Sentences with phrase «gene expression across»

«Based on our data, which is comprised of gene expression across 16 brain regions, we found that the most distinct region, i.e. the region where we observe more human - specific differences in gene expression, is the striatum, a region involved in motor coordination, reward, and decision - making,» lead author André M. Sousa of the Yale School of Medicine and the Kavli Institute for Neuroscience told Seeker.

Sexually dimorphic gene expression across organs vary, between 14 % in brain and 70 % in liver, with mostly small effects (185).

Characterization of patterns of gene expression across tissues, individuals and species (Guigo, Estivill and Notredame's groups, Genome Research 2012, Genome Research 2014, Nature 2014, Nature 2014, Nature Communications 2015, Science 2015, PNAS 2015, Genome Biology 2016).

These efforts include theAllen Brain Atlas, which has spatially mapped gene expression across the human brain, and the NIH» sBRAIN Initiative, which is accelerating the development and application of new technologies.

Working with Bhaduri, who has a background in statistics and bioinformatics, Pollen and Nowakowski began exploring how specific classes of neurons and stem cells in the developing brain contribute to normal brain growth as well as to neurodevelopmental disease, and have begun to build a comprehensive, open - source atlas of gene expression across the developing brain, which they hope will serve as a resource for other scientists.

This quite quickly led to technical improvements in how we could observe gene expression across multiple life - forms, leading to new environmental biology discoveries.

After 3 months, the researchers drew blood samples from the monkeys, purified five different types of immune cells, and measured gene expression across their entire genomes.

Specifically, the study reveals a mechanism that helps explain how dividing cells pass patterns of epigenetic information called methyl tags to their daughter cells, a crucial part of regulating gene expression across cell generations.

Not exact matches

Maternal care, gene expression, and the transmission of individual differences in stress reactivity across generations.

Therefore, variation in RNA quality across lactation stage must be considered when interpreting gene expression results across postpartum time points.

For 50 years, the fundamental principles and mechanisms of the epigenetic regulation of gene expression have been explored across myriad organisms and human diseases.

«We used the Allen Human Brain Atlas data to quantify how consistent the patterns of expression for various genes are across human brains, and to determine the importance of the most consistent and reproducible genes for brain function.»

Despite the anatomical complexity of the brain and the complexity of the human genome, most of the patterns of gene usage across all 20,000 genes could be characterized by just 32 expression patterns.

This program, resulting in shorter 3 ′ UTRs, is a characteristic of gene expression during immune cell activation and correlates with proliferation across diverse cell types and tissues.

Bautista, Brem, and collaborators sought out genes whose expression was correlated with itch behavior across genetically distinct mouse strains.

«We identified, across the genome, that enhancer RNAs were the most common type of RNA that bound to CBP, and that by making this interaction, eRNAs play a crucial role in regulating CBP activity and gene expression.»

The researchers in the Greenberg lab found that across all analyzed datasets, and in studies of different mouse brain regions, in the absence of MECP2 the expression of long genes is increased.

- catenin pathway serves as a signaling hub that helps cells across species adjust gene expression in response to their environment.

Across all four cancer types, the new method of selecting candidate genes based on inter-tumor variation in gene expression outperformed the other methods, including the standard method of comparing mean expression in adjacent normal and tumor tissues.

They built a new software tool called MIxT (Matched Interactions across Tissues) that uses computational and statistical methods to find and investigate links between gene expression in different body tissues.

Rather than listing specific genes that manifest themselves differently, or are differentially expressed, between queens and workers, the team looked for genes with similar expression patterns across samples that may be involved in maintaining the structural, behavioural and functional differences observed between queens and workers.

Michael Skinner's claim that chemicals can cause changes to gene expression that persist across multiple generations of animals has stirred excitement — and outrage.

In their new Science paper, the researchers analyzed gene expression in single cells across key developmental time points and from different regions of the brain.

We predicted a link between gene expression evolution across species and the degree of sexual selection, but this is the first statistical evidence for it and shows how powerful sexual selection can be in leading to major changes in how a gene is expressed.»

Scientists performed an integrative transcriptomic analysis, comparing gene expression networks across all three groups of participants and finding unique molecular profiles and pathway enrichment patterns.

The transmission of different states of gene expression through multiple cell divisions and across generations has been termed «epigenetic,» since the underlying DNA sequence is identical in both states.

Correlation of gene expression occurred across lean and obese mice, defining a common transcriptional response to variations in adiposity.

The most significant changes occurred in a gene called RbAp48, whose expression declined steadily with aging across the study subjects.

To work out the genetic basis, Duke University postdoctoral associate Bob Fitak and biology professor Sönke Johnsen and colleagues investigated changes in gene expression that take place across the rainbow trout genome when the animal's magnetic sense is disrupted.

(Mixture - of - Isoforms) for isoform quantitation using RNA - Seq is a probabilistic framework that quantitates the expression level of alternatively spliced genes from RNA - Seq data, and identifies differentially regulated isoforms or exons across samples.

Most of these were invalidated when challenged with experimental data generated in Smith's laboratory, which measured gene expression of ESCs across 23 different cell culture conditions, all of which maintained pluripotency.

The ability of Nanopore sequencing to define the complete exonic structure of CACNA1C allows us to identify known and novel gene isoforms, including novel exons and multi-exonic skipping events and their expression across multiple brain regions.

・ Discovery that the defense mechanism against exogenous gene expression, and DNA degradation activity, differ across cell lines.

Now researchers at UC San Francisco have taken the first step toward a comprehensive atlas of gene expression in cells across the developing human brain, making available new insights into how specific cells and gene networks contribute to building this most complex of organs, and serving as a resource for researchers around the world to study the interplay between these genetic programs and neurodevelopmental disorders such as autism, intellectual disability and schizophrenia.

The evidence of ortholog genes expression which likely associated with Smad proteins, Wnt, TGF - β signaling pathways, and cartilage formation in S. pistillata supports previous reports suggesting that gene regulatory pathways of development and biomineralization processes across the metazoan evolution are considerably conserved (Jackson et al., 2007; Marin et al., 2008).

Gene - level expression values were represented by fragments per kilobase exon per million reads mapped (FPKM) and a consensus FPKM was determined for each gene based on its representation across biological replicaGene - level expression values were represented by fragments per kilobase exon per million reads mapped (FPKM) and a consensus FPKM was determined for each gene based on its representation across biological replicagene based on its representation across biological replicates.

The method, PrediXcan, estimates gene expression levels across the whole genome — a better measure of biological action than single mutations — and integrates it with genome - wide association study (GWAS) data.

On Supplementary Fig. 36c, we show the number of most informative genes (defined as the union of genes with importance > = 0.1 across all the 13 models in the case of the gene expression model, and the union of the genes with importance > = 0.1 across the 3 models in the case of TIN, with «importance» being a measure computed by xgboost) with respect to each tissue and data type.

The bags» locations in the genome are similar across cell types, although the bags» contents and roles can change from transcription factors (blue OSN oval) and enhancers (red box) that promote the gene (green) expression (left diagram) or to repressors (right diagram) that inhbit gene expression (gray box).

a Distribution of Pearson correlation between gene expression and PMI, across the different tissues (sorted by sample size, in parenthesis).

IMPRINTOME STOP SIGNS: Gene expression patterns for 42 imprinted genes (y axis) vary across diverse tissues (x axis), with redder boxes denoting stronger skewing towards just one allele.

We work across disciplines and use a variety of techniques including microfluidics, standard microscopies (electron, optical, fluorescence, confocal), spectroscopies (fluorescence, UV, CD), scattering techniques (X-ray, light), protein expression and characterization and cell - free gene expression to investigate the utility of coacervate microdroplets as robust reaction compartments and cellular mimics.

Further discussion on detectable and tissue specificity expression and gene expression patterns across tissues can be found here25.

The extensive data sets of allele - specific expression across multiple tissues have allowed us to identify imprinted genes and characterize their properties.

The researchers thus went on to study the expression of Wnt genes during regeneration, and found that different members of the gene family were active at different locations across the planarian's head - to - tail axis.

RNA - seq technology offers a rapid and scalable approach to characterize how gene expression changes in response to experimental manipulations, and is applicable across a wide range of taxa.

They focused their search on expression levels of two sets of genes, those that remained largely unchanged across all four species, suggesting that there was little room — or need — for improvement, and those that changed most dramatically, usually in the human lineage — an indication of powerful incentives to adapt to a changing environment.

Points with a mean counts below the dashed line were filtered prior to multiple test correction, as genes with low mean counts across conditions have little or no power to detect differential expression (see methods for more details).

The gene - of - interest is first inspected on three aspects in the BXD GRP, i.e. the existence of genetic variations, e (p) QTLs, and its expression pattern across strains.

To compare the expression values across genes and conditions, raw count data was transformed into fragments per kilobase of exon per million fragments (FPKM) with the formula: