Sentences with phrase «gene copies found»

Not exact matches

Also found in the water bear genome were more copies of an anti-oxidant enzyme and a DNA repair gene than in any other animal.

A previous study found that today's dogs have many copies of the AMY2B gene, which produces an enzyme that helps break down starch, while wolves have only two copies.

So Sandra Ryeom at the Children's Hospital in Boston and colleagues bred mice with three genes to find out if an extra copy gave them extra protection against cancer.

The less adept mice, Rubin's team found, carry extra copies of a previously known human gene called DYRK; a mutated version of an almost identical gene in fruit flies, called minibrain, causes neurological defects.

The investigators found that people with only one working copy of the gene had LDL cholesterol levels an average of 12 milligrams per deciliter lower than the wider population of people with two working copies of the gene.

The findings jibe with previous reports that PCR tests sometimes overlook a gene with large deletions, detecting only the other, normal copy of the gene.

They found that when the gene was on the leading strand, the polymerase gaffed the copying up to 6 times more often than when the gene was on the lagging strand.

Researchers found that some people who had been repeatedly exposed to HIV but remained uninfected had two copies of a defective CCR5 gene.

The two studies together suggest that single copies of inactivating ANGPTL3 mutations are found in roughly one of every 250 people of European descent, whereas people with mutations in both copies of the gene — as in the family studied by Musunuru and colleagues — are much rarer.

Affected family members, the group found, had inherited one or two defective copies of ZIC3, a previously unknown gene that appears to code for a transcription factor — a protein that switches other genes on or off.

She harbors two mutant copies of a gene, and therefore lacks a protein that manages blood clotting, but researchers found that people with one inactivated gene copy outlive their peers by a decade and gain protection against diabetes.

The population study findings, including those from the JACC study, suggest that even the partial inactivation of ANGPTL3 — carriers typically have one mutant copy of the gene and one working copy — may be powerfully protective against coronary artery disease, which has long been one of the leading causes of death in developed countries.

By comparing the genetic sequences of the mutant and normal flies, the researchers found that the forgetful flies had an inactive copy of a gene that he and his Chilean collaborators dubbed Volado (Vol)-- South American slang for absentminded.

To find out, the scientists bred mice that lacked either one or both copies of the gene.

What the researchers found especially astonishing is that this was true even in octogenarians with two copies of the APOE - 4 gene, which is present in about 90 percent of 80 - year - olds with Alzheimer's.

What emerged from their work was the finding that the girl had inherited two differently mutated copies of the gene IRF7, which encodes a protein that amplifies the production of interferon, a critical part of the body's response to viral infections.

The finding also led them to the protein made by a normal copy of the gene that promotes sleep early in the night and properly regulates sleep cycles.

«What you have to do,» he explains, «is find a gene that has only one copy expressed.»

Over a five - to 10 - year period, the disease progressed 14 percent faster in people with one copy of APOE4 and 23 percent faster in people with two copies than in people who didn't have that version of the gene, the researchers found.

By comparing proteomic and RNA - sequencing data from people on different exercise programs, the researchers found evidence that exercise encourages the cell to make more RNA copies of genes coding for mitochondrial proteins and proteins responsible for muscle growth.

In a remote Turkish village, researchers have located a family with a mutation in the leptin gene similar to the one found in lab mice, and — just like the mice — adults with two copies of the mutation are grossly overweight and don't ever go through puberty.

Researchers found that kochia has evolved to have multiple copies of a gene code that targets glyphosate.

When the team analyzed the patient's DNA, they found a mutation in both copies of the leptin gene.

For instance, the researchers found that an immune system gene called DUSP22A on chromosome 6 was duplicated, but its copy, DUSP22B, is located on chromosome 16.

They frequently find that in both types of disease the region of the «healthy» copy of chromosome 17 that should carry the normal copy of the BRCA1 gene is missing, leaving only one copy of the gene — the one with the cancer - causing mutation.

The researchers emphasized that the finding does not suggest that breast milk from mothers without an active copy of the gene is less nourishing or healthy.

It is found in about 1 in 2,000 people, and occurs when an individual inherits a defective gene copy from both parents.

The study found that, on average, Bifidobacterium were established earlier and more frequently in infants fed by women with an active copy of the gene, the secretors, than without one, the non-secretors.

The team therefore analyzed the case history of 890 breast cancer patients and found that low Numb - 1 and -2 levels correlated with an increased risk of aggressive, metastatic disease, particularly for the luminal subtype of breast cancers, which tend to retain a normal, functional copy of the p53 gene.

The kitten was found to have two copies of a mutation in the NPC1 gene, which causes Niemman - Pick type 1, a fatal disorder.

A yeast retrotransposon called Ty3, the researchers have found, is especially judicious: it always inserts itself in safe places, outside genes rather than inside them, and only near genes of which a yeast cell has many copies.

They found that the number of copies of lncRNA genes on a chromosome consistently change in 12 different cancer types and lncRNA genes are widely expressed in cancer cells.

The team found that adding in a single extra copy of gene that expresses Maf1 decreased stored lipids by 34 percent, while reducing Maf1 levels increased stored lipids by 94 percent.

Results from the analysis confirmed previous findings of some copy number variants already associated with autism, but they also found a host of other genes (SHANK2, SYNGAP1, DLGAP2 and the X chromosome — linked DDX53 - PTCHD1 locus) in which mutations seem to be linked to autism.

The team found that people with only one good copy of the gene make roughly half the normal levels of the hormone.

The findings suggest that Turner women who receive a copy of the X chromosome from the father (and normal women, who get a copy from each parent) are more adept at social skills, although it's unclear which genes might be at work.

Instead, Lolle and Pruitt found that 1 % to 10 % of the offspring produced normal flowers, indicating that at least one copy of the mutant gene had reverted to the nonmutated wild - type.

They did, however, find copies of genes related to CDR1, CDR2, and few others that encode other transporters associated with drug resistance — although the way they function in C. krusei is unknown.

In search of an explanation, the scientists combed through the African elephant genome and found at least 40 copies of genes that code for p53, a protein well known for its cancer - inhibiting properties.

C. krusei, they found, has few copies of gene families associated with pathogenesis in C. albicans, including oligopeptide transporters, aspartyl proteases, and phospholipase B genes.

Using postmortem human brain samples, the researchers found that variations in the number of copies of the C4 gene that people had, and the length of their gene, could predict how active the gene was in the brain.

They found that about 3 to 5 percent of female lymphocytes expressed two copies of these genes, as well as two copies of a gene unrelated to immunity.

But Lo's team found more of the healthy allele, suggesting that the fetus had inherited the correct maternal copy of the gene and would not develop beta - thalassaemia.

They found that 10 per cent of these children have copy number variations (CNVs) affecting genes deemed clinically relevant.

Two groups of researchers published the first genome - wide CNV maps, which illustrated that variation in gene quantity is actually quite common: each group found about 12 copy number imbalances per person.

Again, they found reduced survival: Over 10 years, 46 % of women with two copies of NQO1 * 2 survived, compared with 75 % of women with at least one normal NQO1 gene.

The research team found a surprising variety of spontaneous mutations, from simple deletions or insertions to «jumping genes» — elements of DNA that copy and paste themselves into other parts of the genome.

Bellott and his colleagues looked closer at the properties of the ancestral Y chromosome genes and found that the majority of them were dosage - dependent — that is, they required two copies of the gene to function.

A common mood - stabilizing drug, valproate, is found to control manic - like behavior induced in mice with an extra copy of a gene called SHANK3

Researchers found that the gene XIST, which is responsible for inactivating one of the two copies of the X chromosome in cells that store genetic material, works overtime in female patients with mental illnesses, such as bipolar disorder, major depression and schizophrenia.