Recent breakthroughs in evolutionary genomics show that a burst of
gene duplications occurred in the human lineage during its separation from non-human primates approximately 6 million years ago (Bailey et al., 2002; Fortna et al., 2004; Marques - Bonet et al., 2009).
Not exact matches
Gene moonlighting can
occur merely through changes in expression, which may result from as little as a single mutation; it does not require the meandering process of random alteration and selection implied by the
duplication and neofunctionalization model.
The upper panel shows the distance of read pairs; the insertion of the region probably
occurred after the
duplication of the
gene into the subtelomeres, as all reads from the
duplications are connected over the insertion.
Recently, we showed that
duplication of a
gene (TBK1) causes some cases of a form of glaucoma that
occurs at low eye pressure.
Altogether, the data presented in this study reinforces the evolutionary importance of the two rounds of whole genome
duplication that
occurred in the vertebrate ancestor and sheds light on the differential behaviour of
gene duplicates that arose in these events.