Sentences with phrase «gene expression changes resulting»

This approach allowed the researchers to accurately detect gene expression changes resulting from the reactions.

Not exact matches

While nicotine and non-nicotine products both produced changes, e-cigarette products without nicotine resulted in even more gene expression changes than products with nicotine, Zelikoff said.

When his team looked at gene expression changes in the mice, then applied them to humans with early stage cancer, the results revealed a breakdown of which patients have a high or low chance of survival.

The mGlu2 decrease, they determined, resulted from an epigenetic change, which affects the expression of genes, in this case the gene that codes for mGlu2.

Gene moonlighting can occur merely through changes in expression, which may result from as little as a single mutation; it does not require the meandering process of random alteration and selection implied by the duplication and neofunctionalization model.

The results showed a correlation between changes in his brain and alterations in the expression of many families of genes in his blood.

Decades of research have shown that differentiation is the result of stereotypic gene expression changes that are required to specify the fate of a cell.

This is consistent with our finding that the post-mortem transcriptomic changes are both the result of RNA degradation and of regulated gene expression.

Changes in gene expression as a response to death, and during subsequent post-mortem ischemia, might be expected to reflect stochastic variation resulting from the enzymatic processes underlying mRNA degradation.

The approach to target validation utilizes RNAi, CRISPR, and ORF expression platforms to genetically perturb candidate target gene expression in relevant cancer cell lines, and then profile the resulting phenotypic changes with regard to their effect on various biochemical pathways.

So what kind of harm can the changes in gene expression resulting from (epi) mutations cause?

Melanocytes respond by altering gene transcription, and these changes in gene expression profiles result in easily quantifiable phenotypes such as modified pigment production (a hallmark of melanocyte differentiation state) and changes in morphological cell properties.

Proteomic analysis to profile protein abundance resulted in the identification and relative quantification for 912 proteins with two or more unique peptides and 86 proteins with significant abundance changes after treatment with the neurotoxins, while microarray analyses to profile gene expression revealed 181 genes with significant changes in mRNA after treatment.

Moreover, CRISPRi did not result in any off - target changes in gene expression — a commonly cited problem with CRISPR / Cas9.

Results: Here, we profile genome - wide changes in DNA methylation, gene expression and lipidomics in response to DR and aging in female mouse liver.

Results: Within 4 h, activation of CD4 (+) T cells invokes changes in histone modifications and enhancer RNA transcription that correspond to altered expression of the interacting genes identified by promoter capture Hi - C.

«And that most probably resulted from a change in the pattern of Hox gene expression,» says Böhmer.

The theory proposed by Professor Khavinson is based on the underlying assumption that changes in gene expression result in decreased protein synthesis, eventually leading to aging and the development of diseases.

It is likely that a combination of several factors (e.g. age - related changes at the level of gene expression, infectious agents, toxic compounds, and head trauma) affects the neuronal milieu and initiates neuropathological processes leading to the formation of toxic tau and amyloid β species, reduction of synaptic plasticity, and neuronal loss resulting in development of sporadic AD.»

Finally, because we did not measure gene expression, the current results await replication and extension using methods that can clarify whether the observed effects are associated with changes in gene expression that would indicate up or down regulation of TNF.