Margarida Gama Carvalho («Characterization of post-transcriptional control mechanisms regulating SMN2 gene expression.»)

Major Symposium A: Transcriptional Control of Immunity: Diverse Regulatory Mechanisms in Gene Regulation Chairs: Amy S. Weinmann, Univ. of Alabama, Birmingham Boris Reizis, New York Univ..

Another aspect of the controlled process is the molecular mechanism which is estimated to include genes in several molecular pathways which aid the skeletogenesis.

Studying coral calcification with antagonists can provide further information and knowledge to better understand the role and function of genes that participate in the cellular control mechanism, and in the coral organic matrix.

His group is are studying the mechanism of stable inherited epigenetic transcriptional repression by Polycomb - group (Pc - G) protein complexes, and the effects of deregulation of Pc - G genes on Homeobox gene expression, development, Cell cycle control and cancer formation.

Homeostatic control of synaptic function has been demonstrated in diverse organisms, including flies, rodents, and humans, yet the genes and molecular mechanisms governing these processes remain unclear.

The gene and associated mechanism of quality control appears to be conserved in mammals, but there is as yet little further research leading towards trying a similar approach in mice and humans to see what happens.

In addition, we address the regulatory mechanisms of gene expression and the control mechanisms of DNA replication.

They identified genetic mechanism controlling this process in all three — a common set of miRNA - regulated genes that diverged on the evolutionary tree aproximately 420 million years ago.

Researchers have identified a host of factors involved in epigenetic control of gene expression and development, but many of the precise mechanisms underlying this type of regulation remain unclear.

In the meantime, Baojin Yao, postdoctoral fellow, focused on identifying mechanisms controlling the expression of the SOX9 gene in chondrocytes (Yao et al., Nucleic Acids Res., 2015).

There is, however, another mechanism by which ARE - regulated genes are controlled and that is through Bach1, a transcriptional repressor that binds to ARE promoter elements resulting in suppression of Nrf2 activity.

These studies will investigate the consequences of ApoF knockdown on cholesterol disposition in an animal model, quantify ApoF levels in human subjects and identify lipoprotein properties that cause ApoF to bind and subsequently inhibit cholesteryl ester transfer protein activity, and investigate the molecular mechanisms controlling ApoF gene expression.

This text covers topics ranging from plant genome structure and the key control points in how genes are expressed, to the mechanisms by which proteins are generated and how their activities are controlled and altered by posttranslational modifications.

New research led by the University of Bristol has found that genes in the brain that play a crucial role in behavioural adaptation to stressful challenges are controlled by epigenetic mechanisms.

The understanding of the molecular pathways the gene control is crucial to the understanding of the mechanisms of pathogenesis, the discovery of new targets and preclinical human therapeutic applications.

This is in accordance with previous reports that decitabine and 5 - azacytidine produce a marked synergistic effect in combination with suberoylanilide hydroxamic acid and romidepsin in T - lymphoma cell lines by modulating cell cycle arrest and apoptosis.26, 27 As a mechanism of action, KMT2D mutations of B - lymphoma cells promote malignant outgrowth by perturbing methylation of H3K4 that affect the JAK - STAT, Toll - like receptor, or B - cell receptor pathway.28, 29 Here our study indicated that dual treatment with chidamide and decitabine enhanced the interaction of KMT2D with the transcription factor PU.1, thereby inactivating the H3K4me - associated signaling pathway MAPK, which is constitutively activated in T - cell lymphoma.13, 30,31 The transcription factor PU.1 is involved in the development of all hematopoietic lineages32 and regulates lymphoid cell growth and transformation.33 Aberrant PU.1 expression promotes acute myeloid leukemia and is related to the pathogenesis of multiple myeloma via the MAPK pathway.34, 35 On the other hand, PU.1 is also shown to interact with chromatin remodeler and DNA methyltransferease to control hematopoiesis and suppress leukemia.36 Our data thus suggested that the combined action of chidamide and decitabine may interfere with the differentiation and / or viability of PTCL - NOS through a PU.1 - dependent gene expression program.