Sentences with phrase «gene copy number»

While MDA has become the preferred amplification method for projects seeking single - nucleotide variations, labs looking for gene copy number variations often prefer a method called «multiple annealing and looping - based amplification cycles» (MALBAC).

About 90 % of solid tumors display whole - chromosome aneuploidy, while many tumors with diploid karyotypes nonetheless harbor segmental or arm - length aneuploidies that also result in significant gene copy number alterations.

The TGen team performed deep genomic profiling, integrating gene copy number, gene expression and DNA methylation datasets on a collection of 35 breast - brain metastases samples.

In this study, researchers assessed the outcomes of 280 prostate cancer (Cap) patients, and reviewed the DNA «fingerprints» of each patient's tumor (using the patient's initial diagnostic core biopsy) to determine if gene copy number alterations (CNAs), or breaks in CFSs, were related to a less positive response to treatment.

The study for the first time estimates the minimum number of locations in the human genome — 250 to 300 — where gene copy number variation (CNV) can give rise to autism spectrum disorder (ASD).

Quantitative PCR analysis of 16S rRNA gene copy numbers.

In 2008, Wigler proposed that such cases, characterized by changes in gene copy number — duplicated or deleted genome segments that leave an individual with extra or missing copies of one or more genes — likely account for at least half of ASD cases.

How many human Mendelian and complex traits are due to structural changes and / or gene copy number variation (CNV)?

Using a set of molecular features (e.g., mutations, gene copy numbers, expression patterns) from each cell line, the team also generated biomarker - based models that helped explain the biology behind 426 of the 769 dependencies.

38) Yamamoto H, Shigematsu H, Nomura M, Lockwood WW, Sato M, Okumura N, Soh J, Suzuki M, Wistuba II, Fong KM, Lee H, Toyooka S, Date H, Lam WL, Minna JD, Gazdar AF (2008) PIK3CA mutations and gene copy number in human lung cancers.