Sentences with phrase «gene data in»

Not exact matches

Spark Therapeutics» stock soared 20 % in Wednesday trading on the heels of its second quarter 2017 earnings report and some (very) early data on the gene therapy - focused firm's treatment for the blood disorder hemophilia A.

Abeona Therapeutics (ABEO)- Data for ABO - 102 in MPS IIIA appears encouraging to me (decreases in heparan sulfate, neurocognitive benefits), initial data for ABO - 101 in MPS IIIB showed early promise, EB - 101 in RDEB could see an expedited path to market if the pivotal study yields fruit, and other gene therapy candidates are soon to enter the cliData for ABO - 102 in MPS IIIA appears encouraging to me (decreases in heparan sulfate, neurocognitive benefits), initial data for ABO - 101 in MPS IIIB showed early promise, EB - 101 in RDEB could see an expedited path to market if the pivotal study yields fruit, and other gene therapy candidates are soon to enter the clidata for ABO - 101 in MPS IIIB showed early promise, EB - 101 in RDEB could see an expedited path to market if the pivotal study yields fruit, and other gene therapy candidates are soon to enter the clinic.

Katherine High, Spark's president and chief scientific officer, expressed her enthusiasm for the early clinical data related to SPK - 8011: «The encouraging start of our SPK - 8011 clinical trial reinforces the strength of our gene therapy platform, delivers human proof - of - concept in a second liver - mediated disease — a significant achievement in the gene therapy field — and positions us well to potentially transform the current treatment approach for this life - altering disease with a one - time intervention.»

@Chuckles «DNA works because it works and it is a conduit for different species to spread their genes through» = > definition of faith in the absence of data right there.

Data access and analysis tools are being made available for the 3K RGP dataset through the International Rice Informatics Consortium (IRIC), which promotes collaboration in bioinformatics analysis of rice data and provides computational tools to facilitate rice improvement via discovery of new gene - trait associations and accelerated breedData access and analysis tools are being made available for the 3K RGP dataset through the International Rice Informatics Consortium (IRIC), which promotes collaboration in bioinformatics analysis of rice data and provides computational tools to facilitate rice improvement via discovery of new gene - trait associations and accelerated breeddata and provides computational tools to facilitate rice improvement via discovery of new gene - trait associations and accelerated breeding.

Billions of data points on genes, proteins and other molecules are compiled in large files and systematically studied.

By using this tool to analyze their data the scientists were able to catalogue active alleles in a comprehensive set of mouse tissues, or the mouse «Allelome,» and gain an insight into how this differential gene activity is regulated.

McCallion's strategy to make sense of all this data looks at the active genes in cells affected by a disease, groups of genes that interact with one another, their vulnerability to mutation and information from past scientific studies to filter more than a thousand gene candidates for disease risk down to just a handful within any one implicated region.

The data suggest that around 3500 B.C. — roughly the same time that many linguists place the origin of PIE and that archaeologists date horse domestication — Yamnaya genes replaced about 75 percent of the existing human gene pool in Europe.

By comparing the data from the different groups, the researchers identified which genes show differences in their activity.

The investigators mined genetic data from large clinical trials to find individuals with naturally occurring mutations in the NPC1L1 gene that completely shut it down.

After combing through genetic data from over 100,000 individuals, researchers found the genes were more common in people who had trouble getting enough shut - eye.

An apparently new Variant of human serum albumin, albumin Naskapi, has been found in high frequency in the Naskapi Indians of Quebec and, in lower frequency, in other North American Indians.The family and population data of the albumin are consistent with its inheritance as a simple autosomal trait Controlled by a gene designated Al Naskapi.

Data published by the International Human Genome Sequencing Consortium indicate that somewhere between 113 and 223 genes present in bacteria and in the human genome are absent in well - studied organisms — such as the yeast Saccharomyces cerevisiae, the fruit fly Drosophila melanogaster and the nematode Caenorhabditis elegans — that lie in between those two evolutionary extremes.

Our data demonstrate the feasibility of targeted gene disruption in multiple rat strains within 4 months time, paving the way to a humanized monoclonal antibody platform and additional human disease models.

Brains of individuals who died with Huntington's, Parkinson's or no neurological condition were analyzed using sequencing technology that provides a data readout of the activity of all genes in the genome.

Based on the ribosome profiling data, the researchers looked for genes that were being expressed differently in the trained mice, identifying 104 genes in total.

To that end, the US National Center for Biotechnology Information in Bethesda is developing a database, ClinVar, to integrate clinical and genetic data; others, such as DECIPHER, run by the Sanger Institute, handle genetic data such as chromosome rearrangements that can disrupt genes.

The challenge is substantial — the National Center for Biotechnology Information (NCBI) Gene Expression Omnibus repository (GEO) alone contains 80,985 public datasets, spanning hundreds of tissue types in thousands of organisms — and the rapid growth in data makes it difficult for journals or data repositories to «police» whether datasets that should be made publicly available actually are.

Novel abnormalities in the FGFR gene, called FGFR fusions, were identified in a spectrum of cancers, and preliminary results with cancer cells harboring FGFR fusions suggested that some patients with these cancers may benefit from treatment with FGFR inhibitor drugs, according to data published in Cancer Discovery, a journal of the American Association for Cancer Research.

In a new study published in The Quarterly Review of Biology, Dr. Karen Hardy and her team bring together archaeological, anthropological, genetic, physiological and anatomical data to argue that carbohydrate consumption, particularly in the form of starch, was critical for the accelerated expansion of the human brain over the last million years, and coevolved both with copy number variation of the salivary amylase genes and controlled fire use for cookinIn a new study published in The Quarterly Review of Biology, Dr. Karen Hardy and her team bring together archaeological, anthropological, genetic, physiological and anatomical data to argue that carbohydrate consumption, particularly in the form of starch, was critical for the accelerated expansion of the human brain over the last million years, and coevolved both with copy number variation of the salivary amylase genes and controlled fire use for cookinin The Quarterly Review of Biology, Dr. Karen Hardy and her team bring together archaeological, anthropological, genetic, physiological and anatomical data to argue that carbohydrate consumption, particularly in the form of starch, was critical for the accelerated expansion of the human brain over the last million years, and coevolved both with copy number variation of the salivary amylase genes and controlled fire use for cookinin the form of starch, was critical for the accelerated expansion of the human brain over the last million years, and coevolved both with copy number variation of the salivary amylase genes and controlled fire use for cooking.

Sarah also interviews Augustine Kong of the Big Data Institute at the University of Oxford in the United Kingdom about his Science paper on the role of noninherited «nurturing genes.»

But as researchers pool data from thousands of cancer gene tests, some of those benign variants may be reclassified as dangerous, or may become informative in ways that hadn't been anticipated.

«The story could be further enriched if there were data about prestin genes in echolocating birds and other echolocators, such as shrews,» he says.

The wheat genome's data can be searched via the gene identifier in the text search box, or via the bioinformatics BLAST (Basic Local Alignment Search Tool) to compare sequence matches.

Inheriting a single X chromosome exposes men to a host of X-linked diseases, such as hemophilia or Duchenne muscular dystrophy, and researchers hope to use the new data to understand more fully the role of genes in other X-linked conditions.

The new analysis, based on data assembled primarily by graduate student Yan - Jie Feng at Sun Yat - Sen University in Guangzhou, China, focused on the sequences of 95 genes located on chromosomes in the nucleus and how they changed over time.

«It is exciting to find a correlation between brain circuitry and gene expression by combining high quality data from these two large - scale projects,» says David Van Essen, Ph.D., professor at Washington University in St. Louis and a leader of the Human Connectome Project.

Genetic data from ancient Scythian horses indicates that more than 2,000 years of domestication caused changes in horse genes related to mammary gland development and milk production.

Using the new data, Laura Carrel, a geneticist at Pennsylvania State College of Medicine in Hershey, and Huntington Willard, a geneticist at Duke University in Durham, North Carolina, discovered that 15 percent of the genes on the inactivated X chromosome are actually not silenced — and most are likely to be expressed at higher levels overall in women than men.

The largest of its kind, the study examined genetic data in 100,000 individuals including 40,000 people with a diagnosis of schizophrenia and also found that some of the genes identified as increasing risk for schizophrenia have previously been associated with other neurodevelopmental disorders, including intellectual disability and autism spectrum disorders.

Finally, the authors addressed two major challenges for any study that generates large data - sets of individual genes and proteins in model organisms like yeast: How to assemble the data into coherent maps?

In contrast, when the OncoFinder algorithm is applied to the data, a clear correlation between next generation sequencing and microarray gene expression datasets was seen.

Scientists from the Biogerontology Research Foundation (BGRF), a UK - based charity founded to support aging research and address the challenges of a rapidly aging population, propose a new concept for signalome - wide analysis of changes in intracellular pathways, called OncoFinder, which allows for accurate and robust cross-platform analysis of gene expression data.

«For several years the potential for the use of gene expression data in research and clinical applications has been underappreciated due to the inconsistency of the data coming from the various types of equipment.

They compared each individual's lifespan to that of their relatives and their degree of separation and found that genes explained about 16 percent of the longevity variation seen in their data — on the low end of previous estimates which have ranged from about 15 percent to 30 percent.

The scientists» analyses detected antibiotic resistance gene determinants in all 71 environments represented in the public data, including soil, oceans, and human feces.

Using genetic data from more than 36,000 people with a variety of autoimmune diseases, researchers found that one genetic variant in the gene that codes for the TYK2 protein...

Co-senior author Professor Jennifer Nichols at the Wellcome Trust - Medical Research Council Stem Cell Institute, said: «Our data allow us to study gene activity in individual cells to an unprecedented level of precision.

In all, the study included the data of more than 23,000 people to show that approximately 12 percent of a person's variation in delay discounting can be attributed to genetics — not a single gene, but numerous genetic variants that also influence several other psychiatric and behavioral traitIn all, the study included the data of more than 23,000 people to show that approximately 12 percent of a person's variation in delay discounting can be attributed to genetics — not a single gene, but numerous genetic variants that also influence several other psychiatric and behavioral traitin delay discounting can be attributed to genetics — not a single gene, but numerous genetic variants that also influence several other psychiatric and behavioral traits.

Using computational data analysis, Hughes hopes to create evolutionary trees of these genes and regulatory mechanisms in order to figure out how they work together to make cells function and how they contribute to the physiology of the organisms they are found in.

Using genetic data from more than 36,000 people with a variety of autoimmune diseases, researchers found that one genetic variant in the TYK2 gene protects against a wide range of...

Many genes are likely to influence delay discounting; and some of Dr. Ahokhin's preliminary data suggest that these «impulsivity genes» may include genes coding for enzymes that synthesize the neurotransmitter serotonin and receptors where serotonin binds in the brain.

To figure out what's really happening within an organism — or within a particular organ or cell — researchers are linking the genome with large - scale data about the output of those genes at specific times, in specific places, in response to specific environmental pressures.

The researchers from Queen Mary University of London sequenced the HAS2 gene in thirteen similar or related mammals, combining the data with DNA sequences extracted from 57 published genomes representing all the major mammal groups.

Researchers analyzed the genetic sequencing data of 718 multiple myeloma patients and found that African - Americans had increased mutations in the genes BCL7A, BRWD3 and AUTS2, while white people had more mutations in the genes TP53 and IRF4.

In this study, a team led by Panos N. Papapanou, DDS, PhD, professor and chair of oral, diagnostic and rehabilitation sciences at the College of Dental Medicine at CUMC, «reverse - engineered» the gene expression data to build a map of the genetic interactions that lead to periodontitis and identify individual genes that appear to have the most influence on the disease.

Our data indicate that gene expression is coordinately regulated, such that states of increased proliferation are associated with widespread reductions in the 3 ′ UTR - based regulatory capacity of mRNAs.

These data suggest that new genes frequently and rapidly evolve essential functions and participate in development.

One gene that controls this pathway, HDAC7, is known to be a key factor in immune tolerance and the new data strongly suggests exploring the possibility that drugs affecting HDAC7 function may serve as future therapeutics in PSC.