Sentences with phrase «gene enhancers play»
Not exact matches
«Mysterious» non-protein-coding RNAs play important roles in gene expression: Study describes how enhancer RNAs are key to gene expression, possibly cancer mutations.»
https://www.sciencedaily.com/
«Because many broadly expressed genes that play key roles in essential cellular functions are under the control of cell - specific enhancers, the ability to affect enhancer function by knocking down eRNAs could potentially provide a new strategy for altering gene expression in vivo in a cell - specific manner,» said Glass, noting that in his research, anti-sense oligonucleotides were developed in conjunction with Isis Pharmaceuticals, which suppressed enhancer activity and reduced expression in nearby genes.
«We identified, across the genome, that enhancer RNAs were the most common type of RNA that bound to CBP, and that by making this interaction, eRNAs play a crucial role in regulating CBP activity and gene expression.»
He and Duke graduate student Lomax Boyd scanned the genomic databases and combed the scientific literature for enhancers that were different between humans and chimps and that were near genes that play a role in the brain.
«These enhancers can harbour disease - causing mutations which would be missed in traditional studies of genes, but which are suspected of playing an important role in inherited neurodevelopmental and neuropsychiatric disorders.
The researchers found that snippets of DNA called enhancers can boost the frequency of bursts, suggesting that these bursts play a role in gene control.