Meanwhile,
gene delivery systems other than retro - or lenti - viral ones, such as repeated transfection with plasmids and use of a non-integration virus, have been successfully applied in generation of iPS cells [8], [9].
Neurons of the peripheral nervous
system (PNS), which connect the heart, lung, gut, and
other organs to the CNS, are also an important target for
gene delivery, especially for the study of pain.