Sentences with phrase «gene deletion»

"Gene deletion" refers to the removal or elimination of a specific gene from an organism's genetic material. This can happen naturally or through intentional genetic engineering techniques. Essentially, it means that a particular gene is no longer present in an individual's set of genes, potentially affecting their traits, characteristics, or functions. Full definition
«If you look at a cancer cell, it looks like an unholy mess with gene deletions and amplifications, chromosome gains and losses, like someone threw a stick of dynamite into the cell.
The Gross Lab at UCSF recently deposited 2 Bacillus subtilis libraries with Addgene — the B. subtilis Single Gene Deletion Library — Kanamycin and the CRISPRi Essential gene Knockdown library.
The study, which brings together specialist skills in mouse gene deletion and bone measurement to assess the strength of bones in 100 mutant mouse lines, is the largest reported screen of its type for genes that regulate bone health.
Such methods include cell fusion, microencapsulation and macroencapsulation, and recombinant DNA technology (including gene deletion, gene doubling, introducing a foreign gene, and changing the positions of genes when achieved by recombinant DNA technology).»
Korenberg was the early pioneer of studying these individuals with partial gene deletions as a way of gathering clues to the specific function of those genes and gene networks.
The researchers were studying a well - established mouse model that forms a significant number of CCMs following the injection of a drug to induce gene deletion.
By searching for gene deletion patterns in cancer through a concept the investigators call «synthetic essentiality,» the team identified a synthetic essential gene known as chromatin helicase DNA - binding factor (CHD1) as a therapeutic target for prostate and breast cancers lacking a tumor suppressor gene called phosphatase and tensin homolog (PTEN).
Associate Professor Amanda Sainsbury - Salis expressed surprise at the impact of the Y6 gene deletion on mice, commenting «I find it amazing that one gene, which is expressed in the small part of the brain that controls the body clock, has such a profound impact on how much fat is stored on the body, and how much lean tissue is maintained.»
The only DNA in the cells is the designed synthetic DNA sequence, including «watermark» sequences and other designed gene deletions and polymorphisms, and mutations acquired during the building process.
«Using gene deletion analysis and animal infection models, we identified that the Arg1 metabolic pathway allows Cryptococcus to establish a lung infection and to spread to brain, resulting in meningitis.
• A patient's undifferentiated small bowel sarcoma was found to contain a KIT gene deletion, resulting in a revised diagnosis of GIST (gastrointestinal stromal tumor) that was successfully treated with imatinib.
A study at the University of North Carolina found that gene deletion poses a threat to Malaria eradication efforts.
By using a mouse model of conditional APC gene deletion in MuSCs we further demonstrated that the massive activation of canonical Wnt signaling in MuSC following APC loss results in defective cell cycle progression and apoptosis.
Gallagher CJ, Muscat JE, Hicks AN, Zheng Y, Dyer A, Chase GA, Richie JP Jr., Lazarus P. Sex - specific association of the UDP - glucuronosyltransferase 2B17 gene deletion with decreased glucuronidation of NNAL and increased risk for lung cancer.
«When it became clear that Williams Syndrome is caused by a microdeletion of genes, we could start looking at smaller and smaller gene deletions to study their effect on social behavior.»
Very rarely, an individual with Williams syndrome has a slightly smaller or larger gene deletion than is typical for the syndrome.
«Further parsing the effects of GTF2IRD1 versus GTF2I on spatial construction and social behavior was previously hampered by the small number of cases with fewer than the usual gene deletions and limited cognitive data,» explains Korenberg.
Effects of Bax gene deletion on social behaviors and neural response to olfactory cues in mice.
Citation: A comprehensive analysis of replicative lifespan in 4,698 single - gene deletion strains uncovers novel mechanisms of aging
Gene deletion mutants of the same pathway or with similar fitness alterations in steady conditions can largely differ in their response to dynamic conditions.
The single - gene deletion library is derived from the B. subtilis 168 strain and contains knockouts for all 3984 genes identified as non-essential.
We, at Liverpool, have amassed a data bank of Bedlingtons affected by copper toxicosis but lacking the COMMD1 gene deletion and possessing microsatellite DNA markers 1 - 1 or 1 - 2.
The two groups began the painstaking process of examining 4,698 yeast strains, each with a single gene deletion.
CRS - 207 is a live, attenuated Listeria monocytogenes bacterium that contains two gene deletions to diminish its pathogenicity and has also been engineered to express mesothelin.
Normal - weight mice with kidney disease and defective autophagy (due to a gene deletion) also experienced kidney cell damage.
(In one common system, the virus is engineered with a gene deletion that prevents replication in healthy neurons.)
The researchers used a genetic technique called «gene deletion,» which involves removing a specific gene in a bacterial strain and observing the consequences.
It was then that they discovered the gene deletion had caused thin heart walls and other cardiac problems in developing mice embryos.
«A gene deletion that up - regulates viral gene expression yields an attenuated RSV vaccine with improved antibody responses in children» was written by Ruth A. Karron; Cindy Luongo; Bhagvanji Thumar; Karen M. Loehr; Janet A. Englund; Peter L. Collins; and Ursula J. Buchholz.
«We will need to conduct tests in more patients who do not have all the gene deletions seen in typical Williams syndrome, and compare and contrast genetics and behavior.»
The team characterized the effects of the gene deletion and found that the mice had symptoms similar to those experienced by patients with BAD.
Southern blot analysis confirmed target gene deletion.
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