Specific projects include the use of gene expression signatures to predict recurrent rectal cancer, the study
of gene expression changes in response to chemotherapy and radiation, differential gene expression between primary tumor and metastatic deposits, and analysis of expression patterns to provide more accurate cancer staging.
As the principle
significant gene expression changes observed in the V+S + fraction are related to adhesion and migration (Table S2), this might explain the decreased capacity of these cells to incorporate into a host ICM and instead colonize the extra-embryonic endoderm.
Seeking a more viable path forward, Annika Axelsson and colleagues used a computational approach to identify compounds that might counter the disease - associated
gene expression changes associated with type 2 diabetes.
This same feature, tumor heterogeneity, may reduce the ability to identify critical
gene expression changes when comparing mean gene expression in adjacent tumor and normal tissues, as tumors of the same type may have different sets of genes differentially expressed.
In brief, the studies consisted of seven analyses on gene regulation in undifferentiated ES cells, focusing on LIF targets, Stat3 and PI3K regulated genes, as well as
global gene expression changes through epigenetic mechanisms; and, four studies where ES cells were allowed to differentiate in monolayers or as embryoid bodies.
However, while the genetic factors responsible for reprogramming are well known, the mechanisms underlying the responses to
induced gene expression changes are not as clear.
We are also examining how
gene expression changes caused by chromatin modifier mutations interact with other commonly mutated pathways in urothelial cancers such as RTK - RAS - RAF and PI3K - AKT - MTOR to influence therapeutic response and resistance.
«Our work suggests that fine - tuning messenger stability is an important mechanism orchestrating
gene expression changes during normal brain development.»
By intersecting genes which are differentially expressed between current and never smokers with those that are different between former and never smokers, we can identify irreversible
gene expression changes upon smoking cessation.
According to the researchers, this is the first study to link the extreme and rapid eating - induced changes of the Burmese python's intestines directly to changes in gene expression, and also the first to show how
quickly gene expression changed.
The researchers demonstrated that blocking the PGD enzyme genetically or with a pharmacologic inhibitor reversed the epigenetic reprogramming and
malignant gene expression changes detected in distant metastases, and also strongly inhibited their tumor - forming capacity, with no effect on normal cells or peritoneal pancreatic cancer controls.
They identified 60 genes that exhibited convergent evolution in CAM species, including convergent daytime and
nighttime gene expression changes in 54 genes, as well as protein sequence convergence in six genes.
While nicotine and non-nicotine products both produced changes, e-cigarette products without nicotine resulted in even
more gene expression changes than products with nicotine, Zelikoff said.
This is important, he added, because this technique is increasingly used for classifying diseases and their subtypes,
understanding gene expression changes during development and tracking the progression of cancer.
Their findings revealed a dramatic and diverse landscape of
gene expression changes across all cell types, involving 611 different genes, many linked to neural connectivity and the brain's ability to rewire itself to learn and adapt.
This work will initiate new awareness of
circadian gene expression changes in aging and dietary restriction studies and contribute to the sub-discipline of «chronogerontology».
Nick Owens, a post doc in Mike Gilchrist's lab, who developed the computational analysis, said: «This study improves our ability to understand the
way gene expression changes with time, and from this we gain insight into the logic of how gene expression is regulated.
Dr. Stacie Loftus is a member of the Genomics, Development and Disease Section and investigates how
gene expression changes affect the function and survival of melanocyte cells.
Research funded by the Life Extension Foundation showed that a combination of low - dose (20 mg) resveratrol plus grapeseed extract mimicked many of the
favorable gene expression changes seen in calorie - restricted animals.
Using an experimental model of heart failure and next generation sequencing to get a snapshot of all of the RNA in the heart cells, the researchers identified the
global gene expression changes that occur in heart failure.
Qu S, Olafsrud SM, Meza - Zepeda LA, Saatcioglu F (2013)
Rapid Gene Expression Changes in Peripheral Blood Lymphocytes upon Practice of a Comprehensive Yoga Program.
«We identified a COPD - specific signature by
comparing gene expression changes in COPD - derived chips exposed or not exposed to smoke and subtracting the changes that we see in chips made from healthy lung chips,» says first author, Kambez H. Benam.
RNA - seq technology offers a rapid and scalable approach to characterize
how gene expression changes in response to experimental manipulations, and is applicable across a wide range of taxa.
Scientists at Southern Methodist University, led by Professor and Chair of Biological Sciences Santosh D'Mello, have used RNA - Seq to conduct transcriptome profiling
of gene expression changes in dying neurons.
Fascinating research from the lab of Mark Zylka, PhD, director of the UNC Neuroscience Center, suggests that chemicals designed to protect crops can cause
gene expression changes in mouse brain cells.
Any risk to agriculture is likely to prevent wide scale use of biochar and we now need to see which pest and pathogens are sensitive to
the gene expression changes..»