Sentences with phrase «gene discovery research»

«The diagnostics lab Baylor Genetics is one of the pioneers in this new era of clinical genomics - supported medical practice and disease gene discovery research,» Lupski said.

Not exact matches

In 2015, the viral «Ice Bucket Challenge» helped fund groundbreaking research that led to the discovery of a gene associated with the disease.

«For many years, we have searched for genes that improve phosphorus uptake,» said Dr. Sigrid Heuer, senior scientist at the International Rice Research Institute (IRRI) and leader of the team that published the discovery in Nature.

The recent Lancet Breastfeeding Series refers to new discoveries being made about breastmilk — such as its role in gene expression — so it can be expected that Nestle will use the strategy of launching «new improved» formulas that are «closer to breastmilk» for decades to come (Nestle is currently investing heavily in epigentics research).

Within just three years since the discovery of its gene - editing potential, the new technique Crispr has become the hottest, and most controversial, development in genomics research.

For many molecular biologists, the discovery of the CRISPR - Cas9 system marked a new milestone in research: finally, genomic DNA can be cut with high efficiency and precision, enabling genes to be disabled, modified or re-introduced.

According to the responses, the research discoveries most likely to play a part in this year's blockbuster are gene - editing technology, xenotransplantation, and artificial intelligence.

The revolution in obesity research began less than five years ago with the landmark discovery of a gene for leptin, the weight - regulating hormone found in both mice and people.

Thus, the discovery of DNA methylation in early diverging fungi helps the research community better understand regulation of genes that encode the parts for bio-based economy and bioenergy applications.»

The discovery is being hailed by experts in the field, including Dr. Ronald Worton, who co-discovered the gene for Duchenne muscular dystrophy in 1987 and served as Vice-President of research at The Ottawa Hospital for 11 years.

«This is a very important discovery that will guide future research efforts to explore the interactions of these pigmentary genes with other genetic and environmental risk factors in cancers not linked to sun exposure, such as eye melanoma.

The study points to a future of active gene discovery for mental disorders» said Thomas Lehner, Ph.D., chief of the NIMH Genomics Research Branch, which funds the project.

The studies on autophagy by Yoshinori Ohsumi, which earned him the Nobel Prize in Medicine in 2016, and the discovery of cell cycle regulatory genes for which Leland Hartwell, Timothy Hunt and Paul Nurse received the same award in 2001, including the research of Elizabeth Blackburn, Carol Greider and Jack Szostak on telomeres, telomerase and its protective effect on the chromosomes, were all made possible thanks to yeast.

In addition to publishing the discovery of the «speed gene» — actually a gene that controls the expression of the muscle growth factor, myostatin, in a January 2010 Public Library of Science paper — she has published research on several more genes and is seeking patents for some, including myostatin (MSTN).

Kidney research at the University of Virginia School of Medicine has unexpectedly led to a discovery about the formation of the heart, including the identification of a gene responsible for a deadly cardiac condition.

It is expected that the new technique will be applied to gene therapy in the future in addition to providing a powerful tool for breeding useful organisms and conducting disease and drug - discovery research.

In a paper in the high - impact journal Cell Research, published April 4, 2017, researchers at the Hebrew University of Jerusalem report the discovery of an entirely new mechanism through which globin genes are expressed.

Scientists were less gushing but equally excited — the discovery sparked a frenzy of research aiming to uncover the gene's role.

Previous studies have shown a physiologic role for vitamin D in liver function, but «it was our discovery of high levels of vitamin D receptor (VDR) in the stellate cell that led us to consider it as a possible off switch for liver fibrosis,» says lead author Ning Ding, a research associate in the Gene Expression Laboratory.

Research into ageing is a young field that has seen immense progress in recent years, galvanised by discoveries that single gene mutations and dietary restriction can extend healthy lifespan.

Dr. Kanner brings more than 25 years of experience in drug discovery and development and will lead Caribou's research and development of new applications for its gene editing technology.

While advancing this target discovery work, deCODE will also bring to the alliance its Clinical Genome Miner ™ system in order to validate and prioritize targets emerging from Merck's substantial research programs in mice and gene - expression.

Reykjavik, ICELAND, 12 October 2011 — deCODE genetics today announced that it has entered into a research collaboration with Pfizer Inc., the objective of which is to discover sequence variants associated with specific clinical phenotypes related to Systemic Lupus Erythematosis by utilizing deCODE's expertise in gene discovery.

deCODE has identified key variations in the sequence of the genome conferring increased risk of major public health challenges from cardiovascular disease to cancer, and employs its gene discovery engine to develop DNA - based tests to assess individual risk of common diseases; to license its tests and intellectual property to partners; and to provide comprehensive, leading - edge contract services to companies and research institutions around the globe.

Dr. Innocentis NIH - funded research program is currently focused on the discovery of genomic determinants of efficacy and toxicity of cancer chemotherapy, integrating clinical genomic investigation with functional evaluation of gene variation.

Working in widespread collaborations and research networks, Julia and her colleagues have ensured that the discovery of the mechanism by which the SUB1A gene contributes to the submergence tolerance of rice has resulted in improved varieties that have been rapidly adopted.

Washington, D.C. — April 18, 2018 — The Clinical Research (CR) Forum, a non-profit membership association of top clinical research experts and thought leaders from the nation's leading academic health centers, today awarded its most prestigious honor to a Massachusetts General Hospital research team for its discovery of the first successful gene therapy treatment for a fatal brain disease, cerebral adrenoleukodystrophResearch (CR) Forum, a non-profit membership association of top clinical research experts and thought leaders from the nation's leading academic health centers, today awarded its most prestigious honor to a Massachusetts General Hospital research team for its discovery of the first successful gene therapy treatment for a fatal brain disease, cerebral adrenoleukodystrophresearch experts and thought leaders from the nation's leading academic health centers, today awarded its most prestigious honor to a Massachusetts General Hospital research team for its discovery of the first successful gene therapy treatment for a fatal brain disease, cerebral adrenoleukodystrophresearch team for its discovery of the first successful gene therapy treatment for a fatal brain disease, cerebral adrenoleukodystrophy (ALD).

For the most part, the research has focused on the discovery of a complex cascade of genes that combine to form molecular pathways needed to help youthful cells, tissues and organs decide in which direction to take their first fateful steps — whether to go left or right.

When the skin cell sample is taken from someone with a specific disease, those iPS cells contain a complete set of the genes associated with the illness, and disease models can be developed to facilitate research and drug discovery.

«Historically, we have had trouble modeling human diseases caused by mutation of just one copy of a gene in mice, which impedes research on complex conditions and limits our discovery of therapeutics,» explained Srivastava, director of the Gladstone Institute of Cardiovascular Disease and senior author on the study.

Cenix BioScience is a contract research organization focused on the discovery and pre-clinical development of novel therapeutics, specializing in advanced applications of RNA interference (RNAi) gene silencing combined with high content phenotyping in cultured cells in vitro and in animals in vivo.

With its uniquely comprehensive population data, deCODE is turning research on the genetic causes of common diseases into a growing range of products and services — in gene discovery, pharmaceuticals, DNA - based diagnostics, pharmacogenomics, in silico discovery tools, bioinformatics and medical decision support systems.

Dr. Shendure's research group in Seattle pioneered exome sequencing and its earliest applications to gene discovery for Mendelian disorders (e.g. Miller and Kabuki syndrome) and autism; cell - free DNA diagnostics for cancer and reproductive medicine; massively parallel reporter assays and saturation genome editing; whole organism lineage tracing; and massively parallel molecular profiling of single cells.

The discovery is being hailed by experts in the field, including Dr. Ronald Worton, who co-discovered the gene for Duchenne muscular dystrophy in 1987 and served as Vice-President of Research at The Ottawa Hospital from 1996 to 2007.

Coupled with a new gene - signature approach, this research project could identify compounds that will ultimately lead to the discovery of new neuropsychiatric drugs.

Research funded by E-Rare has a great impact on life patients supporting the understanding of the natural history of disease, the discovery of new causative deases genes or the discovery of innovative therapeutic approaches.

Wistar discoveries have led to the development of vaccines for rabies, rubella, and rotavirus, the identification of genes associated with different types of cancer, the development of monoclonal antibodies, and other significant research technologies and tools.

Lloyd Trotman's recent research path begins at his discovery some years ago that the loss of a single copy of a master tumor suppressing gene called PTEN is sufficient to permit tumors to develop in animal models of prostate cancer.

Ten years ago, Shinya Yamanaka revolutionized biological research with his discovery of how to turn ordinary skin cells into stem cells with just four key genes.

Research appearing in Developmental Cell details the discovery of genes located in two genomic regions whose copy numbers are increased in response to differentiation of the ovarian follicle cells.

This research has enabled novel gene discovery and uncovered the different genetic mechanisms underlying both isolated congenital heart disease and that which occurs in association with other medical problems.

194/6: 45 Improving diagnosis and furthering gene discovery through recruitment of clinical whole exome sequencing cases into research.

Our researchers have made key discoveries of the specific gene mutations and proteins involved in both syndromic and non-syndromic congenital sideroblastic anemias, and we have an open research protocol that is helping us to reach our ultimate goal of understanding the genetic basis of all types of CSAs.

With its uniquely comprehensive population data, deCODE is turning research on the genetic causes of common diseases into a growing pipeline of products and services — in pharmaceuticals, gene and drug discovery, DNA - based diagnostics, pharmacogenomics, bioinformatics, and clinical trials.

By focusing innovative research on genes and proteins it aims to contribute to the betterment of people by its discoveries relating to the causes, treatments, and prevention of diseases.

The mission of the Cancer Mechanisms Research Program (CM) is to foster interdisciplinary collaborations and accelerate progress along the translational continuum between gene discovery and genotype - informed molecular treatments.

Combined efforts of the dedicated Miniature Poodle breeders and the research team led by Dr. Mark Neff at the Van Andel Research Institute culminated in the discovery of a partial deletion of the sulfate transporter gene, SLC13A1, as a cause of the osteochondrodysplasia in this breeresearch team led by Dr. Mark Neff at the Van Andel Research Institute culminated in the discovery of a partial deletion of the sulfate transporter gene, SLC13A1, as a cause of the osteochondrodysplasia in this breeResearch Institute culminated in the discovery of a partial deletion of the sulfate transporter gene, SLC13A1, as a cause of the osteochondrodysplasia in this breed (2,3).

A collaborative research effort by a team of investigators at the University of Pennsylvania, veterinary ophthalmologist Dr. Chris Dixon and the OptiGen Research Program, has led to the discovery of a novel mutation in the CNGA3 gene that causes Day Blindness in the Labrador Retrieresearch effort by a team of investigators at the University of Pennsylvania, veterinary ophthalmologist Dr. Chris Dixon and the OptiGen Research Program, has led to the discovery of a novel mutation in the CNGA3 gene that causes Day Blindness in the Labrador RetrieResearch Program, has led to the discovery of a novel mutation in the CNGA3 gene that causes Day Blindness in the Labrador Retriever (1).

Dr. Mellersh performed the initial research (1,2) that provided information vital to the discovery of the Cord 1 gene mutation in English Springer Spaniels and the subsequent development of the test by Dr. Gary Johnson of the University of Missouri.

While people may have written off the «ice bucket challenge», used to raise money and awareness for Amyotrophic Lateral Sclerosis (ALS) or Lou Gehrig's disease, as just a social media flash in the pan, the money raised by people participating in the challenge and their supporters funded the research that led to the discovery of the gene (NEK1) that causes ALS.