Sentences with phrase «gene expression by»

More recent research on the epigenetic modification of gene expression by early maternal care in animals suggests the possibility of similar processes affecting human development.

Controls gene expression by turning on some genes while turning off the expression of other genes.

Second, we analyzed Nodal target gene expression by RNA - Seq at four time points prior to or during early gastrulation in wild - type and toddler mutants.

Transcriptional Suppression of Matrix Metalloproteinase - 9 Gene Expression by IFN --LCB- gamma -RCB- and IFN --LCB- beta -RCB-: Critical Role of STAT - 1 -LCB- alpha -RCB-

LncRNAs have been shown to regulate gene expression by modifying chromatin, enhancing transcription, and promoting messenger RNA (mRNA) degradation as well as through other methods that have yet to be elucidated.

Here, we have shown for the first time that the unphosphorylated STAT2 could play an important role in RIG - G gene expression by interacting with IRF - 9, further reinforcing the idea that STAT proteins could function as transcription factors in the absence of tyrosine phosphorylation.

[53] We have also demonstrated similar effects of GHRH antagonists on in vivo cytokine gene expression by HCC1806 and MX - 1 triple negative human breast cancer.

Similarly, HPP - 4382 was able to overcome repression of ARE - dependent gene expression by wild - type Bach1 protein but not mutant Bach1 protein.

A short stretch of DNA that regulates gene expression by acting as a landing platform for regulatory proteins, e.g. transcription factors.

Bach1 regulates ARE gene expression by binding to the small Maf proteins and ARE sequences that are also separately bound by Nrf2 [16]--[18].

This methodology provides insight into the issue of mechano - sensitive gene expression by revealing the correlation of in vivo tissue deformation patterns with Twist protein expression in stomodeal cells at gastrulation.

That these CP motifs are also required for the ability of HPP - 4382 to derepress Bach1 indicates a requirement for this metalloporphyrin binding site in Bach1 for induction of HMOX gene expression by HPP - 4382.

We confirmed the role of Nrf2 in the regulation of HMOX1 gene expression by HPP - 4382 using genetic silencing of Nrf2.

Silencing of total mTOR gene expression by siRNA decreased AKT phosphorylation.

Inversely, almost complete inhibition of AKT1 gene expression by AKT1 - specific siRNA resulted in decreased p - mTOR levels (Fig. 3C).

These robust regulators of genetic programs comprise a novel class of small, noncoding RNAs that regulate gene expression by repressing protein translation.

Intracellular uptake and inhibition of gene expression by PNAs and PNA - peptide conjugates.

The initial work was mainly focused on the study of the regulation of muscle chromatin and gene expression by motor innervation.

His lab is interested in the regulation of gene expression by mRNA processing in C. elegans and human cells.

ATRA regulates gene expression by activating the retinoic acid receptor.

The researchers then developed a new type of single - strand RNA interference (RNAi) agent, the proline - modified short hairpin RNA (PshRNA), which suppresses gene expression by utilizing the cellular system.

These data suggest that PAD4 mediates gene expression by regulating Arg methylation and citrullination in histones.

Scientists at Sylvester Comprehensive Cancer Center at the University of Miami Miller School of Medicine have shown that p300, a protein that increases gene expression by attaching acetyl molecules to DNA, may stop myelodysplastic syndrome (MDS) from developing into acute myeloid leukemia (AML).

Their findings, described in and featured on the cover of the current issue of Genes and Development, reveal that many of these lncRNAs in the lung regulate gene expression by opening and closing the DNA scaffolding on neighboring genes.

It is a crucial network in the nucleus, providing mechanical support to the nucleus and also regulating gene expression by making some areas of the genome less or more available to be transcribed into messenger RNA.

With the best - performing particles, the researchers reduced gene expression by more than 50 percent, for a dose of only 0.20 milligrams per kilogram of solution — about one - hundredth of the amount required with existing endothelial RNAi delivery vehicles.

Wyrick and his colleagues also saw less damage around transcription factors, proteins that bind to specific, short stretches of DNA and regulate gene expression by controlling which genes are turned on and off.

As sensitive as alternative splicing reacts to (slightly) elevated temperature, a temperature - induced change in gene expression by fever appears to be a logical consequence.

«It is exciting to find a correlation between brain circuitry and gene expression by combining high quality data from these two large - scale projects,» says David Van Essen, Ph.D., professor at Washington University in St. Louis and a leader of the Human Connectome Project.

«This could mean that the reversal or suppression of pathological gene expression by beta blockers is somehow protective against heart failure, but it's something we would need to look into further to understand how individual genes function in the heart.»

EPFL biologists and geneticists have uncovered how the circadian clock orchestrates the 24 - hour cycle of gene expression by regulating the structure of chromatin, the tightly wound DNA - protein complex of the cell.

Not exact matches

Secretory antibodies in breast milk promote long - term intestinal homeostasis by regulating the gut microbiota and host gene expression

Taylor and colleagues made this discovery by exposing fetal mice to BPA during pregnancy and examining gene expression and DNA in the uteruses of female fetuses.

Results showed that BPA exposure permanently affected the uterus by decreasing regulation of gene expression.

The resulting transcriptional profiles cluster not by postpartum day, but by milk Na: K ratio, indicating that women sampled during similar postpartum time frames could be at markedly different stages of gene expression.

The vaccine can be targeted to the chosen pathogen by using RNA molecules which share sequence identity with the pest's genes and prevents their expression.

The shared patterns of gene expression in the limbs and phallus are generated in part by a common set of noncoding DNA, also called «elements» or «enhancers,» which act to control gene expression in both of these structures, argues a study published October 1 in Developmental Cell.

Scientists at Southern Methodist University, led by Professor and Chair of Biological Sciences Santosh D'Mello, have used RNA - Seq to conduct transcriptome profiling of gene expression changes in dying neurons.

In the new research, the UB scientists found they could reverse those social deficits with a very low dose of romidepsin, which, they found, restores gene expression and function using an epigenetic mechanism, where gene changes are caused by influences other than DNA sequences.

An international team led by researchers with the Lawrence Berkeley National Laboratory (Berkeley Lab) has developed a new technique for identifying gene enhancers — sequences of DNA that act to amplify the expression of a specific gene — in the genomes of humans and other mammals.

«Autism's social deficits are reversed by an anti-cancer drug: Using an epigenetic mechanism, romidepsin restored gene expression and alleviated social deficits in animal models of autism.»

A protein called peroxisome proliferator — activated receptor g co-activator 1 - alpha (PGC1 - alpha) regulates the expression of many genes identified by the researchers.

Volatile release stimulated by volicitin may also depend on the octadecanoid pathway, raising the possibility of cross talk between this molecule and the wound - induced expression of defense genes.

A team of researchers from BWH has tackled this problem by comprehensively analyzing gene expression and protein distribution in human aortic valves obtained from valve replacement surgery.

Messenger RNA (mRNA) serves as an important intermediary during gene expression, by relating the genetic information of DNA to the molecular mechanisms involved in manufacturing proteins.

A single miRNA can ramp down expression of multiple genes — but the number of genes affected by known miRNAs hasn't been determined.

This image shows the metabolic expression of a gene identified by scientists from EPFL in Lausanne and ETH Zürich as being a key player in the development of type 2 diabetes.

By identifying gene expression signatures common to sight, touch and hearing, neuroscientists at the University of Geneva (UNIGE), Switzerland, discovered a sensory «lingua franca» which facilitates the brain's interpretation and integration of sensory input.

A team of scientists led by the University of Birmingham has shown how a common mRNA modification, N6 - methyladenosine (m6A), regulates gene expression to determine the sex of fruit flies.

The overlap in gene expression changes when neural progenitor cells are infected by African or Asian strains of Zika virus.