Sentences with phrase «gene drive mechanism»

Laboratory and field research is needed to refine gene drive mechanisms and better understand how gene drives work, from the molecular level through species and ecosystem levels.

Not exact matches

What drew them into this exploratory process was not a Darwinian drive to the enhanced propagation of their genes, but an entirely different mechanism.

Or, as Esvelt's lab suggested in June 2016, drive components could be scattered throughout a genome so the driving mechanism fades from the gene pool as generations pass.

To more accurately reflect the mechanisms driving oligodendrogliomas, the researchers used RNA sequencing to study directly, on a single - cell level, gene expression in samples from six early - stage human tumors.

But some of the most powerful forms of gene drives are hard to control or reverse, and without the proper biosecurity mechanisms they could theoretically spread beyond the target population to impact an entire species.

Over several years, Dr. Stewart and colleagues unraveled genes and signaling pathways that drive multiplication (proliferation) of beta cells, and then confirmed proposed mechanisms with gene therapy.

Although bacteria have a seemingly limitless capacity to alter their genes by swapping bits of DNA between strains, this mechanism doesn't seem enough to account for the swift pace of change and the high variability of E. coli and other strains.Thomas Cebula of the U.S. Food and Drug Administration (FDA) wondered if this rapid evolution is being driven by microbes capable of much faster - than - normal variation.

While further work will be required to fully understand the mechanism driving the recombination of Plasmodium falciparum's var genes, scientists were able to calculate the rate at which it happens.

One of the mechanisms driving alterations in gene expression is epigenetic change, where the female is able to change her offspring's genome to cause certain genes to be expressed differently.

They speculate that the investigation of factors that bind this specific element could help in elucidating molecular mechanisms that drive the selective J - element dependent gene expression.

The report recommends that the governing authorities, including research institutions, funders, and regulators, develop and maintain clear policies and mechanisms for how public engagement will factor into research, ecological risk assessments, and public policy decisions about gene drives.

Fourth, the observed autosomal divergence of gain and loss hotspot patterns in proximity to genes supports a model in which developmental / regulatory mechanisms (based on GO term results) are robust to large amounts of transposon driven DNA gain and loss.

Conversely, fundamental research using mouse models can identify genes associated with disease and provide insights into pathogenic mechanisms underlying environment - driven diseases, including infectious diseases and cancer.

Our results reveal the regulatory mechanisms that interplay to drive transcription factor occupancy, chromatin state, and gene expression in complex mammalian cell states.

But the absence of these two genes in the tumors was not enough to completely drive metastasis, there was still an unknown mechanism at play.

The single - cell perspective has helped to better understand gene regulation and regulatory networks during exit from pluripotency, cell - fate determination as well as molecular mechanisms driving cellular reprogramming of somatic cells to induced pluripotent stage.

The new «gene drive» mechanism has the potential to reduce or completely extirpate a population of rapidly reproducing sexual organisms such as mosquitoes, fleas, tree - killing insects, and invasive non-native plants and animals.

Dr. McCleary - Wheeler's research interests focus on uncovering the molecular mechanisms driving cancer development and progression through detailed investigations into the regulatory mechanisms governing gene expression.

Advances in neuroscience have revealed that the process of brain development is driven by a dynamic interaction between the genome (nature) and the environment (nurture).25 Epigenetic mechanisms like DNA methylation and histone acetylation are able to transduce experiences with the environment into long - lasting, even intergenerational changes in gene expression.26 — 35 So although the inherited genetic program is thought to provide a general blueprint for brain architecture, the environment is able to influence which genes are used, when they are used during the course of development, and where they are used within the developing brain.