Sentences with phrase «gene drive elements»

Importantly, our divergent guide RNAs will also enable global CRISPR gene drive elements to overcome the problem of instability caused by including multiple repetitive guide RNA sequences in the drive cassette [34], which in turn is required in order to overcome drive - resistant alleles [35].

RNA - guided gene drive elements could address many ecological problems by altering the traits of wild organisms, but the likelihood of global spread tremendously complicates ethical development and use.

To date, gene drive elements based on Cas9 have been demonstrated in yeast [3], fruit flies [4], and two species of mosquito [5][6].

These elements function by «homing», or the conversion of heterozygotes to homozygotes in the germline, which renders offspring more likely to inherit the gene drive element and the accompanying alteration than via Mendelian inheritance (Fig. 1a)[2].

Not exact matches

They speculate that the investigation of factors that bind this specific element could help in elucidating molecular mechanisms that drive the selective J - element dependent gene expression.

Gene drives are systems of biased inheritance that enhance a genetic element's ability to pass from parent organism to offspring.

Kevin Esvelt (Harvard University, Massachusetts) spoke about gene drives — types of genetic elements that drive themselves through populations by distorting inheritance in their favor.

This generic daisy drive system, which would harbor the Cas9 gene in the B position but lack any A elements, could be used in three different ways.