Sentences with phrase «gene expression patterns for»

IMPRINTOME STOP SIGNS: Gene expression patterns for 42 imprinted genes (y axis) vary across diverse tissues (x axis), with redder boxes denoting stronger skewing towards just one allele.

«Gene analysis adds layers to understanding how our livers function: Tracking gene expression patterns for 20,000 gene in 1,500 cells revealed a mosaic of activities.»

This work shows the power of using the tools of computational genomics to analyze gene expression patterns for the purpose of elucidating the evolution of behavior.

Not exact matches

They used a computer to trawl through 2,100 of the samples and look for patterns of gene expression.

The trick is to run the tape of evolution over again: to intervene in the development of a chicken embryo, for instance, to reverse evolution, rolling back the clock to manifest earlier patterns of gene expression.

«We used the Allen Human Brain Atlas data to quantify how consistent the patterns of expression for various genes are across human brains, and to determine the importance of the most consistent and reproducible genes for brain function.»

Although a bad outcome was possible without the gene expression pattern, patients with the genetic signature were found to survive for less time than those who didn't have it, they wrote in the 9 December online edition of Nature Genetics.

Then they explored what happened to this pattern of gene expression when beta blocker treatment was implemented, and what they found not only surprised them, but could have important ramifications for future treatments of heart disease.

Researchers have videotaped cultures in which embryos develop but found no visual pattern that hints at which cells are about to sprout, and staining for certain patterns of gene expression has been inconclusive.

For Helicobacter pylori, a pathogenic bacterium that colonizes over 40 percent of the world population and is associated with gastric cancer, the team discovered that epigenetic heterogeneity can quickly emerge as a single cell divides, and different subpopulations with distinct methylation patterns have distinct gene expressions patterns.

In collaboration with Prof. Ido Amit of Weizmann's Immunology Department, they analyzed the genomes of 1,500 individual liver cells, establishing patterns of expression for about 20,000 genes in each cell.

MEGENA (for Multiscale Embedded Gene Co-expression Network Analysis) projects gene expression data onto a three dimensional sphere, allowing scientists to study hierarchical organization patterns in complex networks that are characteristic of diseases such as cancer, obesity, and AlzheimeGene Co-expression Network Analysis) projects gene expression data onto a three dimensional sphere, allowing scientists to study hierarchical organization patterns in complex networks that are characteristic of diseases such as cancer, obesity, and Alzheimegene expression data onto a three dimensional sphere, allowing scientists to study hierarchical organization patterns in complex networks that are characteristic of diseases such as cancer, obesity, and Alzheimer's.

Rather than listing specific genes that manifest themselves differently, or are differentially expressed, between queens and workers, the team looked for genes with similar expression patterns across samples that may be involved in maintaining the structural, behavioural and functional differences observed between queens and workers.

«We're showing for the first time that Müller glia in the adult mouse can give rise to new neurons after injury, and these neurons have the gene expression pattern, the morphology, the electrophysiology, and the epigenetic program to look like interneurons instead of glia,» Reh said.

The pattern of gene expression is strikingly similar to that for individual olfactory receptor genes, Liberles says.

Now, researchers at the Institute for Comprehensive Medical Science, Fujita Health University, and ATR Computational Neuroscience Laboratories in Japan have succeeded in predicting states of mood - change - like behavior by studying the gene expression patterns in the brain in a bipolar disorder mouse model.

I found that negative selection against new mutations and positive selection for new mutations shape broad patterns of genomic variation and that much of the genomic variation that actually affects gene expression is under negative selection.

Gene expression patterns in normal adult or the developing retina have been reported for mouse [18 — 23], aged and normal adult human [24 — 26], canine [27], and rabbit [28].

Many leukemias exhibit mixed - lineage patterns of gene expression, for example of both macrophage and lymphocyte genes.

The NIH Roadmap Epigenomics Consortium has just published the largest collection of epigenomes characterized to date: 111 primary human tissues and cells profiled for histone modification patterns, DNA accessibility, DNA methylation, and gene expression.

One of my favorite papers from this year was the landmark publication of the NIH Epigenomics Roadmap Consortium, which profiled 111 primary human tissues and cell types for histone modification patterns, DNA accessibility, DNA methylation, and gene expression.

The same can be said for patterns of gene expression changes in the same brain region for different age frames.

Using genechip technology, a powerful tool for analyzing the expression patterns of thousands of genes at a time, researchers have identified a number of genes that are specifically regulated by the...

This resource will be valuable for researchers studying gene expression patterns in coral reproductive cycles and evolution of the genus Acropora.

ARNIE is an online database that integrates the extracellular protein interaction network generated in our lab using AVEXIS technology with spatiotemporal expression patterns for all genes in the network.

Deeper analyses, revealed that the RNA expression pattern of a rare variant of the NCAN gene was highly correlated with that of the previously suggested susceptibility genes for developmental dyslexia.

«The authors went on to study the resulting blastocysts for aneuploidy (frequency of abnormal chromosomes), and pattern of gene expression (which genes are active and at what level).

In multicellular organisms, functional duplicate copies of a gene can exist in a genome, but if their expression patterns do not overlap, their products are unable to compensate for each other if either gene is mutated.

Specifically, use of post-mortem material is crucial for studying the patterns of normal gene expression underlying tissue specificity within individuals, as sampling such tissues from living individuals would be impossible.

Each subtype was classified by gene expression clustering, and showed specific patterns of genetic alterations, particularly for four genes: platelet - derived growth factor receptor alpha (PDGFRA), isocitrate dehydrogenase 1 (IDH1), epidermal growfth factor receptor (EGFR), and neurofibromin 1 (NF1).

A reliability score is set manually for all genes and indicates the level of reliability of the analyzed protein expression pattern based on available protein / RNA / gene characterization data from both HPA and the UniProtKB / Swiss - Prot database.

Using novel gene - array technology to measure the extent of gene expression in thousands of genes simultaneously, this study shows that as humans diverged from their ape ancestors in the last five million years, genes for transcription factors — which control the expression of other genes — were four times as likely to have changed their own expression patterns as the genes they regulate.

Click «Expression Details» to view all expression annotations and details for this locus, including a visualization of genes that share a similar expressioExpression Details» to view all expression annotations and details for this locus, including a visualization of genes that share a similar expressioexpression annotations and details for this locus, including a visualization of genes that share a similar expressionexpression pattern.

Identifying gene expression patterns in relation to the compound could facilitate the selection of the most appropriate patient cohorts for clinical development.

A reliability score is set for all genes and indicates the level of reliability of the analyzed protein expression pattern based on available protein / RNA / gene characterization data.

«It's been a puzzle that lots of leukemias exhibit mixed lineage patterns of gene expression - for example of both macrophage and lymphocyte genes,» he said.

The only clue indicating that differences in gene expression level are not the reason for the observed correlation between the recombination rate and the size of introns is that we do not see a comparable pattern when examining the size of exons, the number of exons per gene, and the overall size of proteins.

It has been demonstrated that the composition of the medium used for embryo culture has a profound effect on the methylation pattern in the resultant two - cell embryos [10], indicating that, in addition to imprinted genes, other epigenetic alterations may intensely modify gene expression.

Now researchers at the Salk Institute for Biological Studies have identified an essential cellular pathway in zebrafish that paves the way for limb regeneration by unlocking gene expression patterns last seen during embryonic development.

After clicking on any of the panels, for example on the top left panel marked with a red asterisk, the expression profiles of the individual genes that follow the corresponding pattern as well as their names appear in a new window (as shown in B).

Besides information gathered to answer specific experimental questions, as determined by the interests of individual partners [35]--[41], the collective data offered the opportunity to search for coordinated gene expression patterns in a systematic exploration of the mouse ES transcriptome under a battery of different experimental settings, thus minimizing possible site - specific artifacts.

The FunGenES database provides such a template with a number of tools including Animation of KEGG Pathways, Expression Waves, Time Series, Specific Gene Classes, such as ESTs and transcription factors, and searches for the expression pattern of any gene or transcript during ES cell differentiation using standard gene nameExpression Waves, Time Series, Specific Gene Classes, such as ESTs and transcription factors, and searches for the expression pattern of any gene or transcript during ES cell differentiation using standard gene names and Gene Classes, such as ESTs and transcription factors, and searches for the expression pattern of any gene or transcript during ES cell differentiation using standard gene nameexpression pattern of any gene or transcript during ES cell differentiation using standard gene names and gene or transcript during ES cell differentiation using standard gene names and gene names and IDs.

Specifically, we have generated clusters of transcripts that behave the same way under the entire spectrum of the sixty - seven experimental conditions; we have assembled genes in groups according to their time of expression during successive days of ES cell differentiation; we have included expression profiles of specific gene classes such as transcription regulatory factors and Expressed Sequence Tags; transcripts have been arranged in «Expression Waves» and juxtaposed to genes with opposite or complementary expression patterns; we have designed search engines to display the expression profile of any transcript during ES cell differentiation; gene expression data have been organized in animated graphs of KEGG signaling and metabolic pathways; and finally, we have incorporated advanced functional annotations for individual genes or gene clusters of interest and links to microarray and genomic expression during successive days of ES cell differentiation; we have included expression profiles of specific gene classes such as transcription regulatory factors and Expressed Sequence Tags; transcripts have been arranged in «Expression Waves» and juxtaposed to genes with opposite or complementary expression patterns; we have designed search engines to display the expression profile of any transcript during ES cell differentiation; gene expression data have been organized in animated graphs of KEGG signaling and metabolic pathways; and finally, we have incorporated advanced functional annotations for individual genes or gene clusters of interest and links to microarray and genomic expression profiles of specific gene classes such as transcription regulatory factors and Expressed Sequence Tags; transcripts have been arranged in «Expression Waves» and juxtaposed to genes with opposite or complementary expression patterns; we have designed search engines to display the expression profile of any transcript during ES cell differentiation; gene expression data have been organized in animated graphs of KEGG signaling and metabolic pathways; and finally, we have incorporated advanced functional annotations for individual genes or gene clusters of interest and links to microarray and genomic Expression Waves» and juxtaposed to genes with opposite or complementary expression patterns; we have designed search engines to display the expression profile of any transcript during ES cell differentiation; gene expression data have been organized in animated graphs of KEGG signaling and metabolic pathways; and finally, we have incorporated advanced functional annotations for individual genes or gene clusters of interest and links to microarray and genomic expression patterns; we have designed search engines to display the expression profile of any transcript during ES cell differentiation; gene expression data have been organized in animated graphs of KEGG signaling and metabolic pathways; and finally, we have incorporated advanced functional annotations for individual genes or gene clusters of interest and links to microarray and genomic expression profile of any transcript during ES cell differentiation; gene expression data have been organized in animated graphs of KEGG signaling and metabolic pathways; and finally, we have incorporated advanced functional annotations for individual genes or gene clusters of interest and links to microarray and genomic expression data have been organized in animated graphs of KEGG signaling and metabolic pathways; and finally, we have incorporated advanced functional annotations for individual genes or gene clusters of interest and links to microarray and genomic resources.

CT values for cyclophilin were somewhat more variable in cells isolated by flow cytometry and frozen prior to analysis, compared to freshly isolated and unmanipulated cells, but the gradients in patterns of gene expression were similar for cells isolated by the two techniques (Figure 3a — d).

More recently, it has been suggested that the contrasting attributes of gene compactness, GC content and the length of the intronic and intergenic sequences in Hkg and Tsg might be involved in chromatin mediated regulation for maintaining distinct expression patterns in the gene sets [29].

A direct positive feedback loop, in which the intracellular domain of activated Notch receptors binds to an enhancer in the second intron of the Notch1 gene to enhance its expression, is critical for intestinal stem cell self ‐ renewal and niche patterning.

Moreover, they have shown that, through differential patterns of DNA methylation of the promoter region and thereby differential expression of the estrogen receptor alpha gene in the medial preoptic area (MPOA) of the brain, this individual variation of early experience influences adult reproductive behaviour, suggesting a mechanism for intergenerational transmission of the pattern of maternal care [137, 138].