Sentences with phrase «gene dosage»
"Gene dosage" refers to the number of copies or amount of a specific gene present in a cell or an organism. It determines the level of proteins or other molecules produced by that gene, which can affect the overall function and characteristics of an organism. Full definition
The results suggest that subtle changes in gene dosage across many genes, caused by the change in chromosome numbers, can promote alternate behaviors.
sciencedaily.com
Just a few months ago, I reviewed a paper demonstrating that regulatory variation near genes predicts gene dosage sensitivity.
Here we will use it to seek evidence for an increased dependence of protein function on gene dosage upon aging.
Rui Yi, Ph.D., CU - Boulder: Determine the effect of gene dosage imbalance on activity in trisomic embryonic stem cells
The research team, headed by Montserrat C. Anguera, an assistant professor in the Department of Biomedical Studies at Penn's School of Veterinary Medicine, focused on X inactivation, a mechanism that serves to balance gene dosage between males and females by inhibiting gene expression on one of a female's two X chromosomes.
Title: Mirror extreme BMI phenotypes associated with gene dosage at the chromosome 16p11.2 locus Author: S. Jacquemont et al..
Rather gene dosage, which depends on the number of chromosome copies, is responsible for this: «If the chromosome is multiplied, then more copies of the same gene will be transcribed.
We are also applying CRISPR / Cas9 - mediated genome engineering to develop novel mouse models in order to explore the impact of gene dosage alterations on tumor development in vivo.
While a process called X chromosome inactivation serves to balance out gene dosage between males and females, some genes on the «inactive X» chromosome in immune cells can sometimes escape this process, giving women an extra dose of immunity - related gene expression.
In studying the regulation of gene dosage, his lab described the first known biological role of a microRNA in the mammalian system, ultimately revealing a network of microRNAs that titrate the dose of key cardiac gene networks that dictate cell fate and differentiation.
There also was a gene dosage effect: Two copies of the variant (one inherited from each parent) resulted in an additive aging effect of six to eight years — meaning that a 50 - year - old carrying two copies of the variant had the telomeres of someone aged 58.
Our data also suggest a gene dosage effect on decreasing firing rate in STN neurons, since the probability of detecting spontaneously active units in Homo mice is significantly lower than Het.
A hallmark of the Notch pathway is its gene dosage sensitivity, such that small differences in the amount of Notch activity can cause aberrant cell fate choices and T - cell leukemia.