Sentences with phrase «gene encodes a protein which»

«This gene encodes a protein which recognises the presence of a certain number of cold - inducing microbes in a cell, such as the respiratory syncytial virus (RSV) or rhinoviruses,» explains Samira Asgari of EPFL, who designed the experiments.

Not exact matches

As the video explains, these traits are due to the tiny molecular machines in our cells known as proteins, which are encoded by bits of DNA called genes.

Humans have roughly 20,000 to 25,000 genes, which encode proteins that perform vital jobs in our cells.

Using a gene - sequencing technique known as whole - exome sequencing that targets only the DNA that encodes proteins, the researchers cataloged virtually every significant DNA variant in three families in which the condition is common.

The huntingtin gene encodes a large scaffold protein, with many interaction partners, which is thought to be involved in intracellular trafficking.

In humans, Huntington's is an inherited disease caused by a gene encoding a toxic protein, called mutant huntingtin, which causes brain cells to die.

The last gene of interest was TGM5, which encodes a protein that stabilizes protein groups.

No. 5,817,479, entitled Human Kinase Homologs, claims 44 ESTs which are fragments of genes encoding protein kinases.

It was a gene called the von Hippel - Lindau (VHL) factor, which encodes a protein that puts a brake on the cellular hypoxia response.

He discovered a second clock gene, called timeless, that encodes another protein, TIM, which is required for a normal circadian rhythm.

A screen for mouse genes dependent on dHAND, a transcription factor implicated in neural crest development, identified Ufd1, which maps to human 22q11 and encodes a protein involved in degradation of ubiquitinated proteins.

What emerged from their work was the finding that the girl had inherited two differently mutated copies of the gene IRF7, which encodes a protein that amplifies the production of interferon, a critical part of the body's response to viral infections.

Researchers would then have to pore through four or five databases for each one, trying to discern which genes (or the proteins they encode) have features most likely to affect the biology of the disorder — a painstaking task.

Mutation around the region of the human SOX9 gene, which encodes the Sox9 protein, causes campomelic dysplasia, a congenital disease that is accompanied by skeletal abnormalities and other conditions.

The research team used mass spectrometry to compare phosphorylation of proteins from mouse embryonic stem cells with fully functioning GSK - 3 to cells in which the gene encoding GSK - 3 had been deleted.

Our genes can be thought of as packets of information written in sequences of DNA bases, which encode proteins that perform the functions necessary for life.

For the research, conducted in the insectary at the Johns Hopkins Malaria Research Institute in Baltimore, Dimopoulos and colleagues modified Anopheles gambiae mosquitoes by deleting the gene FREP1, which encodes an immune protein, fibrinogen - related protein 1.

Her research team placed the evolutionarily conserved castor (Cas) gene, which encodes a zinc finger protein, in a genetic circuit with two other evolutionarily conserved genes, hedgehog (Hh) and eyes absent (Eya), to determine the fates of specific cell progeny (daughters).

For example, they found also accelerated adaptation for a gene encoding a lung surfactant protein (SFTPB), which may have been due to lung changes necessary for diving.

Women prefer the smell of T - shirts worn by men whose major histocompatability complex genes — which encode the proteins that make up an important part of our immune system — are different from their own, and vice versa.

Their young patient had a severe form of the disease known as junctional EB, caused by a mutation in a gene encoding part of the protein laminin 332, which makes up a thin membrane just below the epidermis.

9 Mimivirus contains more than 900 genes, which encode proteins that all other viruses manage to do without.

About half of melanoma patients harbor an identical tumor - specific mutation in the BRAF gene, which encodes a protein kinase that helps drive cell growth.

If the gene encoding a protein is duplicated in the genome, which often happens in evolution, original and copy will interact with the same partners in the protein network.

They found amplification of several such genes, specifically CD274 (which encodes the PD - L1 immune checkpoint protein) and PDCD1LG2 (which encodes the PD - L2 immune checkpoint protein).

The researchers anticipate that the pigs could be a practical way to test treatments for HD, which is caused by a gene encoding a toxic protein that causes brain cells to die.

Hutchinson - Gilford progeria is caused by a spontaneous mutation during conception in a gene called LMNA, which encodes a protein called prelamin A. Progeria patients experience a buildup of an abnormal version of prelamin A in their cells that, among other changes, distorts the nucleus and alters gene expression.

The gene, on chromosome 18, encodes a protein called MBP which forms part of the myelin sheath surrounding nerves.

The team singled out the gene Mecp2, which encodes a protein that regulates the expression of genes that help forge connections between nerve cells.

That gene encodes a protein called BAF 180, which is a subunit of the PBAF subtype of the SWI / SNF chromatin remodeling complex.

To tease out what the LucA protein does, VanderVen's team created a novel LucA Mtb mutant, which revealed that the protein encoded by the gene LucA is an integral membrane protein required for fatty acid and cholesterol uptake in Mtb.

The genes which encode these proteins therefore originate from the last common ancestor of mosses and flowering plants — the prehistoric plants which left the fresh water to dwell on rocks and thus laid the foundation for the development of all current ecosystems on the mainland.

The GJB6 gene encodes the CONNEXIN 30 protein, which is essential in hearing development, and a deficiency of the gene results in the second most common disease among cases of hereditary hearing loss that have no other disease in the inner ear.

The gene SWEET4c, which encodes a sugar transporter protein in maize, was shown to be specifically expressed in the maize seed by the group of Prem Chourey at University of Florida, and had evidence of selection due to domestication.

Wolfram syndrome is caused by a mutation in the gene encoding a protein called wolframin, which resides in the membrane of the endoplasmic reticulum — another cellular compartment that functions as a manufacturing and packaging system and also acts as a reservoir for calcium ions.

Alexander Pletnev and colleagues at the National Institute of Allergy and Infectious Diseases in Bethesda, Maryland, and the nearby Walter Reed Army Institute of Research have taken two genes from West Nile virus that encode proteins that form the outer envelope of the virus, and spliced them into the dengue virus type 4, which does not attack the central nervous system.

Through the combination of linkage data and exome sequencing, they have identified a deletion or loss of a single base in the gene encoding STAG3, which results in a prematurely truncated protein without function.

FXS is caused by a mutation in the gene fmr1, which encodes the fragile X mental retardation protein, FMRP.

The newly identified mutation affects a gene called APP, which encodes a protein that gets broken down into pieces, including β amyloid.

They can encode several genes potentially involved in protein biosynthesis, a unique feature which has led to diverging hypotheses about the origins of these viruses.

The base was located in the TDPB gene, which encodes a protein called TDP - 43 whose function isn't clear.

The pioneering study, conducted by researchers from the world - leading Sheffield Institute of Translational Neuroscience (SITraN), found that the C9orf72 protein, which is encoded by the C9ORF72 gene, functions in the autophagy pathway — something which is defective in patients with the most common inherited form of ALS and FTD.

Around 50 % of cases of familial recessive Parkinson's disease are caused by mutations in the PARKIN gene, which encodes a protein that belongs to the RBR ubiquitin ligase enzyme family.

The protein encoded by the PIK3C2G gene belongs to the phosphatidylinositol -4,5-bisphosphonate 3 - kinase (PI3K) family, which plays a critical role in cancer.28 Experimental evidence suggests that activation of PI3K signaling enhances production of COX - 2 and PGE2, which results in inhibition of apoptosis in colon cancer cell lines that can be restored with NSAID - mediated blockade of PI3K.29

Previously, Semenza's team generated a virus that carries the gene encoding an active form of the HIF - 1 protein, which turns on genes necessary for building new blood vessels.

Once the bacterial cell signaling protein cagA reaches the host cytosol, it is capable of altering subsequent generations of progenitor cells, leading to the development of cancer through changes in mitotic activity, apoptosis, cellular assembly, and signaling.26 Although it should be noted that while the presence of the cagA protein doubles the risk of gastric cancer, cagA - negative strands also increase the risk of distal gastric cancer.27 Additional H pylori virulence factors include babA2, which encodes bacterial adhesion with gastric epithelial cells, and vacuolating cytotoxin A, which is encoded by the gene vacA.28, 29 H pylori strains carrying some combination of the babA2, cagA, and vacA genes were associated with the highest risk of developing intestinal metaplasia.

In order to control the several genes that are regulated by the flagellum activity and by quorum sensing, we first deleted flaA, which encodes the flagelling core protein, and hapR, which encodes the quorum sensing master regulator.

Then, if you want only certain types of cells to express the protein they encode, you must add a «promoter», i.e. a small DNA sequence which regulates expression, to this gene.

The Pax3 protein, which is encoded by the Pax3 gene, regulates neural tube closure and cardiac neural crest development by blocking the activity of p53, which is a cell - death protein.

The gene encodes a protein called plakophilin 2, which is crucial for the formation and proper functioning of the skin structure, suggesting an aberrant skin barrier as a potential risk factor for atopic dermatitis.